Serum Vitamin D and Parathyroid Hormone Profiles in Patients With Various Stages of Renal Disease

Abdel-Gayoum, Abdelgayoum Ahmed

doi:10.21767/amj.2015.2252

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average age of participants in the MESA (62 years) was markedly higher than in ARICs (range: 56–57 years) and PREVENDs (49 years). In general, kidney function declines with age and changes in PTH levels are predominantly present in patients with advanced stages of chronic kidney disease . Independent from kidney function, increasing age itself is associated with increased plasma PTH concentrations, and it has even been suggested to take this effect into account when assessing calcium disorders in elderly individuals .…”

Section: Discussionmentioning

confidence: 72%

Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study

et al. 2016

View full text Add to dashboard Cite

BackgroundHeart failure (HF) is a major problem in the Western world, with increasing prevalence and incidence. Because HF cannot be cured, prevention of HF is of utter importance. Calcidiol, calcitriol, and parathyroid hormone (PTH) have been identified as risk factors for cardiovascular disease. However, their association with new onset HF remains to be established. We investigated whether calcidiol, calcitriol, and PTH could be used to identify those subjects at risk for new onset HF, and if they had additive predictive value over established risk predictors like N‐terminal‐pro Brain‐type natriuretic peptide and highly sensitive Troponin‐T.Methods and resultsWe examined 7470 HF‐free participants in Prevention of Renal and Vascular End‐stage Disease, a community‐based cohort study in Groningen, the Netherlands (latitude 53°N, mean age: 49 years, 48% male). During follow‐up time of 12.6 years (interquartile range: 12.3–12.9), 281 participants (4%) developed HF: 181 (66%) HF with reduced and 94 (34%) HF with preserved ejection fraction (HFrEF [left ventricular ejection fraction ≤ 40%], and HFpEF [left ventricular ejection fraction ≥ 50%], respectively). Mean (±SD) of calcidiol was 58 (±24) nmol/L, mean calcitriol 145 (±48) pmol/L, and median (interquartile range) PTH was 3.7 (3.0–4.6) pmol/L. Calcidiol levels were univariately associated with new onset HF [hazard ratio (HR) 0.82 (95% CI 0.69–0.96)], but calcitriol levels were not [HR 0.85 (95% CI 0.71–1.03)]. PTH levels kept their predictive value after adjustment for age, sex, and day of blood withdrawal (HR 1.26 [95% CI 1.04–1.53]). However, in our full model this association was lost [HR 1.10 (95% CI 0.92–1.32)]. Calcidiol, calcitriol, and PTH could not differentiate between new onset HFrEF or HFpEF.ConclusionsAfter adjustment for confounding factors, a single measurement of plasma calcidiol, calcitriol, or PTH was not associated with risk of developing HF. Screening for these markers to identify subjects at risk for new onset HF cannot be advocated.

show abstract

Section: Discussionmentioning

confidence: 72%