Serum Uric Acid Predicts Both Current and Future Components of the Metabolic Syndrome

Osgood, Kristy; Krakoff, Jonathan; Thearle, Marie S.

doi:10.1089/met.2012.0151

Cited by 59 publications

(39 citation statements)

References 29 publications

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“…Osgood and colleagues proposed that the serum uric acid not only correlates with concomitant insulin action, blood pressure, and lipid profile; it also predicts future insulin resistance and type 2 diabetes. 23 • In our study ADA levels were statistically significantly increased (p<0.0001) in Obese compared to controls. ADA regulates intracellular and extra cellular concentrations of adenosine 24 .…”

Section: IIIsupporting

confidence: 52%

Association of Serum Uric Acid and ADA Levels in an Obese With or Without Metabolic Syndrome

Prasad¹,

Venkataramana²

2017

IOSR JDMS

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Section: IIIsupporting

confidence: 52%

Association of Serum Uric Acid and ADA Levels in an Obese With or Without Metabolic Syndrome

Prasad¹,

Venkataramana²

2017

IOSR JDMS

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“…According to previous studies, hyperinsulinemia could activate uric acid transporters and increase reabsorption of sodium and potassium in hypertensive subjects [24]. Moreover, hyperinsulinemia increases intracellular pH and activates the renal tubular Na⁺-H⁺ exchange, followed by reabsorption of anions and urate salts [25,26]. However, in the present study, insulin resistance was not incorporated into the analysis due to absence of laboratory indicators reflecting insulin resistance, and further clinical and experiment studies should be done.…”

Section: Fig 2 Differences In 24-h Uur Cur and Feur According To Tementioning

confidence: 87%

The Association of Urinary Sodium and Potassium with Renal Uric Acid Excretion in Patients with Chronic Kidney Disease

Guo

Zou

et al. 2018

Kidney Blood Press Res

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Background/Aims: Hypertension and hyperuricemia are closely associated with an intermingled cause and effect relationship. Additionally, urinary sodium and potassium excretion is related to blood pressure. Whether or not it is associated with urinary uric acid excretion is not clear. Therefore, we aim to study the association of urinary sodium and potassium with renal uric acid excretion in patients with CKD. Methods: A cross-sectional study of 428 patients with CKD recruited from our department was conducted. All patients were divided into hypertension and non-hypertension group. In these two groups, Spearman correlation and multiple linear regression analysis were used to study the correlation of urinary sodium and potassium with renal handling of uric acid. Results: According to multiple linear regression analysis, in hypertension group, fractional excretion of sodium (FEna) was negatively correlated with 24 hour urinary uric acid (24-hUur) and uric acid clearance rate (Cur) (beta coefficients [B]=-0.066, -0.182, respectively; both P< 0.05), and positively correlated with fractional excretion of uric acid (FEur) (B=1.641, P< 0.001). Additionally, fractional excretion of potassium (FEk) was positively correlated with FEur (B=0.576, P< 0.001), but not related to 24-hUur and Cur (both P>0.05). And urinary sodium/potassium ratio (Una/k) was negatively related to 24-h Uur and Cur (B=-0.047, -0.159, both P< 0.05), and positively related to FEur (B=0.578, P< 0.05). Furthermore, FEna and FEk was still positively related to FEur in the lowest tertile of eGFR groups (both P< 0.05), but not related in the second and highest tertile of eGFR groups (all P> 0.05). In non-hypertension group, FEna was negatively correlated with 24-hUur (B=-0.589, P< 0.05), but not related to Cur and FEur (both P> 0.05). both FEk and Una/k was not related to 24-h Uur, Cur and FEur (all P> 0.05). Moreover, FEna and FEk was still not correlated with FEur in all tertiles of eGFR groups (all P> 0.05). Conclusion: We found that in patients with CKD, urinary sodium and potassium excretion is closely correlated to renal handling of uric acid, which was pronounced in hypertensive patients with low eGFR. This phenomenon may be one of the mechanisms of the relationship between hypertension and hyperuricemia. Further research is needed to confirm it. It is expected to manage hyperuricemia in terms of controlling the diet of sodium and potassium.

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“…Conversely, two studies with large populations failed to demonstrate a significant relationship between SUA and LVH in patients with essential HT and untreated HT 23)24). SUA is usually associated with multiple risk factors, including HT, obesity, dyslipidemia, and insulin resistance, all of which are also related to LVH 25). Thus, even if SUA may not be related to LVH in the general population, this association may become evident in selected populations, like in our study, that mainly includes patients with metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Bilirubin Level is Associated with Left Ventricular Hypertrophy Independent of Blood Pressure in Previously Untreated Hypertensive Patients

et al. 2014

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Background and ObjectivesLeft ventricular hypertrophy (LVH), a sign of subclinical cardiovascular disease, is an important predictor of cardiovascular morbidity and mortality. The aim of our study was to determine the association of left ventricular mass (LVM) with possible causative anthropometric and biochemical parameters as well as carotid intima-media thickness (CIMT) and brachial flow-mediated dilation (FMD) as surrogates of atherosclerosis and endothelial dysfunction, respectively, in previously untreated hypertensive patients.Subjects and MethodsOur study included 114 consecutive previously untreated hypertensive patients who underwent echocardiography and ultrasonography to evaluate their vascular status and function via brachial artery CIMT and FMD.ResultsAmong all study parameters, age, systolic blood pressure (BP), diastolic BP, pulse pressure, plasma glucose, uric acid, total bilirubin, direct bilirubin, hemoglobin, and CIMT were positively correlated with the LVM index. Multiple logistic regression analysis revealed that office systolic BP, age, male gender, and total bilirubin were independent predictors of LVH.ConclusionBilirubin seems to be related to LVM and LVH. The positive association of bilirubin with these parameters is novel and requires further research.

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Serum Uric Acid Predicts Both Current and Future Components of the Metabolic Syndrome

Cited by 59 publications

References 29 publications

Association of Serum Uric Acid and ADA Levels in an Obese With or Without Metabolic Syndrome

Association of Serum Uric Acid and ADA Levels in an Obese With or Without Metabolic Syndrome

The Association of Urinary Sodium and Potassium with Renal Uric Acid Excretion in Patients with Chronic Kidney Disease

Bilirubin Level is Associated with Left Ventricular Hypertrophy Independent of Blood Pressure in Previously Untreated Hypertensive Patients

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