Serum viral markers in Iranian patients with congenital bleeding disorder

Nassirtoosi, Mohssen; Lak, M; Karimi, Katayoun; Managchi, Mohammadreza; Samimi-Rad, Katayoun; Abdollahi, Alireza; Shahsiah, Reza

doi:10.5144/0256-4947.2008.453

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…The noticeable difference in the prevalence of HBcAb between the two studies may be due to the temporal differences. In the current study, the percentage of individuals born after 1993, the year newborn HBV vaccination started in Iran, was higher than in the study by Nassirtoosi et al [26]; hence, a higher number of individuals in our study were immune to HBV. As our study indicated that the prevalence of HBcAb steadily decreased upon the introduction of HBV screenings in blood donors in 1974, the implementation of HIV-Ab screenings in blood donors in 1989 further aided the reduction of the prevalence of HBcAb by removing high-risk individuals from the donor pool.…”

Section: Discussioncontrasting

confidence: 80%

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Trends in the Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Iranian Patients with Hereditary Bleeding Disorders

et al. 2023

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Background: Patients with hereditary bleeding disorders (HBDs) have always been vulnerable to transfusion-transmitted infections (TTIs) such as hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections due to being regular recipients of blood and blood products. This study aimed to detect the trends in the prevalence of HBV, HCV, and HIV infections by birthyear in Iranian patients with HBDs to show the efficacy of national interventions implemented to administrate control and to prevent these infections, i.e., blood safety, newborn HBV vaccination, and safe replacement treatments. Methods: In this retrospective study, the trends in the prevalence of hepatitis B core antibody (HBcAb), HCV antibody (HCV-Ab), and HIV antibody (HIV-Ab) in Iranian patients with HBDs born before 2012 were assessed using patients’ clinical archives. The determinants of HBV, HCV, and HIV infections were investigated in bivariable and multivariable logistic regression analyses. Results: Out of 1475 patients with HBDs, most were male (87.7%) and diagnosed with hemophilia A (52.1%) and severe bleeding disorder (63.7%). The prevalence of HBcAb, HCV-Ab, and confirmed HIV-Ab was 22.9%, 59.8%, and 1.2%, respectively. The trends in HBcAb, HCV-Ab, and HIV-Ab were all decreasing by birthyear and reached a stable level of 0% for patients with birthyears in 1999, 2000, and 1984, respectively. In multivariable analysis, birthyear was significantly associated with HBcAb prevalence. In the multivariable analysis, type of HBD; birthyear; bleeding severity; histories of receiving packed cells, fresh frozen plasma, and cryoprecipitate before 1996; and history of receiving factor concentrate before 1997 were highly associated with the prevalence of HCV-Ab. Moreover, in the bivariable analysis, birthyear and type of HBD were associated with HIV-Ab prevalence. Conclusion: This study demonstrated the decreasing trends in HBV, HCV, and HIV seroprevalence in Iranian patients with HBDs following preventive interventions such as HBV vaccination, blood safety measures, and the provision of safe replacement treatments.

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Section: Discussioncontrasting

confidence: 80%

“…In this study, the prevalence of HBcAb, the marker of HBV infection, was 22.9%. A similar study reported that the prevalence of HBcAb among patients with HBDs in Iran was 44% [26]. The noticeable difference in the prevalence of HBcAb between the two studies may be due to the temporal differences.…”

Section: Discussionmentioning

confidence: 83%

Trends in the Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Iranian Patients with Hereditary Bleeding Disorders

et al. 2023

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“…To The Editor: We have read with great interest the article of Dr Nassiri-Toosi in your journal 1 regarding the prevalence of hepatitis C infection in hemophilic patients. We disagree with the authors about the HCV prevalence rate in Iranian hemophilic patients.…”

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confidence: 99%

RE: Serum viral markers in Iranian patients with congenital bleeding disorder

Alavian

Tabatabaei

2009

Annals of Saudi Medicine

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“…The individuals concerned have taken coagulation factors and products after virus inactivation (after 1985). The study carried out at Imam Khomeini Hospital Tehran, Iran, and involved nearly 400 of the total hemophilic patients (adults or children) admitted there with HCV positivity of 80% to 85% 2. The reason for the increase could be explained by the use of coagulation factors contaminated with pre-1985 HCV and the lower referral of hemophilic patients to Imam Khomeini Hospital due to the breakout of HIV and the patient's fear for other sources of infection.…”

mentioning

confidence: 99%

Serum viral markers in Iranian patients with congenital bleeding disorder

Cited by 4 publications

References 15 publications

Trends in the Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Iranian Patients with Hereditary Bleeding Disorders

Trends in the Prevalence of Hepatitis B Virus, Hepatitis C Virus, and HIV Infections in Iranian Patients with Hereditary Bleeding Disorders

RE: Serum viral markers in Iranian patients with congenital bleeding disorder

Reply to Alavian and Tabatabaei: Serum Viral Markers in Iranian Patients with Congenital Bleeding Disorder

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