Serum uric acid in traditional Pacific Islanders and in Swedes

Lindeberg, Staffan; Cordain, Loren; Råstam, Lennart; Åhrén, Bo

doi:10.1046/j.1365-2796.2003.01272.x

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Standard methods were used for measurements of weight, standing height, waist circumference, triceps skinfold (TSF) thickness, upper mid-arm circumference (MAC) and serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL), triglycerides (TG) and uric acid [23-25]. Blood pressure was measured with subjects in the sitting position.…”

Section: Methodsmentioning

confidence: 99%

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Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea

et al. 2007

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ObjectiveTo determine the importance of IgM antibodies against phosphorylcholine (aPC), a novel protective factor for cardiovascular disease (CVD), in a population with a non-western life style as compared with a Swedish control group.Methods and resultsRisk factors for cardiovascular disease were determined in a group of 108 individuals aged 40–86 years from New Guinea and 108 age-and sex-matched individuals from a population based study in Sweden. Antibodies were tested by ELISA. aPC IgM levels were significantly higher among New Guineans than among Swedish controls (p < 0.0001). This difference remained significant among both men and women when controlled for LDL and blood pressure which were lower and smoking which was more prevalent in New Guineans as compared to Swedish controls (p < 0.0001). aPC IgM was significantly and negatively associated with age and systolic blood pressure among Swedish controls and with waist circumference among New Guineans. aPC IgM levels were significantly higher among women than men in both groups. The proportion of the saturated fatty acid (FA) myristic acid in serum cholesterol esters was negatively but polyunsaturated eicosapentaenoic acid and also lipoprotein (a) were positively associated with aPC IgM levels.ConclusionIgM-antibodies against PC, which have atheroprotective properties, are higher in a population from Kitava, New Guinea with a traditional lifestyle, than in Swedish Controls, and higher among women than men in both populations tested. Such antibodies could contribute to the low incidence of cardiovascular disease reported from Kitava and could also provide an explanation as to why women have a later onset of CVD than men.

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Section: Methodsmentioning

confidence: 99%

“…Blood pressure was measured with subjects in the sitting position. In Kitava, the measurement arm was kept parallel to the sternum, thus identical to another Swedish control population [23-25]. In contrast, in the Skaraborg survey, the measurement arm was at heart level.…”

Section: Methodsmentioning

confidence: 99%

Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea

et al. 2007

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“…In this age-based study, young patients (21-30 years) and old patients (51-60 years) showed consistent improvement, at week 2 and week 4 compared to age category of 31 to 40 years and 41 to 50 years that experienced a decrease in uric acid levels at week 4. The results of this study showed that elevated levels of uric acid were not affected by age factors thus an age influence was negligible and elevated serum uric acid levels were more dominant due to OAT administration 15 .…”

Section: Discussionmentioning

confidence: 65%

Factors Affecting Uric Acid Changes in Pulmonary Tuberculosis Patients Who Received Oral Anti Tuberculosis Therapy During One Month

2020

MLU

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Background: Pyazinamide (PZA) and Ethambutol (ETB) are tuberculosis drugs that can increase uric acid levels by decreasing excretion and increasing uric acid reabsorption. Increased levels of uric acid can cause arthritis, arthralgia and gout.Objective: To evaluate the association of uric acid levels with age, sex and body mass index (BMI) and arthralgia incidence. Method:The study was conducted in the lung outpatient treatment room at the Department of Pulmonology and Respiratory Medicine. Method were uric acid levels examination before OAT administration, at week 2 and 4. Paired t tests and spearman correlation test were used to analyze the association between sex, age, BMI and arthralgia with increased uric acid levels. The incidence of hyperuricemia and arthralgia were performed in percentage.Result: Seventeen subjects consisting of 9 (52.9%) males and 8 (47.1%) females who received oral antituberculosis category 1 mostly had normal BMI prior to treatment (9 patients, 52.9%). Uric acid levels increased significantly (p <0.005) at week 2 and 4 than before Oral Anti Tuberculosis (OAT) treatment. It was found significant relationship (p <0.005) between increased uric acid levels and arthralgia with hyperuricemia incidence of 82.35% and arthralgia incidence of 35.29%. There was no significant association (p <0.005) between increased uric acid levels with sex, age and BMI. Conclusion:It was found a high incidence of hyperuricemia (82.3%) in ETB and PZA treatment while symptomatic 35.29%.

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2009

Food and Western Disease

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Serum uric acid in traditional Pacific Islanders and in Swedes

Cited by 6 publications

References 31 publications

Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea

Atheroprotective natural anti-phosphorylcholine antibodies of IgM subclass are decreased in Swedish controls as compared to non-westernized individuals from New Guinea

Factors Affecting Uric Acid Changes in Pulmonary Tuberculosis Patients Who Received Oral Anti Tuberculosis Therapy During One Month

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