Serum uric acid levels in hypertensive patients with and without metabolic syndrome in the hills of Himachal Pradesh, India

Raina, Sujeet; Thakur, Surender; Thakur, Shruti; Negi, PC; Verma, Balbir S

doi:10.4103/2347-9906.141143

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…Decreased renal blood flow and decreased tubular secretion of uric acid have been associated with 34,35 high serum uric acid with hypertension. Study result came out regarding high incidence of hyperuricemia in hypertensives also revealed in other studies done by Sujeet Raina, Surender Thakur, Surinder, Thakur et al, 36 the findings which were similar with our study. Hyperuricemia is really not uncommon, the prevalence of which were reported between 2.6% and 47.2% in various populations.…”

Section: Discussionsupporting

confidence: 92%

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Study of Serum Uric Acid Level in Patients with SystemicEssential Hypertension in the Context of New 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline

Ghosh¹,

Pal²,

Debbarma³

et al. 2020

jemds

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BACKGROUND Hypertension poses a challenge to public health as well as to the medical science. Final metabolite of purine in humans is uric acid, increased serum level of which is associated with cardio-renal risk, although serum uric acid (SUA) level appears to have different effects on blood pressure (BP), depending on level and how long subjects were exposed. We wanted to study the association between hyperuricemia and hypertension, in various aspects, in the context of new 2017 ACC/ AHA High Blood Pressure Clinical Practice Guidelines. METHODS The study was conducted in a tertiary care hospital, Agartala, Tripura. It is a case control study. SUA estimation was in 160 hypertensive patients and 160 normotensive controls, by using uricase method. SPSS version 24 was used for data entry and analysis. Chi square test and unpaired t test were used, wherever applicable. RESULTS Out of 320 subjects, who were included in the study, 160 subjects were hypertensive and 160 subjects were normotensive. There was strong association between hypertension and hyperuricemia. Hyperuricemia is more common in males and in patients with stage II hypertension. CONCLUSIONS The association between hyperuricemia and hypertension, has long been recognized. It remains unresolved whether the association of high uric acid level with high blood pressure is solely because of the underlying renal and metabolic abnormalities. Association of hyperuricemia and hypertension indicated that, hyperuricemia might be a target for the proposed therapeutic evaluation for the prevention of hypertension and provided impetus for the future design research work including interventional studies.

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Section: Discussionsupporting

confidence: 92%

“…Hyperuricemia was more frequent found in male (14.4%) as compared to female (12.8%). 36 In our study we could find as compared to normotensives, hyperuricemia is more prevalent in hypertensive subjects. Patients with increased uric acid level may be more responsive to the uric acid lowering treatment, early in the course of their disease.…”

Section: Discussionsupporting

confidence: 50%

Study of Serum Uric Acid Level in Patients with SystemicEssential Hypertension in the Context of New 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline

Ghosh¹,

Pal²,

Debbarma³

et al. 2020

jemds

View full text Add to dashboard Cite

show abstract

“…Anand et al 7 they discussed that the strength of association of uric acid with hypertension decreases with increase in age of the participants, suggesting Uric acid might have a role in causation of early onset hypertension in young subjects. This statement was supported by another study done by Sujeet Raina et al 8 Alteration in serum lipid levels has been identified as an independent risk factor for essential hypertension. Halperin et al 13 showed that dyslipidemia in apparently healthy individuals leads to hypertension.…”

Section: Discussionmentioning

confidence: 55%

“…5 In various studies on hypertension, hyperuricemia as a risk factor, marker was extensively studied. [6][7][8][9] According to Canon et al serum uric acid levels greater than 6.5 mg/dl has been found in 25-40% of their hypertensive patients and a serum uric acid concentration of 5.5 mg/dl was found in the remaining 60% of hypertensive patients included in their study. A linear relationship between serum uric acid and systolic blood pressure was found by them.…”

Section: Introductionmentioning

confidence: 99%

Study of uric acid and lipid profile in recent onset essential hypertension

2020

IJCBR

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Introduction: Hypertension is a major public health problem. Uric acid is emerging as one of the strongest risk factors for hypertension. Alteration in lipid profile has been identified as independent risk factor for hypertension. Aim: The aim of our present study was to determine the association of uric acid and lipid profile with hypertension of recent onset. Materials and Methods: 45 subjects with age group between 20-50 yrs with recent onset essential hypertension were taken as test group. Control group comprised of 45 healthy, age and sex matched controls satisfying the exclusion criteria. Serum Uric acid, TC, HDL-C,LDL-C, TG'S were determined by enzymatic methods using commercially available kits on a fully automated analyzer. VLDL was a calculated parameter. Results: In the test group the mean uric acid levels in males and females were 6.1 ± 0.78 mg/dl and 5.5 ± 0.93 mg/dl respectively. The mean uric acid levels among males and females in the control population was 4.2 ± 0.81 and 4.1± 0.56 mg/dl respectively. A significant difference in uric acid levels between the test group and control group both among males (p= 0.039) and females (p= 0.041) was observed. Among the lipid profile parameters. The mean Total cholesterol and Triglycerides were high in cases as compared to controls with p-values of 0.046 and 0.038 respectively. In test group higher mean values for HDL-C, LDL-C, VLDL were found as compared to controls but the increase was not statistically significant. Conclusion: A significant association of UA with Hypertension both among males and females was observed in our study. Among the lipid profile parameters a significant association was found between Total cholesterol, Triglycerides and hypertension.

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Serum uric acid levels in hypertensive patients with and without metabolic syndrome in the hills of Himachal Pradesh, India

Cited by 2 publications

References 3 publications

Study of Serum Uric Acid Level in Patients with SystemicEssential Hypertension in the Context of New 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline

Study of Serum Uric Acid Level in Patients with SystemicEssential Hypertension in the Context of New 2017 ACC/AHA High Blood Pressure Clinical Practice Guideline

Study of uric acid and lipid profile in recent onset essential hypertension

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