Serum Uric Acid Is Independently Associated with Risk of Obstructive Sleep Apnea-Hypopnea Syndrome in Chinese Patients with Type 2 Diabetes

Abstract

Purpose. We aimed to investigate the association between serum uric acid (SUA) levels and obstructive sleep apnea-hypopnea syndrome (OSAHS) in patients with type 2 diabetes. Methods. A cross-sectional study of 212 type 2 diabetes mellitus (T2DM) patients was conducted in Xiamen, China. All patients underwent polysomnography (PSG) recordings for OSAHS diagnosis. Patients were grouped according to the apnea-hypopnea index (AHI) as mild (5-14.9), moderate (15-29.9), and severe (≧30) OSAHS. Patients with AHI≤4.9 served as the control group. Weight, body mass index (BMI), SUA, liver function, renal function, blood pressure, lipid profiles, and glycemic parameters were measured. Results. A total of 158 patients (101 men and 57 women) with complete data were analyzed in this study. 127 patients were identified as OSAHS. Among the 127 patients with OSAHS, 56 (44.1%), 37 (29.1%), and 34 (26.8%) had mild, moderate, and severe OSAHS, respectively. Correlation analyses showed that the SUA level was significantly related to the apnea-hypopnea index (AHI) (r=0.194, p=0.016). The level of SUA was significantly higher among OSAHS patients compared to the control group (control group: 333.14±80.52 μmol/L, mild group: 345.50±90.27 μmol/L, moderate group: 363.59±134.26 μmol/L, and severe group: 428.37±123.58 μmol/L and p=0.029). Multivariable logistic regression analyses showed that SUA was the independent risk factor for OSAHS (OR: 1.006, 95% CI: 1.001-1.011, p=0.020). Conclusions. The SUA level is significantly associated with the severity of OSAHS and should be controlled when managing OSAHS.

Usefulness of Cathepsin S to Predict Risk for Obstructive Sleep Apnea among Patients with Type 2 Diabetes

“…In addition, our study showed that serum uric acid expression was significantly higher in the OSA&non-T2D group than in the control group, which was in accord with the previous research [ 29 , 30 ]. Meanwhile, serum uric acid levels were significantly reduced after OSA treatment with continuous positive airway pressure or weight reduction [ 31 ].…”

Higher Apnea-Hypopnea Index (AHI) and Oxygen Desaturation Index (ODI) Were Independently Associated with Increased Risks of Hypertension in Patients with T2DM: A Cross-Sectional Study

“…An observational study conducted in T2DM patients found that the prevalence rate of OSAS was 86%, of which the moderate and severe OSAS were 30.5% and 22.6%, respectively [ 7 ]. Our previous study also found 80.3% of T2DM patients had OSAS which was consistent with others [ 8 ]. A community-based study indicated that OSAS was independently related to the development of insulin resistance and could promote the occurrence of T2DM [ 9 ].…”

Hyperuricemia, the heart, and the kidneys – to treat or not to treat?

“…They reported an increase in SUA of 0.3 mg/dL and gout odds ratio of 2.24 for each increase in genetically predicted BMI of 4.6 kg/m 2 [ 23 ]. Another factor that has shown an association with higher SUA is obstructive sleep apnea–hypopnea syndrome (OSAHS) [ 24 ]; however, meta-analyses have not revealed an effect of using continuous positive airway pressure (CPAP) in OSAHS on SUA levels [ 25 ].…”