Serum uric acid is positively associated with muscle strength in older men and women: Findings from NHANES 1999–2002

Nahas, Paula C.; Rossato, Luana T.; Branco, Flávia M.S. de; Azeredo, Catarina Machado; Rinaldi, Ana Elisa Madalena; Oliveira, Erick P. de

doi:10.1016/j.clnu.2020.12.043

Cited by 42 publications

(21 citation statements)

References 35 publications

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“…On the other hand, consistent with our ndings, a Korean study excluding eGFR < 60 populations extracted data from KNHANES 2016 indicated that SUA is positively associated with increased grip strength in the elderly [22]. Nahas et al, adjusting eGFR and other confounders, showed that older men and women could take advantage of a high SUA level with better handgrip strength [15]. Thus, the present study and the abovementioned studies suggested that a better eGFR level may be a protective factor for serum uric acid levels to improve muscular strength.…”

Section: Discussionsupporting

confidence: 89%

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Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

Huang

Chen

Duan

et al. 2022

Preprint

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BackgroundWe aimed to investigate the interaction between serum uric acid levels with estimated glomerular filtration rate (eGFR) to low muscle strength (LMS) in a large Chinese elderly population.MethodsCohort data were obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Two thousand seven hundred forty-five community-dwelling older participants were enrolled for the follow-up. Serum uric acid was collected after 8 hours of fasting, and handgrip strength was measured with a dynamometer. eGFR was calculated with an equation based on the Chinese population. A generalized additive model was employed for interaction analysis and progressively adjusted confounders.ResultsIn this study, we found that men with a low eGFR (<60 mL/min/1.73 m2) reported higher SUA levels (5.91 ± 1.27) and older (72.53 ± 6.38) than those who had a high eGFR while women share the same difference with a lower eGFR in higher SUA levels (5.00 ± 1.34) and older (72.81 ± 6.83). After progressively adjusting covariates, in females, the OR for higher eGFR with higher SUA level remained significantly with low muscle strength (OR=0.80 95%CI=0.68-0.95 P=0.0102). This correlation, however, was not observed in men.ConclusionsThis population-based cohort study in Chinese revealed that high serum uric acid level with higher eGFR seems to be significantly associated with a lower risk of low muscle strength in the elderly, especially in females.

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Section: Discussionsupporting

confidence: 89%

“…A crosssectional study using data from the WCHAT suggested that SUA level was positively correlated with muscle strength [14]. Moreover, A NHANES study supported the same result that SUA level could be a protective factor for muscle strength in the elderly [15]. Contrastingly, a cohort PRO.V.A.…”

Section: Introductionmentioning

confidence: 88%

Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

Huang

Chen

Duan

et al. 2022

Preprint

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“…Uric acid acts as an antioxidant, meaning that increased levels of uric acid could potentially protect against the uncontrolled production of free radicals [ 59 ]. Rises in uric acid levels in serum have been shown to increase handgrip strength and lead to greater muscle function in elderly people [ 51 , 52 , 53 ], which could perhaps decelerate the progression of sarcopenia.…”

Section: Biomarkers With Increased Concentration In Sarcopeniamentioning

confidence: 99%

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

et al. 2022

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Due to the multifactorial pathogenesis of sarcopenia, it is crucial to identify biomarkers that are risk factors for sarcopenia, and which therefore have a prognostic function. Aim: This narrative review aims to define a set of biomarkers associated with nutrition and sarcopenia. These biomarkers could contribute to individualized monitoring and enable preventive and therapeutic methods. Methods: Two electronic databases, PubMed and Google Scholar, were used. The search strategy was based on a controlled vocabulary (MeSH) and includes studies published up to February 2022. Discussion: Higher levels of serum uric acid are associated with higher handgrip strength and better muscle function in elderly people and, thus, may slow the progression of sarcopenia. Leptin, an adipokine secreted by adipose tissue, promotes the production of pro-inflammatory cytokines, which in turn lead to sarcopenia. This makes leptin a significant indirect biomarker for physical disability and sarcopenic obesity. Additionally, creatinine is a reliable biomarker for muscle mass status because of its easy accessibility and cost-effectiveness. Vitamin D status acts as a useful biomarker for predicting total mortality, hip fractures, early death, and the development of sarcopenia. Therefore, there is an increasing interest in dietary antioxidants and their effects on age-related losses of muscle mass and function. On the other hand, 3-Methylhistidine is a valuable biomarker for detecting increased muscle catabolism, as it is excreted through urine during muscle degradation. In addition, IGF-1, whose concentration in plasma is stimulated by food intake, is associated with the loss of skeletal muscle mass, which probably plays a crucial role in the progression of sarcopenia. Conclusions: Many nutritional biomarkers were found to be associated with sarcopenia, and can therefore be used as prognostic indexes and risk factors. Nutrition plays an important role in the prevention and management of sarcopenia, affecting muscle mass, strength, and function in elderly people.

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“…Studies that have evaluated associations between muscle loss and serum UA levels have often been limited in their ability to account for the confounding effects of adiposity, since muscle mass and fat mass are tightly correlated with each other (i.e., individuals who are more obese are expected to have greater muscle mass) (13). Some studies have shown that higher serum UA levels are associated with better muscle function and greater muscle mass (14,15). However, others have presented conflicting observations.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Low Serum Urate, Body Composition, and Mortality

Baker

Weber

Neogi

et al. 2022

Arthritis & Rheumatology

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Objective Controversy remains as to whether low serum urate or uric acid (UA) levels contribute to adverse outcomes. We evaluated the relation between low serum UA levels and sarcopenia and assessed whether sarcopenia confounds associations between these low levels and mortality. Methods We utilized data from the National Health and Nutrition Examination Survey (1999–2006). Participants with available whole‐body dual x‐ray absorptiometry body composition measurements and serum UA concentrations were included. Body composition assessments included body mass index (BMI), waist circumference, maximum lifetime BMI, and age‐, sex‐, and race‐specific appendicular lean mass index (ALMI) and fat mass index (FMI) Z scores. We also calculated Z scores for ALMI relative to FMI (ALMIFMI). We evaluated associations between serum UA levels and body composition using logistic regression and assessed associations between serum UA levels and mortality before and after adjusting for differences in body composition using Cox proportional hazards regression. Results Among the 13,979 participants, low serum UA concentrations (<2.5 mg/dl in women, <3.5 mg/dl in men) were associated with low lean mass (ALMI and ALMIFMI Z scores), underweight BMI (<18.5 kg/m2), and higher rates of weight loss. The proportion of patients with low ALMI Z scores was 29% in the low serum UA group and 16% in the normal serum UA group (P = 0.001). Low serum UA levels were associated with increased mortality before we adjusted for body composition (hazard ratio 1.61 [95% confidence interval 1.14–2.28]; P = 0.008) but was attenuated and not significant after adjustment for body composition and weight loss (hazard ratio 1.30 [95% confidence interval 0.92–1.85], P = 0.13). Conclusion Sarcopenia and weight loss are more common among patients with low serum UA concentrations. Differences in body composition may help to explain associations between low levels of serum UA and higher mortality.

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Serum uric acid is positively associated with muscle strength in older men and women: Findings from NHANES 1999–2002

Cited by 42 publications

References 35 publications

Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study

Nutritional and Nutrition-Related Biomarkers as Prognostic Factors of Sarcopenia, and Their Role in Disease Progression

Associations Between Low Serum Urate, Body Composition, and Mortality

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