Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome

Denzer, Christian; Muche, Rainer; Mayer, Hermann; Heinze, E.; Debatin, Klaus‐Michael; Wabitsch, Martin

doi:10.1515/jpem.2003.16.9.1225

Cited by 48 publications

(33 citation statements)

References 21 publications

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“…However, when all components of the MS were simultaneously included in the analysis, UA values remained significantly associated with BMI-SDS, with systolic BP, and with HOMA-IR, after adjustment for age, sex, Tanner stage, and creatinine. The strong association in our obese children between UA and BMI-SDS confirm previous studies reporting significant associations between UA concentrations and various anthropometric measures in children and adolescents (14,16). Yet, our finding of a strong association of UA with systolic BP is consistent with a growing literature on the possible role of UA in the pathogenesis of childhood primary hypertension (34)(35)(36).…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have shown a close relation between hyperuricemia and the MS both in adults and children (9,11,14,16,21,32,33). The prevalence of the MS among our obese children in the lowest quartile of concentrations of UA was very low (4.6%), while a high percentage (41.6%) of the children in the highest quartile of concentrations of UA had the MS.…”

Section: Discussionmentioning

confidence: 42%

“…impaired glucose tolerance, insulin resistance, or multiple MS, hypertension, dyslipidemia, obesity, and central adiposity (16,21,33)). In the study by Ford et al abdominal obesity, hypertriglyceridemia, and hyperglycemia remained significantly associated with concentrations of UA even after adjustment for age, sex, race or ethnicity, concentrations of C-reactive protein, and other components of the MS (14).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children

Pacifico¹,

Cantisani²,

Anania³

et al. 2009

European Journal of Endocrinology

123

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Objective: The association between hyperuricemia, metabolic syndrome (MS), and atherosclerotic vascular disease has been reported in adults, but very little is known about this association in children. The aims of our study were to ascertain the correlates of uric acid (UA) in a sample of obese children, and to investigate whether UA is associated with carotid intima-media thickness (IMT) independently from classical risk factors including MS. Methods: We analyzed carotid IMT along with serum triglycerides, total and high-density lipoprotein cholesterol, glucose, insulin, insulin resistance index (as homeostasis model assessment of insulin resistance), alanine aminotransferase, g-glutamyltransferase, creatinine, and UA in 120 obese children and 50 healthy control children. Results: UA concentrations were significantly higher in obese children compared with controls; moreover, they correlated with the most established cardiovascular risk factors. In the group of obese children, after adjustment for age, sex, pubertal stage, and creatinine, an independent association between UA levels and the presence of MS syndrome was observed (unstandardized coefficient, 0.044 (95% confidence intervals (CI) 0.015-0.072); P!0.01). Carotid IMT significantly increased in the fourth quartile of UA compared with that in the first, second, and third quartile (0.49 (0.46-0.53), 0.53 (0.49-0.56), and 0.55 (0.52-0.59) vs 0.61 (95% CI, 0.58-0.64); P!0.01). When multivariate analysis was performed after adjusting for age, gender, pubertal stage, creatinine, and MS (considered as a single clinical entity), or the individual components of MS simultaneously included, the association between UA and carotid IMT was significant (P!0.01). Conclusions: In obese children and adolescents, increased UA levels are associated with carotid atherosclerosis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children

Pacifico¹,

Cantisani²,

Anania³

et al. 2009

European Journal of Endocrinology

123

View full text Add to dashboard Cite

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“…Animal studies showed that castration of male rats decreased synthesis of nucleotides, guanosine monophosphate, and adenosine monophosphate and nucleotide catabolism, which was restored by administration of testosterone. 55,56 In a sample of obese children aged 10 to 16 years, Denzer et al 57 reported a significant positive association between plasma testosterone and uric acid concentrations. Furthermore, animal studies have demonstrated gender differences in uric acid transporters, such as urate transporter 1 and organic anion transport.…”

Section: Discussionmentioning

confidence: 99%

Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women

et al. 2007

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Abstract-Fructose-induced hyperuricemia might have a causal role in metabolic syndrome, hypertension, and other chronic disease. However, no study has investigated whether sugar added to foods or sugar-sweetened beverages, which are major sources of fructose, are associated with serum uric acid concentration in free-living populations. We examined the relationship between the intakes of added sugars and sugar-sweetened beverages and serum uric acid concentrations in the National Health and Nutrition Examination Survey 2001-2002, a nationally representative sample of men and women. We included 4073 subjects (1988 men and 2085 women) Ͼ18 years of age in the current study. Dietary intake was assessed by a single 24-hour recall. We used multivariate linear regression to adjust for age, gender, intake of energy and alcohol, body mass index, use of diuretics, ␤-blockers, and other covariates. Male subjects in the highest intake quartile of estimated intake of added sugars or sugar-sweetened drinks had higher plasma uric acid concentrations than those in the lowest intake quartiles (PϽ0.001 for both) after adjusting for potential confounders, whereas we did not observe significant associations for females (P for trendϾ0.2; P for interaction Ͻ0.01). Further research is needed to confirm causality of these associations and the observed difference by gender. (Hypertension. 2007;50:306-312.)

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“…Hyperuricemia is mostly associated with primary metabolic disorders of purine metabolism or tumor lysis syndrome. In addition, several reports have shown a correlation between plasma uric acid concentration and body mass index (BMI) in adolescents [7,8].…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia and gout following pediatric renal transplantation

2006

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Hyperuricemia and gout are common complications in adult renal transplant recipients. In pediatric recipients, however, hyperuricemia seems to be rare, but data are scarce. Thirty-two children (21 males, 11 females) were investigated for a median time of 4.8 years (range: 0.4-11.2 years) following renal transplantation. The median age of this pediatric study group was 13.9 years (range: 5.7-20.3 years), and the calculated glomerular filtration rate (GFR) was 61 ml/min per 1.73 m(2) (range:12-88 ml/min per 1.73 m(2)). All patients were given calcineurin inhibitors, with 22 and ten children receiving cyclosporine A (CSA) and tacrolimus (TAC), respectively. The median plasma uric acid was 385 micromol/l (range: 62-929 micromol/l); 15 children (47%) were above the age-related normal range. Only one patient experienced gouty arthritis. There was a significant correlation between plasma uric acid concentration and both time span after transplantation and plasma creatinine, and an inverse correlation to GFR (p<0.05). No significant correlation was found between plasma uric acid and body mass index (BMI). Plasma uric acid concentrations were neither different among CSA- and TAC-treated children, nor did they correlate with drug exposure or blood trough levels of CSA or TAC. Plasma uric acid concentration was not different when compared to children with chronic renal failure (CRF) of a similar degree in native kidneys. We conclude that hyperuricemia is common among pediatric renal transplant recipients and rather a consequence of chronic renal transplant dysfunction than the use of calcineurin inhibitors. Gout, however, is rare.

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Serum Uric Acid Levels in Obese Children and Adolescents: Linkage to Testosterone Levels and Pre-metabolic Syndrome

Cited by 48 publications

References 21 publications

Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children

Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children

Intake of Added Sugar and Sugar-Sweetened Drink and Serum Uric Acid Concentration in US Men and Women

Hyperuricemia and gout following pediatric renal transplantation

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