2016
DOI: 10.1159/000448629
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Serum Uric Acid Exhibits Inverse Relationship with Estimated Glomerular Filtration Rate

Abstract: Background: In this study, we investigated the relationship between serum uric acid (SUA) and renal function in a unique patient cohort wherein SUA levels fluctuate during the course of standard care. Methods: Correlation coefficients between SUA and serum creatinine (SCr) and kinetic estimated GFR (KeGFR) were retrospectively investigated in acute myeloid leukemia (AML) patients, and statistically significant and clinically relevant determinants were studied in multiple regression models. Results: One hundred… Show more

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Cited by 20 publications
(10 citation statements)
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“…In order to confirm the previously reported relationship between uric acid and estimated GFR in cardiac surgery patients, it is investigated the relationship between SUA and KeGFR in a larger, unique patient cohort wherein SUA levels fluctuate during the course of standard care. Koratala et al retrospectively studied acute myeloid leukemia patients [45]. The unique characteristic of this cohort was that all of the patients were managed with the same clinical protocols, i.e., they were admitted to the hospital with a confirmed diagnosis of AML, underwent laboratory, imaging and cytogenetic testing, received prophylactic therapy with bicarbonate containing fluids and oral uric acid lowering medications, and then received induction therapy.…”
Section: Uric Acid In Acute Kidney Injurymentioning
confidence: 99%
“…In order to confirm the previously reported relationship between uric acid and estimated GFR in cardiac surgery patients, it is investigated the relationship between SUA and KeGFR in a larger, unique patient cohort wherein SUA levels fluctuate during the course of standard care. Koratala et al retrospectively studied acute myeloid leukemia patients [45]. The unique characteristic of this cohort was that all of the patients were managed with the same clinical protocols, i.e., they were admitted to the hospital with a confirmed diagnosis of AML, underwent laboratory, imaging and cytogenetic testing, received prophylactic therapy with bicarbonate containing fluids and oral uric acid lowering medications, and then received induction therapy.…”
Section: Uric Acid In Acute Kidney Injurymentioning
confidence: 99%
“…Increased sUA seems to be related to decreased estimated glomerular filtration rate (eGFR). 70 71 This is probably related to sUA affecting blood pressure, 72 which may be caused by increased vascular stiffness. 73 74 Reducing sUA may therefore have beneficial effect on susceptibility towards cardiovascular disease and diminished renal function.…”
Section: Discussionmentioning
confidence: 99%
“…The original algebraic equation has been tested extensively in clinical research and has performed admirably. 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 In 2018, the GFR K equation was upgraded with calculus to accommodate a volume that changes steadily. 3 To remodel the algebraic into a calculus version, we had to figure out the exact substitute for the mean.…”
Section: Mean [Cr] Reduxmentioning
confidence: 99%