Serum Values of Cardiac Troponin-T in Normal and Cardiomyopathic Dogs

Tarducci, Alberto; Abate, O; Borgarelli, Michele; Borrelli, Antonio; Zanatta, Rayssa Ferreira; Cagnasso, Aurelio

doi:10.1023/b:verc.0000045451.89851.9d

Cited by 12 publications

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“…Ela também pode ser decorrente de outros mecanismos, como a resposta imunológica, incluindo a celular e humoral (Pascon et al 2010), com consequentes lesões miocárdicas tanto na fase aguda como crônica (Rossi & Mengel 1992). Nos cães que apresentaram valores de CK e CK-MB acima dos níveis normais pode sugerir lesão cardíaca (Souza et al 2008) e, apesar, da dosagem por quimioluminescência de cTnI, ser considerada mais sensível e especíϐica que a CK-MB, esta apresentou valores normais devido sua maior presteza em diagnóstico de lesões agudas que nas crônicas (Tarducci et al 2004). …”

Section: Animais Leuc (Ul) Ns (%) Ns (Abs) Nb (%) Nb (Abs) Eos (%) Eounclassified

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

et al. 2012

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This study aimed to evidence the clinical and laboratorial signs of this disease to help characterize this illness in a natural way in the semiarid in the northeastern region. We evaluated 10 positive for Trypanosoma cruzi dogs, that were identiϐied by serological analysis of immunoϐluorescence assay (RIFI) and enzyme linked immunosorbent assay (ELISA); molecular analysis by polymerase chain reaction (PCR), direct microscopy and blood culture. The chagasic dogs underwent physical examination, electrocardiographic, radiographic, blood pressure, hematology (erythrocyte and leukocyte count) and biochemical exams (urea, creatinine, ALT, AST, PT, albumin, globulin, CK, CK-MB, and cTnl). The physical examination and the blood pressure were presented within the normal range, while in the electrocardiography the FC was observed as normal with a sinus rhythm, with the exception of one dog that presented a sinus tachycardia (168 bat/min). In the ECG of eight dogs there was increase of duration of P (47+6.5ms) suggestive to atrial enlargement, not conϐirmed in the radiography. A supraunlevelling was observed in the ST segment in one dog. In the hematological results, thrombocytopenia (187.4x10 3 +137.2x10 3 ) and anemia (5.0x10 6 +1.39x10 6 /ul) were noted. The mean hemoglobin (11 +2.7g/dL), hematocrit (34+10.5%) were below normal limits. The white series were within normal variation, with the exception of eosinophilia observed in three dogs. Individually, there were two dogs which registered leukocytosis, lymphocytosis and neutrophilia. In the biochemical evaluation there was hyperproteinemia PT=7.2 +0.9g/dL, hypoalbuminemia (2.2+0.4g/dL), hyperglobulinemia (5.1+1.0g/dL), increased of CK (196+171 U/L) and there was no alteration on ALT and AST enzymes. The CK-MB isoenzymes and cTnI did not change, except in three dogs. We conclude that dogs naturally infected in the northeastern semiarid present characteristics related to indeterminate chronic form (asymptomatic dogs) and that the identiϐication of the naturally infected dogs with no pathognomonic characteristics of the Chagas disease underscores the importance of this illness in the diagnostic process with the other proϐiles that show nonspeciϐic or not associated to cardiovascular disease.INDEX TERMS: Heart disease, parasite, Trypanosoma cruzi, Chagas disease, diseases of dog, parasitology.

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Section: Animais Leuc (Ul) Ns (%) Ns (Abs) Nb (%) Nb (Abs) Eos (%) Eounclassified

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

et al. 2012

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“…6 Normal values for cardiac troponin I and T have been reported in veterinary species. [46][47][48][49][50][51][52][53] Although each assay must have its own range established, reports of normal values for healthy animals have correlated closely. 39 Most normal animals have cTn levels below the threshold of detection for current assays.…”

Section: Assaysmentioning

confidence: 99%

“…39 Most normal animals have cTn levels below the threshold of detection for current assays. [46][47][48][49][50][51][52][53] Normal cTnI ranges for dogs are reported at o0.03-0.07 ng/mL with a median of 0.02 ng/mL. 46 For cTnT all normal dogs had levels below the threshold for detection by the assay.…”

Section: Assaysmentioning

confidence: 99%

“…46 For cTnT all normal dogs had levels below the threshold for detection by the assay. 48,51 Cats have ranges of o0.03-0.16 ng/mL. 46 A report of normal levels in adult horses including pastured and race trained Thoroughbreds demonstrated a mean cTnI of 0.047 AE 0.085 ng/mL.…”

Section: Assaysmentioning

confidence: 99%

“…71 Several studies in veterinary medicine have shown that cTn levels can be elevated in primary heart diseases. [48][49][50][51][52] Hypertrophic cardiomyopathy (HCM) in cats can cause intramural coronary artery disease leading to microscopic areas of ischemia, and myocardial hypertrophy with cellular necrosis and cTn release into the circulation. 95,96 Although cats with mild HCM may have normal cTnI levels, a study has shown that cats with moderate to severe HCM with and without heart failure have significantly higher levels of circulating cTnI than normal cats.…”

Section: Primary Heart Disease and Heart Failurementioning

confidence: 99%

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Cardiac troponins

Wells

Sleeper

2008

J Vet Emergen Crit Care

111

118

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Objective: To review the use of cardiac troponins as biomarkers for myocardial injury in human and veterinary medicine. Data sources: Data sources included scientific reviews and original research publications. Human data synthesis: Cardiac troponins have been extensively studied in human medicine. Finding an elevated cardiac troponin level carries important diagnostic and prognostic information for humans with cardiovascular disease. Troponin assays are used primarily to diagnose acute myocardial infarction in patients with ischemic symptoms such as chest pain. However, elevated blood levels may be found with any cause of myocardial injury. Veterinary data synthesis: Several studies have shown that cardiac troponins are sensitive and specific for myocardial damage in veterinary patients and may have utility in diagnosis and prognosis for certain disease states. Human assays may be used in most animals due to significant homology in the troponin proteins between species. Conclusions: Cardiac troponins are sensitive and specific markers of myocardial injury although they do not give any information regarding the mechanism of injury. They have redefined how acute myocardial infarction is diagnosed in humans. Their use in the clinical management of veterinary patients is limited at this time. Further prospective studies are warranted.

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Cardiovascular Toxicology and Its Evaluation

Gad

2015

Mammalian Toxicology

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Serum Values of Cardiac Troponin-T in Normal and Cardiomyopathic Dogs

Cited by 12 publications

References 3 publications

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

Caracterização clínica e laboratorial de cães naturalmente infectados com Trypanosoma cruzi no semiárido nordestino

Cardiac troponins

Cardiovascular Toxicology and Its Evaluation

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