Serum uric acid levels in patients with oral cancer, leukoplakia and submucous fibrosis: a cross-sectional study

Yadav, Karthik D; Patil, Bharati; Raheel, Syed Ahmed; Abuderman, Abdulwahab; Patil, Shankargouda; Gaballah, Kamis; Kujan, Omar

doi:10.21037/tcr.2020.01.08

Cited by 11 publications

(11 citation statements)

References 27 publications

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“…It is well-established that chewing areca nut (Areca catechu) is the major causative factor of OSF (IARC, 2004). Areca nut increases cells' oxidative stress that leads to DNA damage (Yadav et al, 2020). The disruption of cyclin-dependent kinases has also been postulated in oral carcinogenesis (Kujan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis

2020

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Objectives: This systematic review and meta-analysis aimed to determine the proportion of patients who develop oral carcinomas following a diagnosis of oral submucous fibrosis (OSF) in reported longitudinal studies. We also aimed to evaluate the demographic and clinicopathological factors contributing to the progression of OSF to cancer.Methods: Individual search strategies were applied for the following bibliographic databases: MEDLINE by PubMed, Scopus, Embase, Web of Science, and Grey literature databases until August 30, 2020. Methodological assessment of the risk of bias of the included studies was undertaken using the modified Newcastle-Ottawa scale.Meta-analyses were conducted using a random-effects (DerSimonian and Liard) method to calculate the pooled proportion of the malignant transformation (MT) in OSF patients.Results: Out of 585 records screened, a total of 9 observational studies were included with a total number of 6,337 patients; of these, 292 OSF cases developed carcinomas. The pooled proportion of the MT was 4.2% (95% CI: 2.7%-5.6%) with an annual transformation rate of 0.73%. Subgroup analysis revealed that the pooled MT proportion was significantly higher among population-based studies in comparison with hospital-based ones (p < .005). Most of the studies showed a high risk of bias. In several studies, there was a lack of information about the demographic and clinicopathological characteristics of OSF patients and associated risk indicators; this insufficiency in details hindered the ability to conduct further subgroup analyses.Conclusions: Despite the poorly reported and the limited number of studies, our analysis confirms that close to 4% of patients diagnosed with OSF may develop oral cancer. Cases with oral epithelial dysplasia had a higher potential for malignant transformation.

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Section: Discussionmentioning

confidence: 99%

Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis

2020

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“…In a study conducted by Yadav et al based on the assessment of serum uric acid in leukoplakia, submucous fibrosis, and squamous cell carcinoma, it was concluded that serum uric acid levels were reduced in patients with oral leukoplakia (OL) and OSCC, but they were increased in patients with oral submucous fibrosis (OSMF) when compared with the healthy control [ 29 ]. Given the linear association between serum and salivary uric acid, further studies might be carried out to associate salivary uric acid levels with premalignant and malignant conditions of the oral cavity.…”

Section: Reviewmentioning

confidence: 99%

Salivary Uric Acid: A Noninvasive Wonder for Clinicians?

Jaiswal¹,

Madaan²,

Acharya³

et al. 2021

Cureus

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This review is a summary of the modern-day approach and recent trend in the determination of uric acid in the saliva of humans and its use in diagnosis by clinicians. Uric acid, which is the end product obtained from the breakdown of purine nucleotides, is an important biomarker associated with various conditions. Uric acid is found in various body fluids, such as serum, plasma, and urine. It can be used as an important tool for various diseases, such as gout and hyperuricemia, or conditions that are associated with increased oxidative stress. Recently, there has been an emergence of studies that have utilized uric acid concentrations measured in the saliva and studied its association with various diseases. Salivary uric acid can prove to be a noninvasive method to provide a diagnosis of serious illness. A raised uric acid level in the saliva can be associated with cancer, human immunodeficiency virus (HIV) infection, gout, and hypertension. A reduced level of salivary uric acid on the other hand can be a marker for Alzheimer’s disease, progression of multiple sclerosis, and impairment of cognition. Online search databases, including Google Scholar, Scopus, PubMed, and Web of Science, were searched, and articles that were published before September 2021 based on salivary uric acid analysis were analyzed for this review. Uric acid is an essential biomarker that has antioxidant properties. Assessment of salivary uric acid levels was found to be essential in conditions such as cancer, metabolic syndrome, neurological conditions, psychiatric conditions, human immunodeficiency virus, and gout and in monitoring treatment of hyperuricemia. Although having importance in diagnosis and therapeutic monitoring, salivary uric acid analysis has not gained enough popularity due to limitations such as saliva collection and sample processing issues. With proper education and standardization, salivary uric acid analysis can be used as a cost-effective and noninvasive tool for getting a clue about antioxidant biomarker concentration in saliva and hence various diseases associated with oxidative stress.

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“…Hyperuricemia is an important and independent risk factor for cardiovascular disease and cardiovascular risk factors, such as hypertension, hyperlipidemia, type 2 diabetes, obesity, insulin resistance, and metabolic syndrome [ 6 ]. Many studies have shown that the increase of SUA level is an independent risk factor for malignant tumor occurrence and poor prognosis [ 7 , 8 ]. The proinflammatory properties of SUA may play an important role in the occurrence and development of cancer [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation

Zhang

Tang

et al. 2022

Journal of Healthcare Engineering

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Aiming to explore the correlation between preoperative serum oxidative stress level and serum uric acid and prognosis of hepatitis B-related liver cancer, the clinical data of 712 patients with hepatitis B-related liver cancer from January 2019 to December 2020 were retrospectively analyzed. By using the receiver operating curve, the optimal critical values of preoperative superoxide dismutase (SOD), malondialdehyde (MDA), and serum uric acid (SUA) are determined. The single-factor and multifactor Cox models are applied to screen out the suspicious factors affecting the prognosis of patients with hepatitis B-related liver cancer. According to the survival status of patients, the optimal thresholds of SOD, MDA, and SUA before operation were 58.055/mL, 10.825 nmol/L, and 312.77 nmol/L, respectively. The results of univariate analysis show that the prognosis of patients is significantly correlated with preoperative SOD, MDA, and SUA levels and TNM staging P < 0.05 . Additionally, multivariate analysis demonstrates that preoperative SOD < 58.055 U/mL and SUA ≥ 312.770 mmol/L and TNM stage III-IV are independent risk factors for postoperative prognosis P < 0.05 . Our study suggests that SOD, SUA, and TNM staging have certain value in judging the early prognosis of patients with hepatitis B-related liver cancer. Patients with high preoperative SOD level and low preoperative SUA level can obtain better prognosis.

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Serum uric acid levels in patients with oral cancer, leukoplakia and submucous fibrosis: a cross-sectional study

Cited by 11 publications

References 27 publications

Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis

Malignant transformation of oral submucous fibrosis: A systematic review and meta‐analysis

Salivary Uric Acid: A Noninvasive Wonder for Clinicians?

Correlation between Serum Oxidative Stress Level and Serum Uric Acid and Prognosis in Patients with Hepatitis B-Related Liver Cancer before Operation

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