Serum Uric Acid to Creatinine Ratio Independently Predicts Incident Metabolic Syndrome Among Community-Dwelling Persons

Kawamoto, Ryuichi; Ninomiya, Daisuke; Akase, Tomoko; Kikuchi, Asuka; Kasai, Yoshio; Kusunoki, Tomo; Ohtsuka, Nobuyuki; Kumagi, Teru

doi:10.1089/met.2018.0055

Cited by 18 publications

(21 citation statements)

References 37 publications

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“…Thus, the renal function-normalized SUA (SUA to creatinine ratio, abbreviated SUA/Scr) might be more predictive than SUA alone in such studies. As expected, SUA/Scr is truly more sensitive than SUA in relation to Parkinson's disease, metabolic syndrome (MetS), liver function, nonalcoholic fatty liver disease (NAFLD) and chronic obstructive pulmonary disease (COPD) [14][15][16][17][18][19][20][21]. Our previous study also found that SUA/Scr could predict renal disease progression (incident CKD and ESRD) and correlate with β-cell function among type 2 diabetes patients [22][23][24].…”

Section: Introductionsupporting

confidence: 60%

The Association Between the Serum Uric Acid to Creatinine Ratio and All-Cause Mortality in Elderly Hemodialysis Patients

Ding¹,

Yao

Chun-lei³

et al. 2022

Preprint

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Purpose: The present study investigated the association between the serum uric acid to creatinine ratio (SUA/Scr) and all-cause mortality among elderly hemodialysis patients.Methods: A total of 222 patients (≥ 60 years) who received hemodialysis more than 8 hours per week at Tai Zhou No. 2 People’s Hospital for at least 3 months were enrolled in the present study from January 2015 to December 2019. Clinical characteristics were obtained from the hemodialysis database, and survival information was recorded during the follow-up period. Multiple Cox regression was carried out to analyze the association between SUA/Scr and all-cause mortality. The survival rate of each group was calculated by the Kaplan-Meier method, and the ratio of survival curves was analyzed by the log-rank test.Results: During the 19-month observation period, 78 patients died. Individuals in the nonsurviving group had significantly older ages (P<0.001), body mass index (BMI) (P=0.004), serum creatinine (P=0.005) and prealbumin (P=0.006) than surviving patients. After adjusting for age, sex, BMI, prealbumin and serum creatinine, a higher ratio of SUA/Scr was independently associated with a higher risk of all-cause mortality (HR: 1.375; 95% CI: 1.023-1.848; P=0.035).Conclusion: The serum uric acid to creatinine ratio is strongly associated with all-cause mortality in elderly hemodialysis patients.

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Section: Introductionsupporting

confidence: 60%

The Association Between the Serum Uric Acid to Creatinine Ratio and All-Cause Mortality in Elderly Hemodialysis Patients

Ding¹,

Yao

Chun-lei³

et al. 2022

Preprint

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show abstract

“… 38 , 39 Other evidence indicates that SUA may have a pathogenic role through vascular effects. 40 Additionally, SUA/SCr is associated with many cardiometabolic factors 14 , 15 , 16 that may provide a mediating pathway for the association between SUA/SCr and CVD.…”

Section: Discussionmentioning

confidence: 99%

“… 9 , 10 , 11 , 12 , 13 However, evidence on the effect of SUA/SCr on CVD is limited and, to date, the potential pathway linking SUA/SCr to CVD remains incompletely characterized. SUA/SCr was confirmed to be associated with various cardiometabolic factors, 9 , 14 , 15 , 16 , 17 , 18 which raised the question as to whether SUA/SCr can lead directly to the outcome of CVD, or if cardiometabolic factors, such as indicators of obesity, blood glucose, blood lipids, blood pressure, and indicators of inflammation play potentially mediating roles in the association between SUA/SCr and CVD.…”

mentioning

confidence: 99%

Metabolic Factors Mediate the Association Between Serum Uric Acid to Serum Creatinine Ratio and Cardiovascular Disease

Wang

Tian

Zuo

et al. 2021

JAHA

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Background The serum uric acid/serum creatinine ratio (SUA/SCr), which represents renal function‐normalized SUA, is associated with diverse adverse outcomes. The aim of this study was to investigate the association between SUA/SCr and cardiovascular disease (CVD), and determine whether and to what extent this association is mediated by cardiometabolic factors. Methods and Results This prospective study enrolled 96 378 participants from the Kailuan study without stroke and myocardial infarction at baseline (2006). Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Mediation analyses were conducted to separately explore the mediating effects of cardiometabolic factors on the association between SUA/SCr and CVD. During median follow up of 11.01 years, 6315 (6.55%) individuals developed incident CVD. After adjustment for potential confounders, the highest quartile of SUA/SCr was associated with the highest risk of CVD (HR, 1.15; 95% CI, 1.07–1.23), stroke (HR, 1.16; 95% CI, 1.07–1.26), ischemic stroke (HR, 1.12; 95% CI, 1.02–1.22), and hemorrhagic stroke (HR, 1.36; 95% CI, 1.11–1.65), but not with myocardial infarction (HR, 1.07; 95% CI, 0.92–1.25). The association was consistent across different degrees of kidney function and glucose tolerance statuses. Additionally, the association between high SUA/SCr and CVD was partially mediated by triglycerides (30.74%), body mass index (BMI) (19.52%), total cholesterol (15.06%), hs‐CRP (high‐sensitivity C‐reactive protein) (13.06%), diastolic blood pressure (11.75%), and blood glucose (−16.38%). Conclusions SUA/SCr and CVD were positively associated. Furthermore, this association was partially mediated through blood lipids, BMI, blood pressure, hs‐CRP, and blood glucose.

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“…40 The retrospective cohort study in Japanese women proved that SUA/creatinine ratio was associated with incident MetS. 41 Hyperuricemia is considered to be a RF for CVDs. 42 The meta-analysis of prospective cohort studies showed that hyperuricemia slightly increases the risk for CVD and total mortality rate, more in women.…”

Section: Discussionmentioning

confidence: 99%

Associations of Serum Uric Acid with Endogenous Cholesterol Synthesis Indices in Men with High Cardiometabolic Risk

Vecka

Žák

Tvrzická

et al. 2020

Metabolic Syndrome and Related Disorders

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Background: Patients with metabolic syndrome (MetS) have increased endogenous synthesis of cholesterol, together with lower level of intestinal cholesterol absorption. However, less is known about how individual metabolic disturbances linked to MetS correlate with dysregulated cholesterol homeostasis. Methods: We consecutively examined 178 probands (91 women/87 men) characterized by the presence of one or two components of MetS (group with an increased cardiometabolic risk [CMR]) and 42 healthy controls (24 men/18 women) of similar age, as well. In all probands, the surrogate markers for cholesterol biosynthesis (lathosterol) and absorption (campesterol and b-sitosterol) were measured by capillary gas chromatography. In CMR group, we performed multivariate regression analysis to assess the dependence of the parameters of cholesterol biosynthesis/absorption on components of MetS including serum uric acid (SUA), apolipoprotein B (apoB), and age. Results: In CMR group, higher lathosterol to total plasma cholesterol (TC) ratio (LCR) was influenced by gender (P = 0.05, analysis of covariance [ANCOVA] for age), whereas ratios of campesterol (b-sitosterol, respectively) to TC were lower in CMR group (P < 0.001 and P = 0.002, ANCOVA for age). In men, LCR was positively associated with SUA, apoB, and hypertension (all P < 0.05). Lathosterol to campesterol or bsitosterol ratios were highly dependent on SUA (both P < 0.01), the former being dependent also on apoB (P < 0.01). In women, these parameters were only weakly dependent on SUA. Conclusions: These results show that the concentration of SUA in men of CMR group is associated with the indices of de novo cholesterol biosynthesis. This association is probably influenced by interaction of arterial hypertension and apoB levels with cholesterol homeostasis.

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Serum Uric Acid to Creatinine Ratio Independently Predicts Incident Metabolic Syndrome Among Community-Dwelling Persons

Cited by 18 publications

References 37 publications

The Association Between the Serum Uric Acid to Creatinine Ratio and All-Cause Mortality in Elderly Hemodialysis Patients

The Association Between the Serum Uric Acid to Creatinine Ratio and All-Cause Mortality in Elderly Hemodialysis Patients

Metabolic Factors Mediate the Association Between Serum Uric Acid to Serum Creatinine Ratio and Cardiovascular Disease

Associations of Serum Uric Acid with Endogenous Cholesterol Synthesis Indices in Men with High Cardiometabolic Risk

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