Serum Vitamin D And Serum Ferritin Levels In Male Pattern Hair Loss :Is There A role?

Tahlawy, Samar M.R.; Alkhayat, Mohammed A.; Ali, Hassan; Samhoud, Eman A.A.

doi:10.21608/fumj.2021.184699

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…These findings are consistent with the outcomes of a study led by Tahlawy et al where they noted a mean vitamin D level of 37.1 ng/ml in cases, contrasting with a mean of 44.2 ng/ml in controls. 22 The study revealed significantly lower Vitamin D levels in cases compared to controls, with a p=0.02. Similar results were also reported by Hagag et al, Moneib et al, Rasheed et al, and Banihashemi et al their findings indicated significantly lower levels of vitamin D in cases compared to matched controls.…”

Section: Discussionmentioning

confidence: 77%

The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study

Kumar,

Iftikhar,

Dubey

et al. 2024

Int J Res Dermatol

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Background: Androgenetic alopecia (AGA) is a common hereditary condition characterized by progressive hair loss influenced by androgens. Vitamin D has been implicated in various hair disorders, yet its association with AGA, particularly in South Asian populations, remains inconclusive. Methods: We conducted a case-control study involving 100 male subjects from eastern Uttar Pradesh, India, comprising 50 AGA cases and 50 age-matched controls. Serum vitamin D levels were measured, and participants underwent clinical evaluations. Statistical analyses were performed using unpaired t tests and chi-square tests. Results: Vitamin D deficiency (<20 ng/ml) was significantly more prevalent in AGA cases (56%) compared to controls (24%) (p<0.001), with an odds ratio of 4.0303. Mean serum vitamin D levels were significantly lower in cases (33.1±10.6 ng/ml) than controls (40.3±9.51 ng/ml) (p=0.0005). Severe AGA cases exhibited lower vitamin D levels compared to mild to moderate cases, although the difference was not statistically significant (p=0.32). Conclusions: This study highlights the importance of vitamin D in AGA pathogenesis and suggests the need for routine monitoring of serum vitamin D levels in AGA patients. Further large-scale studies are warranted to confirm these findings and investigate the efficacy of vitamin D supplementation as a therapeutic intervention for AGA.

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Section: Discussionmentioning

confidence: 77%

The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study

Kumar,

Iftikhar,

Dubey

et al. 2024

Int J Res Dermatol

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“…Similarly, Moneib et al 11 reported significantly lower serum 25(OH) D levels in patients with female androgenetic alopecia than in controls, and Samar et al 12 reported significantly lower vitamin D levels in male androgenetic alopecia cases.…”

Section: Discussionmentioning

confidence: 92%

A comparative study on the association of serum ferritin and vitamin D, and B12 levels among individuals with hair loss

Salecha,

Sai-Sameer,

Annamreddy

et al. 2024

PJDV

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Objectives:The objective of this study was to study the most frequent type of hair loss in different age groups, and the prevalent micronutrient deficiency linked to hair loss and to compare the association of serum ferritin, vitamin D, and vitamin B12 levels with hair loss among cases and controls. Methods: This was a cross-sectional study which included a total of 100 subjects with 50 hair loss cases and 50 age and sex-matched controls. Serum levels of vitamin D, vitamin B12, and ferritin were measured in all subjects. Results: Most of the subjects were between 20 and 30 years of age. There was a predominance of telogen effluvium followed by male androgenetic alopecia in all age groups. Females had considerably lower levels of serum ferritin compared to males among cases, with p-value of 0.0001. Vitamin D, vitamin B12, and serum ferritin were significantly low among cases compared to controls, with p-values of 0.0001, 0.01, and 0.006, respectively. Conclusion: This study suggests that low levels of serum vitamin B12 and serum ferritin and particularly vitamin D might play an appreciable role in hair loss especially telogen effluvium among females. Evaluation of these parameters could aid the clinician in opting for a more precise therapeutic modality, but identification of the exact etiology remains a primary concern as it is multifactorial, which paves path to appropriate and effective treatment.

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“…Because the literature has widely highlighted the importance of ferritin levels in regards to hair loss, a few studies have been performed to determine if low ferritin levels are also significant in males experiencing hair loss. In the study described previously by Tahlawy et al, the researchers also assessed 30 males with androgenetic alopecia and compared their serum ferritin levels with 30 healthy males [66]. The results showed no statistically significant differences in ferritin levels in patients with androgenetic alopecia compared to controls.…”

Section: Men Vs Womenmentioning

confidence: 94%

“…A case-control study performed in 2021 investigated the role of vitamin D serum levels in 30 males with androgenetic alopecia [66]. Results showed significantly lower vitamin D levels in males with androgenetic alopecia compared to healthy controls (p < 0.01).…”

Section: Vitamin Dmentioning

confidence: 99%

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Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

Natarelli

Gahoonia

Sivamani

2023

JCM

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The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen. Anagen is a highly mitotic phase characterized by the production of a hair shaft from the hair follicle, whereas catagen and telogen describe regression and the resting phase of the follicle, respectively, ultimately resulting in hair shedding. While 9% of hair follicles reside in telogen at any time, a variety of factors promote anagen to telogen transition, including inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and cellular division inhibiting medication. Conversely, increased blood flow, direct stimulation of the hair follicle, and growth factors promote telogen to anagen transition and subsequent hair growth. This review seeks to comprehensively describe the hair cycle, anagen and telogen balance, factors that promote anagen to telogen transition and vice versa, and the clinical utility of a variety of lab testing and evaluations. Ultimately, a variety of factors impact the hair cycle, necessitating a holistic approach to hair loss.

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Serum Vitamin D And Serum Ferritin Levels In Male Pattern Hair Loss :Is There A role?

Cited by 4 publications

References 9 publications

The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study

The evaluation of serum vitamin D3 in androgenetic alopecia: a case-control study

A comparative study on the association of serum ferritin and vitamin D, and B12 levels among individuals with hair loss

Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss

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