Serum Uric Acid as an Independent Predictor of Early Death After Acute Stroke

Karagiannis, Asterios; Mikhailidis, Dimitri P.; Τζιόμαλος, Κωνσταντίνος; Sileli, Maria; Savvatianos, Savvas; Kakafika, Anna I.; Gossios, Thomas D.; Krikis, Napoleon; Moschou, Irene; Xochellis, Michael; Athyros, Vasilios G.

doi:10.1253/circj.71.1120

Cited by 117 publications

(86 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent study showed that in type 2 diabetic subjects elevated plasma UA levels were associated with increased arterial stiffness, which is a well-recognised cardiovascular risk factor [16]. Several studies in the general population showed an effect of serum UA levels on prediction of stroke outcomes [17][18][19]. Two studies have showed that elevated levels of UA were independently associated with an increased risk of early death after acute stroke [17,18].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in the general population showed an effect of serum UA levels on prediction of stroke outcomes [17][18][19]. Two studies have showed that elevated levels of UA were independently associated with an increased risk of early death after acute stroke [17,18]. In addition, in patients admitted with stroke, serum UA was an independent predictor of future cardiovascular events in the next 2 years [19].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

View full text Add to dashboard Cite

Abstract:Background: Diabetes mellitus is a well-established risk factor for ischemic stroke and is associated with increased in-hospital mortality. The aim of the present study was to determine the potential predictors of in-hospital mortality after an ischemic stroke in diabetic and nondiabetic subjects. Methods: 159 diabetic subjects (66 males / 93 females, mean age ± SD: 77.4 ± 6.4 years) and 159 non diabetic subjects (66 males / 93 females, mean age ± SD: 77.3 ± 5.2 years) hospitalized for ischemic stroke were studied. Demographic characteristics and laboratory tests on admission as well as outcome were recorded. Brain computed tomography scan was performed in all study subjects. Results: In-hospital death rates did not differ between the diabetic and the nondiabetic patients [36 (22.6%) vs. 27 (17.0%), respectively, P = 0.20]. In the diabetic study group multivariate analysis, after controlling for CRP, total cholesterol, LDL-C, urea and creatinine levels, demonstrated that death was related with WBC count (OR: 1.002, 95% CI: 1.001-1.004, P = 0.005), glucose levels (OR: 1.007, 95% CI: 1.002-1.012, P = 0.008), and UA levels (OR: 1.51, 95% CI: 1.003-2.260, P = 0.05). In the nondiabetic study group, after controlling for WBC count, CRP, total cholesterol and LDL-C levels, death was related only with glucose levels (OR: 1.016, 95% CI: 1.001-1.031, P = 0.03). Conclusions: WBC count and UA levels on hospital admission are independent predictors for in-hospital mortality in diabetic subjects with ischemic stroke. Plasma glucose levels are predictor for in-hospital mortality in both diabetic and nondiabetic subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

View full text Add to dashboard Cite

show abstract

“…3 Interestingly, these potentially contradictory properties have also been observed with uric acid, another end product of a major metabolic pathway. [4][5][6] The acute stroke setting may represent an opportunity to further examine the role of bilirubin in the pathophysiology of brain injury or as a neuroprotectant because early cerebral ischemia involves oxidative stress, 7 and identifying therapeutic avenues to limit the damage from stroke remains an area of extremely active investigation. 7 Nonetheless, few studies have examined any role for bilirubin in acute stroke.…”

mentioning

confidence: 99%

Association of Serum Bilirubin with Ischemic Stroke Outcomes

Pineda

Bang

Saver

et al. 2008

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

show abstract

“…22,23 Amerenco P et al conducted a meta-analysis of 90000 patients and found that administration of statins reduces the risk of stroke among patients with coronary artery disease and that this risk reduction is primarily related to the extent to which LDL-C levels are lowered. [24][25][26] In some studies relating metabolic syndrome and serum uric acid; increased serum uric acid levels correlated with low HDL-C levels. In our study mean serum uric acid level was found to be lower in patients who had elevated serum cholesterol (>200 mg/dl), triglycerides (>150 mg/dl) and LDL (>120 mg/dl) than those with normal lipid profile but the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of serum uric acid in acute ischaemic stroke

et al. 2017

View full text Add to dashboard Cite

Background: The role of serum uric acid as a risk factor for acute ischaemic stroke is controversial and there is little information about it. Present study was done to estimate serum uric acid levels in patients of acute ischaemic stroke and to assess its risk factor potential.Methods: It was a prospective case control study carried out in the department of Medicine at Sri Guru Ramdas Institute of Medical Sciences and Research, Vallah, Sri Amritsar, Punjab, India from January 2015 to July 2016. 50 cases of acute ischaemic stroke were enrolled and were compared with same number of age and sex matched healthy controls. Serum uric acid levels were measured in cases (within 24 hours of stroke evolution). Glasgow coma scale (GCS) score was calculated for cases at time of admission. The results were statistically analysed.Results: Mean serum uric acid level in cases was 6.15±1.91mg/dl whereas it was 5.1±1.4 mg/dl in controls. The difference of serum uric acid levels between cases and controls was statistically significant (p = 0.0054). Patients with poor GCS had higher mean serum uric acid levels as compared to patients with mild or moderate GCS score which was statistically significant(p = 0.0426).Conclusions: Serum uric acid can be used as a marker for increased risk of stroke. Furthermore, serum uric acid can also be used for risk stratification after stroke.

show abstract

Serum Uric Acid as an Independent Predictor of Early Death After Acute Stroke

Cited by 117 publications

References 94 publications

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Association of Serum Bilirubin with Ischemic Stroke Outcomes

Evaluation of serum uric acid in acute ischaemic stroke

Contact Info

Product

Resources

About