Serum Visfatin, Blood Glucose, Lipid Metabolism and Nonalcoholic Fatty liver Disease in Simple Obese Children

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) it is oneof the most common causes of liver disease worldwide. Visfatin is an adipocytokine hormone, which exerts an insulin-like effect by binding to the insulin receptor-1, we aim to investigate the correlation between serum Visfatin and NAFLD in Simple obese children.Method: This prospective study included 62 children clinically evaluated as obese and 35 apparently healthy children, age and sex matched as controls. Patients were recruited from the pediatric department of EL-Mina University, children's hospital. While controls were collected from healthy school children between September, 2016 and October, 2017.Fasting Visfatin, glucose, hemoglobin A 1c and lipid levels were assayed and abdominal ultrasonography was done for detection of NAFLD.Results: There was a statistically significant correlation between serum Visfatin level and BMI (p<0.01), cholesterol levels (p< 0.01), triglycerides levels (p< 0.01), LDLlevels (p< 0.01), HDLlevels (p< 0.01) in both overweight and obese groups. Conclusions:Visfatin plays an important role in pathogenesis of NAFLD.