Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men

Shimizu, Yūji; Yoshimine, Hiroyuki; Nagayoshi, Mako; Kadota, Koichiro; Takahashi, Kensuke; Izumino, Kiyohiro; Inoue, Kenichiro; Maeda, Takahiro

doi:10.1007/s12199-016-0532-4

Cited by 8 publications

(12 citation statements)

References 20 publications

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“…Shumizu et al recruited 1528 Japanese male subjects, including 241 patients with OSA. They found that OSA was associated with elevated AIP but only in normal-weight subjects (BMI < 25 kg/m 2 ) [ 18 ]. Wu et al investigated 246 male bus drivers from Taiwan.…”

Section: Discussionmentioning

confidence: 99%

“…Lower TC levels in the OSA group were, therefore, likely due to an increased usage of statins in these patients. In the previous studies, patients on statins were either included [ 19 , 22 ], excluded [ 21 ], or the results were adjusted for statin usage [ 18 , 23 ]. Nevertheless, excluding patients on statins did not change our conclusions on AIP.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies suggested that obesity could be a significant covariate determining the relationship between AIP and OSA [ 18 , 19 ]. However, a large European study found that the relationship between OSA and TGs, as well as HDL-C, was independent of obesity [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Only six studies have investigated TG/HDL-C ratio or AIP in OSA [ 18 , 19 , 20 , 21 , 22 , 23 ], but only four of them compared patients with OSA to non-OSA controls [ 14 , 15 , 21 , 23 ]. Three of these studies were conducted in Eastern Asia [ 14 , 15 , 21 ] and one in Brazil [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Bikov

Mészáros

Kunos

et al. 2021

JCM

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Background: Dyslipidaemia is well recognised in obstructive sleep apnoea (OSA) and could contribute to the development of cardiovascular disease (CVD). Atherogenic index of plasma (AIP) predicts cardiovascular morbidity and mortality better than the individual lipid levels. The aim of this study was to investigate the AIP in patients with OSA in relation with disease severity. Methods: Four hundred sixty-one patients with OSA and 99 controls participated in this study. AIP was assessed in the morning following a diagnostic sleep study. The association between lipid values and OSA were adjusted for age, gender, and body mass index. Results: Patients with OSA had higher AIP and triglyceride, and lower high-density lipoprotein cholesterol (HDL-C) levels (all p < 0.05). AIP significantly correlated with the Epworth Sleepiness Scale score (ρ = 0.19), the apnoea-hypopnoea index (ρ = 0.40) and oxygen desaturation index (ρ = 0.43, all p < 0.05). However, there was no relationship between the AIP and markers of sleep quality such as total sleep time, sleep period time, sleep efficiency, arousal index or percentage of REM sleep (all p > 0.05). AIP was not a better predictor for self-reported cardiovascular disease or diabetes than HDL-C. Conclusions: AIP is elevated in OSA and is related to disease severity. However, it does not seem to have an additional clinical value compared to HDL-C.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Bikov

Mészáros

Kunos

et al. 2021

JCM

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“…11 To address this, the logarithmic ratio of high-density lipoprotein cholesterol (HDL-C) and triglycerides, the so called Atherogenic Index of Plasma (AIP) has been investigated in OSA before in several studies. [12][13][14][15] In addition, visceral fat distribution was demonstrated to be a better predictor for cardiovascular disease than the body mass index (BMI). 16 In line with this, composite indices which take into account both, lipid parameters and waist circumference, were better predictors for cardiovascular disease than single lipid components.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Bikov¹,

Frent²,

Reisz³

et al. 2022

NSS

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Obstructive sleep apnoea (OSA) is a recognised risk factor for cardiovascular disease. However, it is difficult to evaluate the risk of cardiovascular disease in patients with OSA due to multiple shared risk factors. Composite lipid indices, such as atherogenic index of plasma (AIP), visceral adiposity index (VAI) and lipid accumulation product (LAP) have been shown to predict cardiovascular disease better than their individual lipid components. This study aimed to evaluate these indices in patients with OSA. Patients and Methods: Six hundred sixty-seven (667) patients with OSA and 139 non-OSA control volunteers participated in the study. Fasting serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C) levels were measured, and AIP, LAP and VAI were calculated following cardiorespiratory polygraphy. The relationship between lipid parameters, OSA and its comorbidities was evaluated using receiver operating curve (ROC) analysis. Results: We found a significant difference in all lipid parameters between OSA patients and controls. Comparing ROCs, LAP was significantly more strongly associated with OSA compared to all the other parameters. The optimal cut-off value for LAP to detect OSA was 76.4, with a sensitivity of 63% and a specificity of 76%. In addition, LAP was the best parameter to predict hypertension and diabetes in patients with OSA, and it was predictive for ischaemic heart disease together with HDL-C. Conclusion: Our results support the use of LAP in clinical practice when evaluating cardiovascular risk in patients with OSA. However, the optimal cut-off value should be determined in large-scale follow-up studies.

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Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: A retrospective study

Fang

Zhao

et al. 2022

Clinical Laboratory Analysis

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BackgroundDue to the significant role of dyslipidemia, cardiovascular diseases (CVDs) are very common in obstructive sleep apnea (OSA). Nontraditional lipid indices are considered to be a better predictive index for cardiovascular risk. Nevertheless, the association between nontraditional lipid profiles and the severity of OSA is not clear.MethodsA retrospective study was proceeded on 635 patients. Subjects were diagnosed with OSA through polysomnography (PSG). The association between severe OSA and nontraditional lipid profiles [triglyceride (TG)/high‐density lipoprotein cholesterol (HDL‐C) ratio, total cholesterol (TC)/HDL‐C ratio, low‐density lipoprotein cholesterol (LDL‐C)/HDL‐C ratio, non‐high‐density lipoprotein cholesterol (non‐HDL‐C), atherogenic index (AI), and lipoprotein combine index (LCI)] was examined by utilizing the restricted cubic spline and multivariate logistic regression analysis.ResultsAll nontraditional lipid indices had positive relationships with the severity of OSA. By multivariable adjustment, the per SD increment of the TG/HDL‐C, TC/ HDL‐C, LDL‐C/HDL‐C, non‐HDL‐C, AI, and LCI were significantly associated with 88%, 50%, 42%, 40%, 50%, and 125% higher risk for severe OSA respectively. Compared with the lowest tertiles, the adjusted ORs (95% CI) were 2.42 (1.57–3.75), 2.39 (1.53–3.73), 2.35 (1.52–3.64), 1.86 (1.21–2.86), 2.39 (1.53–3.73), and 2.23 (1.43–3.48) for the top tertiles of TG/HDL‐C, TC/ HDL‐C, LDL‐C/HDL‐C, non‐HDL‐C, AI, and LCI respectively.ConclusionAll nontraditional lipid indices had positive relationship with the severity of OSA. In addition, TG/HDL‐C, TC/HDL‐C, and AI had better performance than the other nontraditional lipid indices for predicting severe OSA. These findings could help to determine the risk of cardiovascular diseases and improve the dyslipidemia management of OSA patients.

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Serum triglyceride levels in relation to high-density lipoprotein cholesterol (TG-HDL) ratios as an efficient tool to estimate the risk of sleep apnea syndrome in non-overweight Japanese men

Cited by 8 publications

References 20 publications

Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Atherogenic Index of Plasma in Obstructive Sleep Apnoea

Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea

Association between nontraditional lipid profiles and the severity of obstructive sleep apnea: A retrospective study

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