Serum Vitamin a and Carotene Levels in Children With Rheumatic Fever

Wang, Pauline; Glass, Herbert L.; Goldenberg, Leon; Stearns, Genevieve; Kelly, Helen G.; Jackson, Robert L.; Chen, Jo Yun; Dimmitt, Norma Jean

doi:10.1001/archpedi.1954.02050090647001

Cited by 6 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…G. Weissmann (personal communication) observed a striking additive effect of the two agents on the histological structure of the liver in Xenopus larvae; either compound alone produced little change, but both together caused partial atrophy. Moreover Jackson and his colleagues (Wang, Glass, Goldenburg, Stearns, Kelly, and Jackson, 1954) found that the administration of pituitary corticotropin to patients with rheumatic fever raised the level of vitamin A in the blood stream. These observations suggest that in vivo the hormone may hasten the action of the vitamin by preventing it from being stored in the liver, so that a high concentration is rapidly produced in the blood.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Hydrocortisone on the Action of Excess Vitamin a on Limb Bone Rudiments in Culture

Fell

Thomas

1961

The Journal of Experimental Medicine

View full text Add to dashboard Cite

The effect of hydrocortisone has been studied in organ cultures of the cartilaginous long bone rudiments from 7-day chick embryos and of the well ossified limb bones from late fetal mice. In the chick rudiments, which grow rapidly in culture, the growth rate was much reduced by hydrocortisone, less intercellular material was formed, and the hypertrophic cells of the shaft were much smaller than in the controls in normal medium. In the late fetal mouse bones, which grow very little in culture, hydrocortisone had no obvious effect on growth but arrested resorption of the cartilage. These effects resemble those described by others in the skeleton of animals treated with cortisone or hydrocortisone. The influence of hydrocortisone on the response of the chick and mouse explants to excess vitamin A was investigated. In the presence of excess vitamin A, cartilage (chick, mouse) and bone (mouse) rapidly disintegrated, but when hydrocortisone also was added to the medium, this dissolution of the intercellular material was much retarded, though not suppressed. The retardative action of hydrocortisone on the changes produced by excess vitamin A in skeletal tissue in culture, contrasts sharply with the strongly additive effect of the two agents on the skeleton in the intact animal (Selye, 1958). It is suggested that this discrepancy between the results obtained in vitro and in vivo is probably due to systemic factors that operate in the body but are eliminated in organ cultures.

show abstract

Section: Discussionmentioning

confidence: 99%

The Influence of Hydrocortisone on the Action of Excess Vitamin a on Limb Bone Rudiments in Culture

Fell

Thomas

1961

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…The discrepancy between the experiments on isolated preparations and those on intact animals may be due to systemic factors that modify the distribution of the vitamin in the animal. Clark and Colburn (27) found that cortisone reduced the amount of vitamin A stored in the liver of rats deficient in vitamin A, while Wang et al (28) were able to elevate serum levels of vitamin A by administering corticotropin to patients with rheumatic fever. It is thus not unlikely that one effect of hydrocortisone is to elevate serum levels of the vitamin, by decreasing the liver stores.…”

Section: Discussionmentioning

confidence: 99%

Changes in Connective Tissue and Intestine Caused by Vitamin a in Amphibia, and Their Acceleration by Hydrocortisone

Weissmann

1961

The Journal of Experimental Medicine

View full text Add to dashboard Cite

In view of the theory that an excess of vitamin A causes release of cathepsins from intracellular lysosomes, hypervitaminosis A was induced orally in the larvae of Xenopus laevis. It was predicted that the tails of these amphibia would undergo resorption prior to metamorphosis, since the presence of abundant lysosomes, associated with measurable increases of catheptic activity, had previously been demonstrated in the resorbing tails of amphibia during metamorphosis. This prediction was confirmed; after 3 to 4 weeks of hypervitaminosis A, the tails of treated animals underwent partial resorption. Other transitory appendages, the rostral tentacles, collapsed after 2 weeks of treatment with an excess of vitamin A, an effect analogous to the collapse of rabbits' ears after intravenous papain. These effects were related to the loss of metachromatic extracellular material in these appendages. Excess of vitamin A caused kyphoscoliosis and prognathos in the larvae. The hypervitaminotic larvae always developed a mucinous diarrhea, which was associated with a remarkable overgrowth of metachromatic goblet cells of the intestine. The entire intestine of the treated animals was more advanced in development than that of control larvae at equivalent stages. All the effects of hypervitaminosis A were accelerated by the simultaneous administration of hydrocortisone. This was held to be due to liberation of vitamin A from hepatic stores by the steroid, and is in contrast to the retardation of hypervitaminosis A by hydrocortisone in vitro.

show abstract

Biochemical Aspects of Human Malnutrition in the Tropics

Bassir

1962

Monographiae Biologicae

View full text Add to dashboard Cite

Serum Vitamin a and Carotene Levels in Children With Rheumatic Fever

Cited by 6 publications

References 29 publications

The Influence of Hydrocortisone on the Action of Excess Vitamin a on Limb Bone Rudiments in Culture

The Influence of Hydrocortisone on the Action of Excess Vitamin a on Limb Bone Rudiments in Culture

Changes in Connective Tissue and Intestine Caused by Vitamin a in Amphibia, and Their Acceleration by Hydrocortisone

Biochemical Aspects of Human Malnutrition in the Tropics

Contact Info

Product

Resources

About