Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

Sun, Xiaomeng; Zhang, Heng; Liu, Jia; Wang, Guang

doi:10.1177/0300060519872033

Cited by 17 publications

(15 citation statements)

References 34 publications

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“…Moreover, there was no significant correlation between VEGF with age, gender, BMI, abdominal circumference, blood pressure, HbA1c, and other metabolic markers (cholesterol, LDL, and TG), p > 0.05. The detailed other research found no significant relationships between VEGF and sex, age, BMI, HbA1c, FBG, TG, TC, HDL-C, LDL-C, UA, or HCY [7]. Nevertheless, our study found a significant correlation between VEGF with FBS, HDL, and HIF-1α.…”

Section: Discussioncontrasting

confidence: 85%

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

Rusdiana

Widjaja

Amelia

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder whose prevalence continues to increase worldwide. Chronic hyperglycemia increases the area of hypoxia that can be measured by markers of hypoxia-inducible factor 1-alpha (HIF-1α) and endothelial cell damage by vascular endothelial growth factor (VEGF) secretion and the association of the course of diabetes mellitus, dyslipidemia is also a risk factor that can aggravate the condition. diabetes mellitus. AIM: The aim of this study was to correlate VEGF with HIF-1α and other metabolic markers in T2DM. METHODS: Examination such as blood pressure, height, and body mass index, and duration of diabetes were recorded. Laboratory examination like blood sugar levels and glycated hemoglobin (Hba1C) levels, lipid profile such as cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides were evaluated by Paramitha Laboratory Clinic and VEGF and HIF-1α we examined by ELISA methods in the Integrated laboratory of Medical Faculty, Universitas Sumatera Utara. The study was done by cross-sectional analytic methods, among 135 patients with T2DM who were admitted from the various primary health-care centers in Medan city and surrounding areas in North Sumatera. The inclusion criteria of the samples were all the patients diagnosed with T2DM, both the sexes, and the exclusion criteria of the samples with T1DM and severe disease. The data of the samples were processed using a computer with the SPSS program. RESULTS: There was a positive significant correlation between VEGF with HIF-1α, with a strong correlation, and found a negative correlation between VEGF with fasting blood sugar and HDL (p < 0.005). CONCLUSION: By finding strongly and positive correlation between VEGF and HIF-1α, the samples of menunjukkan bahwa peningkatan konsentrasi VEGF meningkat selaras dengan peningkatan konsentrasi dari HIF-1α _dan ini menunjukkan bahwa proses angiogenesis pada sample sedang berlangsung sebagai mekanisme kompensasi pertahanan vascular.

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Section: Discussioncontrasting

confidence: 85%

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

Rusdiana

Widjaja

Amelia

et al. 2021

Open Access Maced J Med Sci

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“…Like research by Martynova et al reported that high TGs were associated with high serum VEGF [14]. However, different research by Sun et al that there were no significant relationships between VEGF and any of the following factors such as sex, age, BMI, HbA1c, FBG, TG, TC, HDL-C, and LDL-C at type 2 DM [15]. In this study, we found that there was a significant and positive correlation between VEGF and BMI over a large range of BMI 17.63 kg/m 2 and 46.44 kg/m…”

Section: Discussionmentioning

confidence: 87%

The Correlation between Serum Vascular Endothelial Growth Factor and Lipid Profile in Type 2 Diabetes Mellitus

Rusdiana

Widjaja

Amelia

2020

Open Access Maced J Med Sci

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BACKGROUND: Diabetes mellitus is a chronic metabolic disease characterized by increased blood sugar levels (BSLs). Elevated BSL was to be reliably measured by measuring the concentration of hemoglobin glycosylate (HbA1C). Chronic hyperglycemia can result in damage to endothelial cells resulting in disruption of vascular hemostasis leading to complications in the form of vascular disorders. Endothelial damage or dysfunction will increase cytokines, one of which is vascular endothelial growth factor (VEGF), which induces angiogenesis. AIM: In our study we wanted to investigate the correlation between serums VEGF with lipid profile at type 2 diabetes mellitus patients in primary health care in Medan city of North Sumatera, Indonesia. MATERIALS AND METHODS: This study conducted at type 2 diabetes mellitus with the cross-sectional analytic method. The inclusion criteria of the samples were all the patients diagnosed with type 2 diabetes mellitus, both the sexes. Body mass index (BMI), blood pressure, duration of disease, and family history were recorded. The laboratory parameters, including fasting blood sugar, HbA1c, high-density lipoprotein, low-density lipoprotein, triglycerides (TG), and cholesterol, were examined by Paramita Laboratory Clinic and VEGF and hypoxia-inducible factor (HIF)-1α, we examined by ELISA methods in the laboratory Medical Faculty, Universitas Sumatera Utara. The data of the samples were processed using a computer with the SPSS program. RESULTS: There was a significant correlation between VEGF and BMI, TG, and HIF-1α. The statistical analysis using correlation test found that there was a significant correlation between VEGF and BMI, TG, HIF-1α _type 2 diabetes mellitus patients (p < 0.005). CONCLUSION: Therefore, our study showed that the correlation between VEGF and lipid profile (TG), BMI, and HIF-1α _was a positive correlation, which showed a directional relationship, if the VEGF level is high then the BMI, TG and HIF-1α _values are also high.

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“…Moreover, it has been reported that VEGF levels in plasma were positively correlated with fasting blood glucose level, glycosylated hemoglobin (HbA1c) level, and via the multiple linear regression analysis showed that HbA1c ratio were the independent predictors of VEGF levels in Type-2 DM patients ( 17 ). Another study has also shown that there was an increase in serum VEGF levels in the group of samples with Insulin Glucose Tolerance (IGT) and the Type-2 Diabetes mellitus groups compared to those in the healthy sample group ( 18 ). These higher VEGF levels in patients without microvascular complications group could be an indicator that endothelial angiogenesis is still ongoing and carries a risk of microvascular complications.…”

Section: Discussionmentioning

confidence: 95%

The Effect of Hypoxia Inducible Factor -1 Alpha and Vascular Endothelial Growth Factor Level in Type 2 Diabetes Microvascular Complications and Development

Rusdiana¹,

Moradi²,

Widjaja³

et al. 2022

Med Arch

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Background: Angiogenesis in diabetic patients is often caused by hyperglycemia induced by hypoxia Objective: The aim of this study was to analyze the serum level of Hypoxia Inducible Factor -1α (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) between March until Desember 2020. Methods: This is a cross-sectional analytic methods, 135 patients with Type 2 Diabetes 48 samples with Microvascular complication and 87 samples with non-microvascular complication were recruited from the various primary health care centers in Medan city and surrounding areas in North Sumatera. VEGF levels and HIF-1α tested were done with ELISA methods in the laboratory of Medical Faculty, Universitas Sumatera Utara. Statistical analysis was performed using the IBM SPSS Statistics version 24. The significance level was set up to 0.005. Results: The median HIF-1 levels in patients with microvascular complications were lower than those without microvascular complications, with a range of HIF-1α values in non-complicated samples (0.02-13.96) ng/ml and a range of HIF-1α values in vascular complications (0.52- 8.87) mg/dL. There was a significant difference in HIF-1α levels in patients with Type-2 DM with complications compared to those without complications (p<0.05). Median VEGF levels were higher in complicated Type-2 DM. There was no difference in VEGF levels in patients with Type-2 DM with complications compared to those without complications (p > 0.005). Conclusion: HIF-1α and VEGF levels showed the development in vascularity. With the higher level of HIF-1α, an increase in VEGF levels were found, indicating the angiogenesis is occurring. Although complications have not yet occurred, it is predicted that high VEGF values will cause vascular complications in the future.

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Serum vascular endothelial growth factor level is elevated in patients with impaired glucose tolerance and type 2 diabetes mellitus

Cited by 17 publications

References 34 publications

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

The Role Vascular Endothelial Growth Factor, Control Glycemic, Lipid Profile, and Hypoxia-inducible Factor 1-Alpha at Type 2 Diabetic Patients in North Sumatera, Indonesia

The Correlation between Serum Vascular Endothelial Growth Factor and Lipid Profile in Type 2 Diabetes Mellitus

The Effect of Hypoxia Inducible Factor -1 Alpha and Vascular Endothelial Growth Factor Level in Type 2 Diabetes Microvascular Complications and Development

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