Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

Shatat, Ibrahim F.; Abdallah, Rany T.; Sas, David J.; Hailpern, Susan M.

doi:10.1038/pr.2012.47

Cited by 29 publications

(18 citation statements)

References 32 publications

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“…According to the NHANES 2005-2008, the mean UA levels and the 95th percentile were 5.80 and 8.10 mg/dL, respectively, in white male adolescents and 4.50 and 6.10 mg/dL, respectively, in white female adolescents. 20) In a previously conducted Chinese study, the median UA levels were 5.8 and 4.3 mg/dL in male and female adolescents, respectively. 21) In our study, differences in UA levels based on sex were observed among the subjects.…”

Section: Discussionmentioning

confidence: 92%

Serum uric acid in Korean children and adolescents: reference percentiles and association with metabolic syndrome

Cho¹,

Kim²,

Yoon³

et al. 2020

Ann Pediatr Endocrinol Metab

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To establish age/sex-specific reference intervals for serum uric acid and to examine the associations between serum uric acid level and metabolic syndrome (MetS) and its components in Korean children and adolescents. Methods: We analyzed data for 1,349 subjects aged 10 to 19 years from the Korea National Health and Nutrition Examination Survey 2016-2017. Results: The mean uric acid levels were 5.9±1.3 mg/dL (interquartile range, 5.0-6.8 mg/dL) in males and 4.6±0.9 mg/dL (interquartile range, 3.9-5.2 mg/dL) in females. The mean uric acid level increased significantly from 10-13 years of age in males, but not in females. The overall prevalence of MetS was 5.9% (7.3% in males and 4.3% in females; P=0.022). The prevalences of MetS in the lowest, second, third, and highest quartiles of uric acid level were 4.4%, 3.3%, 6.1%, and 15.2%, respectively, in males (P for trend <0.001) and 1.9%, 0.0%, 4.1%, and 10.9%, respectively, in females (P for trend <0.001). Compared with the lowest quartile of uric acid level, the odds ratio (with 95% confidence interval) for MetS in the highest quartile was 2.897 (1.140-7.361) in males and 5.173 (1.459-18.342) in females. Subjects in the highest quartile exhibited increased risk for abdominal obesity and low high-density lipoprotein cholesterol in both sexes. Conclusion: Serum uric acid level is positively associated with MetS and its components abdominal obesity and low high-density lipoprotein cholesterol.

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Section: Discussionmentioning

confidence: 92%

Serum uric acid in Korean children and adolescents: reference percentiles and association with metabolic syndrome

Cho¹,

Kim²,

Yoon³

et al. 2020

Ann Pediatr Endocrinol Metab

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“…The higher uric acid and bilirubin concentrations in adults could be explained as a protective response to increased phagocytosis of senescent erythrocytes and the higher ROS generation [ 77 , 78 ] compared with children. Additionally, the higher uric acid in adults in the present study could also be due to increased intake of purine-rich foods [ 77 , 79 , 80 ], older age, higher BMI, greater height, and greater weight compared to children [ 79 ]. The differences in antioxidant status between adults and children of the present study were apparent at rest, but also during the recovery period after eccentric exercise.…”

Section: Discussionmentioning

confidence: 99%

Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children

Deli

Fatouros

Paschalis

et al. 2017

Oxidative Medicine and Cellular Longevity

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Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n = 14) and children (n = 11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p < 0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619.

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“…Children were categorized as having elevated or normal serum UA based on age-sex-race 95 th percentile norms [18, 19]. All routine clinical tests, except for plasma renin activity and serum aldosterone, were performed in the Johns Hopkins Hospital clinical laboratory.…”

Section: Methodsmentioning

confidence: 99%

“… SD indicates standard deviation; IQR, interquartile range; UA, uric acid; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; BPi, blood pressure index = (BP/95 th percentile BP or 140/90 if ≥ 18 yrs); HDL, high density lipoprotein cholesterol; ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker; hsCRP, high sensitivity C-reactive protein; LVM, left ventricular mass; LVMI, left ventricular mass index = LVM/ht(m 2.7 ); LVH, left ventricular hypertrophy = LVMI≥95 th percentile a Normal UA defined as a serum UA <95 th percentile for age, race and sex using Harriet Lane Handbook cutoffs for <12 years [18]; NHANES for 12-19 years [19]. Elevated UA is defined as ≥95th percentile.…”

Section: Figurementioning

confidence: 99%

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Elevated uric acid and obesity-related cardiovascular disease risk factors among hypertensive youth

et al. 2015

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Background Uric acid (UA) is associated with high blood pressure in adolescents and left ventricular hypertrophy (LVH) and cardiovascular disease (CVD) in adults. We sought to determine if UA is independently associated with CVD risk factors and left ventricular mass (LVM) over time in hypertensive youth. Methods One-year prospective observational study of hypertensive children aged 3-19 years. Cross-sectional and longitudinal associations of serum UA with CVD risk factors and LVM were explored. Results At baseline: mean age 13.8 years, mean UA 5.5 mg/dL, 24 % with elevated UA, 51 % overweight/obese, and 39 % with LVH. Measures of adiposity, low high-density lipoprotein cholesterol, high-sensitivity CRP, LVM and LVH were all significantly associated with elevated UA at baseline, but not with change over time. Each 1 mg/dL increase in baseline UA was associated with 2.5 g/m2.7 greater LVM index at follow-up (95% CI 0.64, 4.39; p=0.01); after adjustment for age, sex, race, body mass index z-score, change in UA, time, BP and medication use, this association was no longer significant. Conclusions Hypertensive children with elevated UA have a higher prevalence of obesity-related CVD risk factors. Among hypertensive children, UA may be a marker of adiposity and not an independent CVD risk factor.

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Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors

Cited by 29 publications

References 32 publications

Serum uric acid in Korean children and adolescents: reference percentiles and association with metabolic syndrome

Serum uric acid in Korean children and adolescents: reference percentiles and association with metabolic syndrome

Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children

Elevated uric acid and obesity-related cardiovascular disease risk factors among hypertensive youth

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