Serum type-2 macro-creatine kinase isoenzyme is not a useful marker of severe liver diseases or neoplasia

Increased activity of serum mitochondrial isoenzyme of creatine kinase in hepatocellular carcinoma patients predominantly with recurrence

“…Previous investigations reported that an increase in serum MtCK level was detectable only in cases with advanced HCC [16] and that the sensitivity of serum MtCK level for the diagnosis of HCC was relatively low [18]. In contrast, a relatively higher sensitivity of serum MtCK activity for the detection of a single HCC 62 cm was observed in the current study.…”

“…As described earlier, MtCK once attracted attention as a potential tumor-associated marker in the serum including HCC [15], however, the serum MtCK level was not judged to be a useful marker of HCC [18]. Previous investigations reported that an increase in serum MtCK level was detectable only in cases with advanced HCC [16] and that the sensitivity of serum MtCK level for the diagnosis of HCC was relatively low [18].…”

“…These findings suggest that MtCK activity may be useful as a serum marker for HCC. However, Castaldo et al reported that serum MtCK activity was detected in only 16% of HCC patients [18].…”

“…In these previous studies, serum MtCK level was measured using electrophoresis and densitometry [16,18]. On the other hand, a novel method for directly determining the enzymatic activity of MtCK has been recently established [19], and this method may have a better sensitivity and accuracy for the measurement of MtCK activity than the previous method.…”

Differentialdiagnose Makro-CK Typ 1 bei thorakalen Schmerzen und erh�hter CK-MB

“…In diesen Fällen mit Verdacht auf Makro-CK ist eine Differenzierung dieser Non-CK-M-Aktivität durch die elektrophoretische Trennung der CKIsoenzyme anzustreben. Die Makro-CK Typ 2 kann bei malignen Tumoren, Leberzirrhose oder auch beim LyellSyndrom auftreten [2,10].…”