Serum Urate Levels Predict Joint Space Narrowing in Non‐Gout Patients With Medial Knee Osteoarthritis

Krasnokutsky, Svetlana; Oshinsky, B A Charles; Attur, Mukundan; Ma, Sisi; Zhou, Hua; Zheng, Fangfei; Chen, Meng; Patel, Bipin; Samuels, Jonathan; Pike, Chris; Regatte, Ravinder R.; Bencardino, Jenny T.; Rybak, Leon; Abramson, Steven B.; Pillinger, Michael H.

doi:10.1002/art.40069

Cited by 50 publications

(41 citation statements)

References 48 publications

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“…Denoble reported in her series a 6.0-mg/dL of Uric Acid level (17), while Wangkaew referred a 6.2-mg/mL level (39). Krasnokutsky reported a serum uric acid level of 6.3 mg/dL in 88 OA patients (40). Srivastava published on patients with knee OA a 5.2-mg/dL of uric acid level, which is very similar to the current study (41).…”

Section: Discussionsupporting

confidence: 88%

Intra Articular Ozone Reduces Serum Uric Acid and Improves Pain, Function and Quality of Life in Knee Osteoarthritis Patients: A Before-and-After Study

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2018

Middle East J Rehabil Health Stud

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Objectives: The objective of this study was to evaluate if ozone is capable of improving pain, function and quality of life, and to decrease serum uric acid in human knee osteoarthritis (OA) patients. Methods: Overall, 42 patients, 31 females (73.81%) and 11 males (26.19%) were enrolled in a prospective quasi experimental before-andafter study. Mean age of the sample was 66.9 ± 8.83 years. Treatment consisted of four sessions (one per week) of an intra articular infiltration of a medical mixture of oxygen-ozone (95% to 5%), 20 mL volume at a 20 µ/mL concentration, on the most symptomatic painful knee. Before and after the intervention, the researchers measured outcomes including serum uric acid and pain, function, and quality of life by the visual analogue scale (VAS) and by Western Ontario and Mac Master index for OA (WOMAC). The OA patients were graded by Kellgren-Lawrence radiological scale as 2°to 4°grades. Results: Serum uric acid decreased from 5.19 ± 1.22 mg/dL to 5.03 ± 1.22 (P = 0.0439). The WOMAC pain subscale score decreased from 14.26 ± 2.61 to 5.95 ± 2.97 points (P = 0.0001), WOMAC stiffness subscale diminished from 2.72 ± 1.63 to 1.04 ± 1.04 points (P = 0.0001), and WOMAC function subscale improved from 41.78 ± 10.17 to 24.61 ± 9.86 points (P = 0.0001). Conclusions: Intra articular ozone is capable of decreasing pain and stiffness and improving function and quality of life, as well as decreasing serum uric acid in knee OA patients.

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Section: Discussionsupporting

confidence: 88%

Intra Articular Ozone Reduces Serum Uric Acid and Improves Pain, Function and Quality of Life in Knee Osteoarthritis Patients: A Before-and-After Study

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

et al. 2018

Middle East J Rehabil Health Stud

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“…The NYC cohort The New York University (NYU) cohort with varying degrees of symptomatic knee OA (n = 106) was recruited at New York University [15][16][17][18] (Fig. 1A).…”

Section: Study Design and Participantsmentioning

confidence: 99%

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

Luo

Samuels

Krasnokutsky

et al. 2020

Preprint

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Objective: Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilage repair. We hypothesize that a low cartilage repair endotype exists and that such endotypes are more likely to progress radiographically. The aim of this study was to examine the associations of level of cartilage formation with OA severity and radiographic OA progression. We used the blood-based marker PRO-C2, reflecting type II collagen formation, to assess levels of cartilage formation. Methods: The type II collagen propeptide PRO-C2 was measured in the serum/plasma of knee OA subjects from New York University (NYU, n=106) and a subcohort of the phase III oral salmon calcitonin (sCT) trial SMC021-2301 (SMC, n=147). The risk of radiographic medial joint space narrowing (JSN) over 24 months was compared between quartiles (very low, low, moderate, and high) of PRO-C2. Progression was defined as two-year JSN > 0.35 mm. Associations were adjusted for age, gender, BMI, race, baseline pain levels, and baseline joint space width.Results: In both the NYU and SMC cohorts, subjects with low PRO-C2 levels had greater JSN compared to subjects with high PRO-C2. The mean difference in JSN between subjects with very low and high levels of PRO-C2 was 0.65 mm (p = 0.002), corresponding to a 3.4 [1.4 – 8.6]-fold higher risk of progression. There was no significant effect of sCT treatment, compared to placebo, on JSN over two years before stratification based on baseline PRO-C2. However, there were proportionately fewer progressors in the sCT arm of the very low/low PRO-C2 group compared to the moderate/high group (chi-squared = 6.5, p = 0.011). Conclusions: Serum/plasma level of type II collagen formation, PRO-C2, may be an objective indicator of a low cartilage repair endotype, displaying radiographic progression and superior response to a proanabolic drug.

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“…Uric acid is a circulating waste product which can cause systemic and joint-based inflammation via inflammasome activation 30,31 . 88 individuals with medial knee OA, BMI < 33 and no gout 32 had baseline serum uric acid (sUA) and semi-flexed knee radiographs at 0 and 24 months. A subgroup also had baseline contrast-enhanced MRI knee synovial volume (SV) assessment.…”

Section: Biomarkers Of 'Cold Inflammation'mentioning

confidence: 99%

Osteoarthritis biomarkers: year in review

Watt

2018

Osteoarthritis and Cartilage

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Discovery, characterisation and qualification of various biomarkers is ongoing; several novel protein and non-protein candidate biomarkers have been reported this year. Biomarkers provide us with an opportunity to better diagnose and stratify the disease, via established panels or new discovery approaches. Improving quality of sampling and testing, and measuring large numbers of markers simultaneously in large cohorts would seem likely to identify new clinically applicable biomarkers, which are still much needed in this disease.

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Serum Urate Levels Predict Joint Space Narrowing in Non‐Gout Patients With Medial Knee Osteoarthritis

Cited by 50 publications

References 48 publications

Intra Articular Ozone Reduces Serum Uric Acid and Improves Pain, Function and Quality of Life in Knee Osteoarthritis Patients: A Before-and-After Study

Intra Articular Ozone Reduces Serum Uric Acid and Improves Pain, Function and Quality of Life in Knee Osteoarthritis Patients: A Before-and-After Study

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

Osteoarthritis biomarkers: year in review

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