Serum uric acid levels correlate with benign paroxysmal positional vertigo

Çelikbilek, Asuman; Gencer, Zeliha Kapusuz; Saydam, Levent; Zararsız, Gökmen; Tanık, Nermin; Özkırış, Mahmut

doi:10.1111/ene.12248

Cited by 31 publications

(41 citation statements)

References 38 publications

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“…A case–control histopathological human temporal bone study found that the prevalence of cupular and free‐floating deposits in the lateral and posterior semicircular canals was significantly higher in individuals with type 1 diabetes mellitus than in the temporal bones of normal age‐matched controls . Another systemic link was described recently wherein lipid profiles and serum uric acid levels were found to be higher in individuals with BPPV than in controls . Other conditions that have been associated with BPPV include chronic thyroiditis, hypertension, hyperlipidemia, stroke, atherosclerosis, and osteoporosis.…”

Section: Etiological Factorsmentioning

confidence: 98%

“…30 Another systemic link was described recently wherein lipid profiles and serum uric acid levels were found to be higher in individuals with BPPV than in controls. 31 Other conditions that have been associated with BPPV include chronic thyroiditis, 32 hypertension, hyperlipidemia, stroke, 2 atherosclerosis, 33 and osteoporosis. To find a statistical link between common comorbidities affecting older adults (hypertension, diabetes mellitus, osteoarthrosis, osteoporosis, and depression) and recurrent episodes of BPPV, data from more than 1,000 individuals with BPPV in 11 centers in seven countries were examined in a recent study.…”

Section: Etiological Factorsmentioning

confidence: 99%

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A Geriatric Perspective on Benign Paroxysmal Positional Vertigo

Parham

Kuchel

2016

J American Geriatrics Society

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Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo in older adults. Beyond the unpleasant sensation of vertigo, BPPV also negatively affects older adults' gait and balance and increases their risk of falling. As such it has a profound effect on function, independence, and quality of life. Otoconia are the inner ear structures that help detect horizontal and vertical movements. Aging contributes to the fragmentation of otoconia, whose displacement into the semicircular, most commonly posterior canals, can produce rotatory movement sensations with head movement. BPPV is more commonly idiopathic in older adults than in younger individuals, can present atypically, and has a more-protracted course and higher risk of recurrence. Medications such as meclizine that are commonly prescribed for BPPV can be associated with significant side effects. Dix-Hallpike and Head Roll tests can generally identify the involved canal. Symptoms resolve as otoconia fragments dissolve into the endolymph, but appropriate canalith repositioning (e.g., Epley maneuver) can expedite recovery and reduce the burden of this disorder. Observations suggesting an association between idiopathic BPPV and vitamin D deficiency and osteoporosis indicate that BPPV may share risk factors with other common geriatric conditions, which highlights the importance of moving beyond purely otological considerations and addressing the needs of older adults with vertigo through a systems-based multidisciplinary approach.

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Section: Etiological Factorsmentioning

confidence: 98%

Section: Etiological Factorsmentioning

confidence: 99%

A Geriatric Perspective on Benign Paroxysmal Positional Vertigo

Parham

Kuchel

2016

J American Geriatrics Society

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“…As we all know, age, gender, sex hormones, osteoporosis, hypertension, hyperlipidemia, diabetes and hyperuricemia are all considered as risk factors of BPPV (6)(7)(8)(9). According to previous study that cerebrovascular risk factors in uenced BPPV recurrence (10).…”

Section: Discussionmentioning

confidence: 99%

Unhealthy lifestyle is an important risk factor for BPPV recurrence

Fu¹,

Zhang²,

Jin³

et al. 2020

Preprint

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Background: Benign paroxysmal positional vertigo (BPPV) is self-limiting and recurrent but the cost is considerable. The recurrence of BPPV increased significantly under the quarantine policy in Hangzhou. The unhealthy lifestyle risk factors of the recurrence of BPPV have not yet been investigated. So, the objective is to analyze the unhealthy lifestyle risk factors of recurrent BPPV.Methods: A retrospective observational study was conducted in the Department of Neurology in Tongde Hospital of Zhejiang Province from December 2018 to March 2020. The study included 186 patients aged 23–86 years. All patients received the definitive diagnosis and canalith repositioning maneuvers (CRM) treatment and finally accomplished follow-up for one year. Demographic variables, potential recurrence risk factors, neurological examination, cranial computed tomography and lifestyle were assessed.Data Analyses: The t-test or chi-squared test was first performed for group comparison, then logistic regression analysis was performed to investigate the recurrence risk factors in all of the patients.Results: The 1-year recurrence rates of BPPV patients after reposition maneuvers were 36.02%, is significantly higher than other study especially in the first quarter of 2020 (38.8% of patients with BPPV recurrence). Logistic regression analysis shows that BPPV patients who was poor physical activities and prolonged recumbent position time have more recurrence risks. Poor physical activities (odds ratio =5.690, 95% confidence interval: 1.650-19.618, p <0.006), prolonged recumbent position time (odds ratio = 1.651, 95% confidence interval: 1.370-2.003, p = 0.000), were risk factors for the recurrence of BPPV in patients.Conclusion: We conclude that poor physical activities and prolonged recumbent position time may be independent risk factors for the recurrence of BPPV patients, but aging, Ménière’s disease, sudden deafness migraine, hypertension, hyperlipemia, diabetes, CHD, POCI, mental factors, and mental labor do not increase the recurrence risk.

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“…One study found patients with BPPV had higher serum uric acid levels than controls15: hyperuricaemia-associated crystal formation in the semicircular canals makes an attractive hypothesis, and although not universally reproduced16 is certainly a potential mechanism 17 18…”

Section: Pathophysiologymentioning

confidence: 99%

Epley and beyond: an update on treating positional vertigo

Kaski

Bronstein

2014

Pract Neurol

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Benign paroxysmal positional vertigo (BPPV) is the commonest cause of dizziness. It is characterised by brief episodes of vertigo and imbalance with nystagmus. The direction of nystagmus allows the identification of the culprit semicircular canal. As it is readily treatable--and often curable--BPPV should not be missed. Although recurrent episodes of vertigo triggered by movement suggest BPPV, the diagnosis can only be confirmed with the Dix-Hallpike manoeuvre. Here we review the diagnostic manoeuvres required to diagnose BPPV, and the various repositioning manoeuvres for treating different types of BPPV.

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Serum uric acid levels correlate with benign paroxysmal positional vertigo

Abstract: Elevated SUA is positively correlated with BPPV, requiring further efforts to clarify the exact mechanism.

Cited by 31 publications

References 38 publications

A Geriatric Perspective on Benign Paroxysmal Positional Vertigo

A Geriatric Perspective on Benign Paroxysmal Positional Vertigo

Unhealthy lifestyle is an important risk factor for BPPV recurrence

Epley and beyond: an update on treating positional vertigo

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