Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus

Li, Wei; Zhao, Jun; Zhu, Lijing; Peng, You‐Fan

doi:10.1177/20420188221102800

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…According to this study, serum vitamin B12 level was found not to be associated with blood glucose and HbA1c. A recent study has found that vitamin B12 replacement could improve glycemic control and blood glucose fluctuations (18). However, another study demonstrated that hyperglycemia alters vitamin B12 usage in the body and thus increases serum B12 levels (19).…”

Section: Resultsmentioning

confidence: 99%

Vitamin B12 deficiency in turkish patients with Type 2 Diabetes Mellitus

2023

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Objective: Type 2 diabetes (T2DM) disease and related changes in blood parameters bring essential health risks. This study was carried out to determine the frequency of vitamin B12 deficiency in T2DM patients, the effect of B12 deficiency on blood glucose, HbA1c control and lipid parameters, and the B12 level in diabetes patients using metformin. Material and Methods: 287 patients with T2DM who were followed up in the Endocrinology department of Istanbul Training and Research Hospital were evaluated. After the patients called for control had fasted for 8 hours, blood tests were performed, and biochemical parameters were determined with standard laboratory techniques. Vitamin B12 <180 mg/dl was accepted as a deficiency, and patients were divided into groups regarding vitamin B12 deficiency. The chemiluminescence method was used to determine serum Vitamin B12 levels. Data were analyzed using SPSS version 22.0 (IBM Corporation, Armonk, NY, USA). Results: A total of 287 T2DM patients were included in the study. B12 deficiency is present in 29.8% of T2DM patients. Vitamin B12 values were found to be lower in patients with T2DM using metformin (280.2 pg /ml ±151.06 pg/ml, p<0.05); however, lower vitamin B12 values did not have a significant effect on blood sugar control (p=0,3), and hypovitaminosis Vitamin B12 was associated with elevated hypertriglyceridemia (p=0,03). Conclusion: According to the current study, serum vitamin B12 level was not associated with blood glucose and HbA1c; a relationship was found between vitamin B12 deficiency and higher hypertriglyceridemia. A significant proportion of T2DM patients using metformin had lower levels of vitamin B12 compared to T2DM patients not using metformin. Vitamin B12 levels should be monitored regularly in the follow-up of patients with T2DM using metformin.

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Section: Resultsmentioning

confidence: 99%

Vitamin B12 deficiency in turkish patients with Type 2 Diabetes Mellitus

2023

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Comorbid Diabetes Is Associated With Dyspnea Severity and Cardiometabolic Biomarkers in Black Adults With Heart Failure

Butts,

Kamara,

Morris

et al. 2024

Nursing Research

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Background Comorbidities such as type 2 diabetes mellitus significantly and adversely influence heart failure outcomes, especially in Black adult populations. Likewise, heart failure has a negative effect on diabetes and cardiometabolic outcomes. Dyspnea, a common symptom of heart failure, often correlates with disease severity and prognosis. However, the relationship between comorbid diabetes, dyspnea severity, and cardiometabolic biomarkers in Black adults with heart failure remains understudied. Objectives The purpose of this pilot study was to examine differences in the distressing heart failure symptom of dyspnea and in cardiometabolic and inflammatory biomarkers in Black adults living with heart failure with and without diabetes. Methods Black adults with heart failure were enrolled in this cross-sectional pilot study. Cardiometabolic and inflammatory biomarkers were measured via multiplex immunoassay. Univariate general liner models were used to identify group differences between persons with heart failure with comorbid diabetes and those without, controlling for age, sex, and comorbid burden. Results Participants were mostly female with a mean age of 55 years and mean left ventricular ejection fraction of 33%. Participants with diabetes exhibited higher dyspnea scores compared to those without diabetes, indicating greater symptom burden. Moreover, individuals with comorbid diabetes demonstrated higher levels of cardiometabolic and inflammatory markers. Discussion Comorbid diabetes was associated with higher dyspnea severity and adverse cardiometabolic profiles in Black adults with heart failure. These findings underscore the importance of targeted interventions addressing diabetes management and cardiometabolic risk factors to improve symptom control and outcomes in this high-risk population. Further research is warranted to elucidate the underlying mechanisms and develop tailored therapeutic strategies for managing comorbidities in persons with heart failure, particularly in minoritized communities.

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Vitamin B12 and diabetic neuropathies

Serhiyenko,

Markevych,

Sehin

et al. 2024

Mìžnarodnij endokrinologìčnij žurnal

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Vitamin B12 (cyanocobalamin, cobalamin) is an essential cofactor in two important biochemical pathways: methylmalonic acid metabolism and methionine synthesis from homocysteine. In addition to hematologic abnormalities (megaloblastic anemia or even pancytopenia), cobalamin deficiency can cause neurologic symptoms similar to diabetic neuropathy (DN). The underlying molecular mechanisms of DN are still unclear. Most studies have identified the contribution of low-grade chronic inflammation (LGCI) and oxidative stress (OS) to the development of DN. Immunohistochemical studies of calf muscle nerve biopsies obtained from patients with diabetes mellitus and DN indicate activation of the LGCI pathway caused by increased levels of advanced glycation end products, which leads to increased OS. Similar results were found in patients with vitamin B12 deficiency. Thus, clinical changes in patients with DN may be caused by cellular cobalamin deficiency. In vitro and in vivo studies have demonstrated that vitamin B12 has intrinsic antioxidant activity. Thus, cobalamin, regardless of its classical function as a cofactor, can act as an intracellular, in particular intramitochondrial, antioxidant. This may serve as a rationale for the use of vitamin B12 in the treatment of DN, even in the early subclinical stages. The purpose of this review was to discuss the role of vitamin B12 in the prevention and treatment of DN, as well as to analyze new trends and directions for future research. The search was conducted in Scopus, Science Direct (from Elsevier) and PubMed, including MEDLINE databases. The keywords used were vitamin B12, cobalamin, diabetes mellitus, neuropathy, cardiac autonomic neuropathy. A manual search of the bibliography of publications was used to identify study results that could not be found during the online search.

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Serum vitamin B12 levels and glycemic fluctuation in patients with type 2 diabetes mellitus

Cited by 3 publications

References 21 publications

Vitamin B12 deficiency in turkish patients with Type 2 Diabetes Mellitus

Vitamin B12 deficiency in turkish patients with Type 2 Diabetes Mellitus

Comorbid Diabetes Is Associated With Dyspnea Severity and Cardiometabolic Biomarkers in Black Adults With Heart Failure

Vitamin B12 and diabetic neuropathies

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