Serum Vitamin D and Cardiometabolic Markers: A Comparative Study in Adult Men Based on Body Mass Index

Abstract

INTRODUCTION: Deficiency of vitamin D has been implicated in several disorders, including skeletal, immune, neural, metabolic, and cardiovascular diseases (CVDs). The impact of vitamin D deficiency on CVDs is potentially through derangement of cardiometabolic profile. The present work assessed the relationship between serum vitamin D levels and cardiometabolic markers in adult men. MATERIALS AND METHODS: A cross-sectional analytical study (n=160) was conducted on adult men between the ages 35-50 years without a history of CVDs and/or diabetes, liver, or kidney disorders. Serum vitamin D, lipid profile (cholesterol, triacylglycerol; TAG, low[1]density lipoprotein; LDL, high-density lipoprotein; HDL), and renal function tests (urea, creatinine) were measured using enzyme‑linked immunosorbent assays (ELISA). Pearson’s correlation was used for assessing correlations between the studied parameters. Participants were further grouped as underweight, normal weight, overweight, and obese based on their BMI values, and one-way ANOVA and post-hoc Tukey’s tests were done to observe group mean differences. RESULTS: Vitamin D and HDL were positively correlated (r=0.395, p=0.000) while negative correlation of serum vitamin D levels was seen with TAG (r=-0.539, p=0.000), cholesterol (r=-0.325, p=0.000), LDL (r=-0.541, p=0.000) and urea (r=-0.514, p=0.000). Levels of serum vitamin D (p=0.000) and HDL (p=0.000) were lower while levels of TAG (p=0.000), cholesterol (p=0.000), LDL (p=0.000) and urea (p=0.000) were higher in the overweight and obese groups. CONCLUSION: Inadequate serum vitamin D status is associated with dyslipidaemia in adult men. Moreover, obese and overweight men have lower serum vitamin D levels with pronounced dyslipidaemia, thus highlighting vitamin D as a potential cardiometabolic risk factor.

Knowledge, Attitude, and Practices Regarding Vitamin D in Middle-Aged Pakistani Population and the Impact of Sun Exposure on Their Serum Vitamin D Levels

“…Vitamin D, a fat-soluble secosteroid hormone, is a key contributor to musculoskeletal health through its role in calcium and phosphorus homeostasis [1]. Data accrued over the last two decades has shown that low vitamin D levels are associated with a wide range of clinical disorders such as immune dysfunction, cardiovascular diseases, autoimmunity, and neurological deficits, suggesting the involvement of vitamin D in multiple physiological processes [2].…”

Comparison of Outcomes of PHILOS for Proximal Humerus Fracture in Middle Aged Patients Based on Early Surgery vs Late Surgery

“…In our elderly population which is significantly deficient in Calcium and Vitamin D3 and thus more prone to early onset osteoporosis 9 . In international studies the outcome showed that PHILOS plate gives maximum fracture stabilization in the treatment of proximal humeral fractures of old age.…”

Future of Hydrogen as an Alternative Fuel for Next-Generation Industrial Applications; Challenges and Expected Opportunities

“…Hydrogen has been found to have anti-inflammatory, anti-allergenic, and anti-apoptotic properties in biomedical research (i.e., programmed cell death) [215]. The use of hydrogen in the treatment of rheumatoid arthritis, brain stem infarction, diabetes mellitus, neurodegenerative illnesses, cancer, and exercise-or sportsinduced oxidative stress are among the other therapeutic applications of hydrogen that have been established [216][217][218][219][220][221][222][223][224]. Hydrogen is a physiological and metabolic regulating component that regulates protein phosphorylation and gene expression [225].…”