Serum Urokinase-Type Plasminogen Activator Receptor Does Not Outperform C-Reactive Protein and Procalcitonin as an Early Marker of Severity of Acute Pancreatitis

Kolber, Witold; Kuśnierz-Cabała, Beata; Dumnicka, Paulina; Maraj, Małgorzata; Mazur-Laskowska, Małgorzata; Pędziwiatr, Michał; Ceranowicz, Piotr

doi:10.3390/jcm7100305

Cited by 27 publications

(51 citation statements)

References 37 publications

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“…In our study acute pancreatitis was more commonly seen in men associated with alcoholism, followed by gall stones in females, similar to a study conducted at IPGMER, Kolkata Eastern India from January 2014 to January 2017 in 234 patients. 26 Procalcitonin in our study was found to be high in patients of severe acute pancreatitis and the same observation were made at two different study done at Poland by Kolber et al 27 and at Finland by Back et al 28 receptively.…”

Section: R E S U L T Ssupporting

confidence: 88%

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Kaur¹,

Singh²

2020

jebmh

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BACKGROUND Acute Pancreatitis is usually a mild disease with minimal organ dysfunction. Sometime it can have severe complications and high mortality despite treatment. There is a need to identify patients at risk for complications so as to provide an early effective management. Procalcitonin, an inflammatory biomarker increases in acute pancreatitis with complications. So, we studied procalcitonin serum levels in acute pancreatitis patients to see if it can be used as an early predictor of development of complications. METHODS This was a prospective observational study, carried out at our tertiary care teaching hospital, north INDIA. A total of 60 cases were included in this study as per the inclusion criteria. Serum procalcitonin of ≥0.5 ng/ml was taken as significant. RESULTS Serum procalcitonin (PCT) was found to be non-significant in 61.6% (37 out of 60) patients, out of these, none had any complication, antibiotics use, low CT Severity Index (CTSI) score, early recovery and no death. Serum procalcitonin (PCT) was significant in 38.3% (23 out of 60) patients. CTSI score (>5) in 19 of these patients. Hypotension and respiratory failure were seen in 20 and 21 patients respectively with a significant p value of 0.001. Antibiotic use was observed in all the 23 patients in this group (p value 0.05). Duration of hospital stay was longer (more than mean 7.08±4.018 days) with significant p value of 0.005. Four participants died due to the complications related to acute severe pancreatitis. Mean value of PCT in participants who died was 4.2 ± 3.47 ng/ml with p value of 0.005 CONCLUSIONS Serum procalcitonin level in acute pancreatitis had good correlation with development of complications of cardiovascular, respiratory system, high CT score, and longer duration of hospital stay, antibiotic use and death. Hence procalcitonin can be used to predict complication at an early stage of acute pancreatitis.

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Section: R E S U L T Ssupporting

confidence: 88%

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Kaur¹,

Singh²

2020

jebmh

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“…At present, no single laboratory marker can be recommended for the early prediction of the development of OF in AP. Recent studies showed that angiopoietin-2(a marker of vascular leak syndrome) [30] or serum urokinase-type plasminogen activator receptor (uPAR) [31] can be applied as a marker in predicting persistent organ failure. Unfortunately, the detections of these indicators are not widely used so far and is difficult to obtain in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Xie

Dong

et al. 2020

BMC Gastroenterol

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Background: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP). Methods: We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBA max. Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBA max was ≥10 μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the two groups. Logistic regression analysis and receiving operating characteristic (ROC) curve were used to evaluate the relationship between circulating TBA and organ failure in AP patients. Results: Through stratified analysis of each time period, we found that the incidence of OF in the HTBA group was significantly higher than that in the NTBA group, and the AP severity classification in the HTBA group was more serious than that in the NTBA group. In addition, according to the D7 TBA max values, the pancreatic necrosis rate, percutaneous catheter drainage (PCD) rate and mortality in the HTBA group were higher than those in the NTBA group. Multivariate regression analysis showed that HTBA (odds ratio (OR), 4.894; P = 0.002) was an independent risk factor for AP complicated with OF, which was verified in the grouping based on D7 TBA max. ROC analysis revealed that a circulating D7 TBA max cutoff point of 6.450 umol/L had optimal predictive value for the development of OF in AP patients with an area under the curve of the ROC curve (AUCROC) of 0.777. Conclusions: The increase of circulating TBA in early stage of AP is independently related to organ failure, which indicates the adverse prognosis of AP patients.

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“…Recent studies showed that angiopoietin-2(a marker of vascular leak syndrome) [30] or serum urokinase-type plasminogen activator receptor (uPAR) [31] can be applied as a marker in predicting persistent organ failure. Unfortunately, the detections of these indicators are not widely used so far and is difficult to obtain in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Xie

et al. 2020

Preprint

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Background: Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with the severity of acute pancreatitis (AP).Methods: We retrospectively collected data on patients diagnosed with AP in a tertiary center from 01 January 2014 to 31 December 2016. The highest TBA value during the first 1,2,3,5,7 days after admission was determined as D1, D2, D3, D5, D7 TBAmax. Patients were divided into the high TBA (HTBA) group and the normal TBA (NTBA) group according to whether the TBAmax was ≥10μmol/L. The prognosis and complications, including death, organ failure (OF) and pancreatic necrosis, were compared between the two groups. Logistic regression analysis and receiving operating characteristic (ROC) curve were used to evaluate the relationship between circulating TBA and organ failure in AP patients.Results: Through stratified analysis of each time period, we found that the incidence of OF in the HTBA group was significantly higher than that in the NTBA group, and the AP severity classification in the HTBA group was more serious than that in the NTBA group. In addition, according to the D7 TBAmax values, the pancreatic necrosis rate, percutaneous catheter drainage (PCD) rate and mortality in the HTBA group were higher than those in the NTBA group. Multivariate regression analysis showed that HTBA (odds ratio (OR), 4.894; P = 0.002) was an independent risk factor for AP complicated with OF, which was verified in the grouping based on D7 TBAmax. ROC analysis revealed that a circulating D7 TBAmax cutoff point of 6.450 umol/L had optimal predictive value for the development of OF in AP patients with an area under the curve of the ROC curve (AUCROC) of 0.777. Conclusions: The increase of circulating TBA in early stage of AP is independently related to organ failure, which indicates the adverse prognosis of AP patients.

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Serum Urokinase-Type Plasminogen Activator Receptor Does Not Outperform C-Reactive Protein and Procalcitonin as an Early Marker of Severity of Acute Pancreatitis

Cited by 27 publications

References 37 publications

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Evaluation of Procalcitonin as an Early Prognostic Marker in Acute Pancreatitis

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

Increased circulating total bile acid levels were associated with organ failure in patients with acute pancreatitis

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