Serum vitamin A, retinol-binding protein, and prealbumin concentrations in protein-calorie malnutrition

Smith, Frank; Goodman, DeWitt S.; Zaklama, Mona S.; Gabr, Mohamed; Maraghy, Safinaz El; Patwardhan, V. N.

doi:10.1093/ajcn/26.9.973

Cited by 152 publications

(33 citation statements)

References 28 publications

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“…The association with RBP4 is consistent with that previously found in an independent group of individuals with NAFLD (5). However, RBP4 concentrations are influenced by total body retinol stores as well as by inflammation (6)(7)(8)(9), whereas fasting retinol more closely reflects retinol release by hepatic stellate cells. For each RBP4 protein secreted by the hepatocyte, 1 molecule of retinol is also secreted (15).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, circulating concentrations of retinol binding protein 4 (RBP4), a marker of retinol stores secreted by hepatocytes, were lower in overweight/obese individuals with nonalcoholic fatty liver disease (NAFLD) carrying the PNPLA3 148M mutant than in those with the 148I wild-type allele (5). RBP4 concentrations are influenced by total body retinol and by inflammation, whereas fasting retinol concentrations more closely reflect retinol release by hepatic stellate cells (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity ,

Mondul

Mancina

Merlo

et al. 2015

The Journal of Nutrition

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity ,

Mondul

Mancina

Merlo

et al. 2015

The Journal of Nutrition

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“…Vitamin A deficient children treated with an augmented dietary protein intake demonstrated an increase in serum protein markers as well as serum retinol levels [8]. In this extreme clinical scenario, retinol deficiency was successfully managed through this dietary intervention alone, without the addition of vitamin A rich foods or vitamin A supplementation [9]. The present findings support the intimate interaction that serum retinol levels have to carrier proteins which determine the bioavailability of serum retinol concentration and reinforce the interdependent relationship of these nutritional markers.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Deficiency after Gastric Bypass Surgery: An Underreported Postoperative Complication

et al. 2011

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Introduction. Few data are available on vitamin A deficiency in the gastric bypass population. Methods. We performed a retrospective chart review of gastric bypass patients (n = 69, 74% female). The relationship between serum vitamin A concentration and markers of protein metabolism at 6-weeks and 1-year post-operative were assessed. Results. The average weight loss at 6-weeks and 1-year following surgery was 20.1 ± 9.1 kg and 44.1 ± 17.1 kg, respectively. At 6 weeks and 1 year after surgery, 35% and 18% of patients were vitamin A deficient, (<325 mcg/L). Similarly, 34% and 19% had low pre-albumin levels (<18 mg/dL), at these time intervals. Vitamin A directly correlated with pre-albumin levels at 6 weeks (r = 0.67, P < 0.001) and 1-year (r = 0.67, P < 0.0001). There was no correlation between the roux limb length measurement and pre-albumin or vitamin A serum concentrations at these post-operative follow-ups. Vitamin A levels and markers of liver function testing were also unrelated. Conclusion. Vitamin A deficiency is common after bariatric surgery and is associated with a low serum concentration of pre-albumin. This fat-soluble vitamin should be measured in patients who have undergone gastric bypass surgery and deficiency should be suspected in those with evidence of protein-calorie malnutrition.

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“…Vitamin A circulates on demand from the hepatic reserves to peripheral tissues by means of specific carrier proteins: retinol binding protein and transthyretin. 36 The two proteins are synthesised by the liver and are sensitive to acute variations in proteinenergy status. If the diet is low in protein, vitamin A is not released from the liver and its transport is impaired owing to insufficient hepatic biosynthesis of the retinol binding protein and the transthyretin.…”

Section: Discussionmentioning

confidence: 99%

A randomised controlled trial to test equivalence between retinyl palmitate and beta carotene for vitamin A deficiency.

Carlier

Coste

Etchepare

et al. 1993

BMJ

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Objectives-To determine whether (3 carotene is therapeutically equivalent to retinyl palmitate in the formulation currently recommended by the World Health Organisation.Design-Randomised blind equivalence trial. Setting-Rural area in Senegal. Subjects-Children aged 2-15 years suffering from vitamin A deficiency as defined by abnormal results on eye cytology were randomly allocated treatment with retinyl palmitate (n=256) and (3 carotene (n=254).Main outcome measure-Reversion to normal results on eye cytology as defined by the reappearance of goblet cells and normalisation of the epithelial cells.Results-Seven weeks after the supplement was given the percentages were 51.2% (124/242) children taking retinyl palmitate and 50.0% (123/246) of those taking ( carotene, who had reverted to normal eye cytology, a difference of 12% (95Gb confidence interval 0.8% to 1.6%). According to an equivalence testing procedure, the two treatments were statistically equivalent; the null hypothesis of non-

show abstract

Serum vitamin A, retinol-binding protein, and prealbumin concentrations in protein-calorie malnutrition

Cited by 152 publications

References 28 publications

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity ,

PNPLA3 I148M Variant Influences Circulating Retinol in Adults with Nonalcoholic Fatty Liver Disease or Obesity ,

Vitamin A Deficiency after Gastric Bypass Surgery: An Underreported Postoperative Complication

A randomised controlled trial to test equivalence between retinyl palmitate and beta carotene for vitamin A deficiency.

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