Serum vitamin B12 levels as indicators of disease severity and mortality of patients with acute‐on‐chronic liver failure

High vitamin B12 levels are not associated with increased mortality risk for ICU patients after adjusting for liver function: A cohort study

“…All the liver function measures and rates of liver disease and cancer generally increased with increasing B12 levels with the exception (as might be expected) of albumin which decreased with increasing B12 levels (p<0.0001 for all). These results are in agreement with Dou et al 12 , Lin et al 11 , Ermens et al 9 and others who found that poor liver function is associated with elevated B12 levels.…”

“…Lin et al 11 found that elevated B12 levels were associated with increased mortality in hepatocellular carcinoma patients (N=90). Dou et al 12 studied N=149 patients with liver failure and found that B12 levels were positively correlated with mortality after adjusting for the Model for End-stage Liver Disease (MELD) score 13 . However, neither study focused on ICU patients.…”

Paradoxical increase of plasma vitamin B12 and folates with disease severity in anorexia nervosa

“…The fact that vitamin B 12 levels were not reduced in nutritionally depleted individuals (AN) certainly deserves further reflections. The finding could not have been due to dietary supplementation or integration, and was most probably due to the presence of liver dysfunction, inducing B 12 hypervitaminosis by leakage, as already suggested , . The detection of an increase in ALT and AST values, above normal upper limits, respectively, in 20 and ∼12% of the participants, allowed us to confirm the presence of moderate liver dysfunction (maximum values were 40.0 and 69.0 U l −1 for AST and ALT, respectively, see Table ) in our population, in agreement with several previous reports on this disease , , .…”

“…Liver damage is associated not only with hypertransaminasemia but also with the increase in plasma levels of vitamin B 12 , due to leakage , . Normally, the liver stores a vitamin B 12 (cobalamin) supply of several milligrams, which is sufficient to cover the daily need for several years .…”

“…Normally, the liver stores a vitamin B 12 (cobalamin) supply of several milligrams, which is sufficient to cover the daily need for several years . Diseases that lead to elevated blood levels of vitamin B 12 include hematologic disorders ( e.g ., acute and chronic myelogenous leukaemia), and liver diseases (e.g., acute hepatitis or hepatocellular carcinoma) . However, dietary supplementation or integration that may elevate plasma vitamin B 12 should be considered as the primary cause of any increase …”