Serum uric acid level in patients of acute stroke

Prasad, Chandan; Dwivedi, N.C.; Gupta, Poonam; Shukla, Shubhangi; Shukla, Rita; Yadav, Rakesh Kumar; Verma, Sujit Kumar

doi:10.18203/2349-3933.ijam20161098

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…It has been reported that increased levels of uric acid are associated with established cardiovascular risk factor such as elevated serum triglyceride and cholesterol concentration, hypertension, obesity, insulin resistance and metabolic syndrome [9, 12]. The role of SUA in acute stroke is poorly understood since some studies demonstrate that SUA is associated with adverse outcomes and mortality [13-18] while other studies are suggesting that SUA may be beneficial and protect against poor outcomes [19, 20]. Despite these controversies as to whether there is a relation between SUA levels and outcome after acute stroke, the role of SUA in the acute phase of hemorrhagic stroke only has received scant attention in world literature.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans

Mapoure¹,

Ayeah²,

Hamadou³

et al. 2019

Pan Afr Med J

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Introduction Very few studies have been conducted to evaluate the prevalence of hyperuricemia and its impact on the prognosis amongst acute hemorrhagic stroke (AHS) patients. The objectives was to determine the prevalence of hyperuricemia in AHS patients and examined the association between hyperuricemia and stroke outcomes in the Douala General Hospital (DGH). Methods This was a hospital based prospective cohort which included AHS patients with baseline SUA levels and 3 months post stroke follow-up data. SUA values were divided into quintiles. Associations between hyperuricemia and stroke outcomes were analyzed using multiple logistic regression and survival analysis (cox regression and Kaplan Meier). Results A total of 221 AHS patients were reviewed with a mean age of 55.8±11.8 years. The prevalence of hyperuricemia among AHS patients was 34.4% with mean SUA level of 376.8±131.9 μmol/l. On multivariate analysis, hyperuricemia was not independently associated with early death [(OR = 1.072 (CI: 0.370-3.056; p = 0.897)] and poor functional outcome [(OR=2.487 (CI: 0.771-8.699; p = 0.154)] after hemorrhagic stroke. No significant increase in stroke deaths was observed across higher SUA quintiles amongst hemorrhagic stroke patients (p = 0.326). No statistically significant correlation was observed between SUA level and NIHSS (r = 0.063, p = 0.353) and between SUA level and mRS (r = 0.030, p = 0.662) in hemorrhagic stroke. Conclusion About one third of patients present with hyperuricemia in the acute phase of hemorrhagic stroke. Hyperuricemia can act as risk factor for stroke because of its relationship with CVRFs but hyperuricemia has no impact on the severity and short-term outcome amongst black African hemorrhagic stroke patients.

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Section: Introductionmentioning

confidence: 99%

The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans

Mapoure¹,

Ayeah²,

Hamadou³

et al. 2019

Pan Afr Med J

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Serum uric acid concentrations and risk of intracerebral hemorrhage: A systematic review and meta-analysis

et al. 2018

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Total antioxidant status of blood in various types of ischemic stroke

Kravtsov¹,

Kravtsova²,

Selezneva³

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Patients in the control group AOS was 1.69±0.17 mmol/L (median 1.72, interquartile range 1.53-1.83 mmol/L). With the development of IS AOS was 1.15±0,41 mmol/L (median 1.12; interquartile range 0.84-1.45 mmol/L) (p=0.000001). In groups with different pathogenetic mechanism of the IS value of the AOS was lower than in the control group and accounted for atherothrombotic variant (1.24; 0.98-1.67 mmol/L) (p=0.000001), for cardioembolic (p=0.000031), and for lacunar (1.24; 0.98-1.67 mmol/L) (p=0.035044). The value of the AOS was not significantly differ between men and women and was independent on the age and location of the ischemic lesion. Reduced AOS serum indicates an imbalance between prooksidatnoy and antioksidatnoy system in the formation of any pathogenic forms of IS. The decrease of AOS in blood serum indicates the balance between prooxidative and antioxidative system in the formation of any pathogenic forms of AI.

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Serum uric acid level in patients of acute stroke

Cited by 3 publications

References 11 publications

The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans

The prognostic value of serum uric acid in the acute phase of hemorrhagic stroke patients in black Africans

Serum uric acid concentrations and risk of intracerebral hemorrhage: A systematic review and meta-analysis

Total antioxidant status of blood in various types of ischemic stroke

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