Serum vitamin d level and susceptibility to multidrug-resistant tuberculosis among household contacts

Herlina, Netti; Sinaga, Bintang Yinke Magdalena; Siagian, Parulian; Mutiara, Erna

doi:10.1088/1755-1315/125/1/012143

Cited by 4 publications

(10 citation statements)

References 8 publications

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“…A study on healthy woman in Indonesia at the same location where this study was done found that no subject had a sufficient vitamin D level; most of them were deficient or insufficient [22]. This might explain the result of the study by Herlina in Indonesia, who found no difference in vitamin D level between MDR-TB patients and healthy household contacts [15].…”

Section: Discussionmentioning

confidence: 89%

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The role of FokI polymorphism of vitamin D receptor gene and vitamin D level in multidrug-resistant tuberculosis occurrence in Medan city, Indonesia

Sinaga¹,

Amir²,

Siagian³

2018

Arch Med Sci Civil Dis

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Introduction: Multidrug-resistant tuberculosis (MDR-TB) has become a new problem in the world. Many factors have been associated with MDR-TB occurrence. Some studies have demonstrated a role of vitamin D level and vitamin D receptor (VDR) gene polymorphism in MDR-TB. The aim of this study is to explore the role of FokI polymorphisms of the VDR gene and vitamin D level in MDR-TB occurrence in Medan city, Indonesia. Material and methods: This is a case-control study. Cases were 43 MDR-TB patients from the MDR-TB polyclinic Adam Malik Hospital in Medan, Indonesia. The control group comprised 56 new pulmonary TB cases with positive AFB sputum smear. Patients who were HIV positive, known to have diabetes mellitus or other severe disease, taking immunosuppressive drugs and vitamin D were excluded for both groups. Genetic polymorphisms of the VDR gene were analyzed using PCR-RFLP. Vitamin D level was analyzed using the ELISA procedure. Results: The frequencies of FokI genotypes were FF 39.5%, Ff 53.5%, ff 7.0% for MDR-TB patients and FF 39.3%, Ff 46.4.% and ff 14.3% for controls. There was no significant association between FokI genotype of the VDR gene and MDR-TB. Vitamin D level in MDR-TB was 53.5% sufficient, 39.5% insufficient and 7.0% deficient. Vitamin D level was 41.1% sufficient, 46.4% insufficient and 12.5% deficient in TB non-MDR. There was no significant association between vitamin D level and MDR-TB. Conclusions: No role of FokI polymorphism of the VDR gene and vitamin D level in MDR-TB occurrence was found.

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Section: Discussionmentioning

confidence: 89%

“…Iftikhar et al found the same result that the vitamin D level was lower in MDR-TB patients than non-MDR TB patients and healthy controls [14]. In contrast, Herlina et al found no difference in vitamin D level between MDR-TB patients and healthy household contacts in Indonesia [15].…”

Section: Introductionmentioning

confidence: 92%

The role of FokI polymorphism of vitamin D receptor gene and vitamin D level in multidrug-resistant tuberculosis occurrence in Medan city, Indonesia

Sinaga¹,

Amir²,

Siagian³

2018

Arch Med Sci Civil Dis

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“…A total of 24 studies, 1,21–27,29–33,45–47,52–54,56–60 3295 tuberculosis patients and 18 080 healthy controls were included in the meta-analysis of comparing the blood 25-hydroxyvitamin D concentration of the tuberculosis patients with that of the healthy controls (Fig. 3).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 47 studies, seven studies reported the vitamin A status, two studies reported the vitamin C status, 33 studies reported the vitamin D status or the number of people with VDD, and five studies reported the vitamin E status in the tuberculosis group versus the control group. The 47 included studies included 32 case-control studies, 1,15,21,[24][25][26]28,[31][32][33][34][45][46][47][48][49][50][51][52][53] seven cross-sectional studies, 21,22,27,29,30,54,55 and eight cohort or nested case-control studies. 16,35,[56][57][58][59][60][61] The study characteristics are shown in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Fei

Wang

et al. 2022

Food Funct.

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Low serum vitamin D in North Indian multi-drug resistant pulmonary tuberculosis patients: the role of diet and sunlight

Rathored,

Sharma,

Chauhan

et al. 2023

Annals of Medicine

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Background: Tuberculosis (TB) and malnutrition are major global health problems, with multidrug-resistant (MDR) TB complicating international efforts. The role of vitamin D in susceptibility to and as an adjunctive treatment for TB is being studied extensively, although no study has included MDR-TB patients in context to dietary profile with vitamin D levels and sunlight exposure. Objective: This study aimed to estimate vitamin D serum levels and examine their association with dietary intake of vitamin D and sun exposure in patients with MDR-TB. Methods: North Indian participants were enrolled in three groups: MDR-TB, drug-susceptible pulmonary TB (DS-PTB), and healthy controls. All consenting participants underwent the estimation of macro- and micronutrient intake and sunlight exposure using structured questionnaires. Serum biochemistry, including 25-hydroxyvitamin D and calcium levels, was measured, and the correlation between variables was determined. Results: 747 participants were enrolled. Significant differences among the three groups were found in mean serum 25-hydroxyvitamin D levels, body mass index, macronutrient intake, dietary vitamin D and calcium content, and sun exposure index (SEI). All except sun exposure (SEI was highest in DS-PTB patients) were found to follow the trend: MDR-TB < DS-PTB < healthy controls. The mean serum vitamin D levels of all groups were deficient and correlated positively with dietary intake and SEI. Conclusion: In this study’s we found significant association of serum vitamin D concentrations, dietary intake and sunlight exposure in MDR-TB, DS-PTB patients and healthy controls. Dietary intake may be more important than sun exposure in determining serum levels. However, the significance of this finding is uncertain. Further studies are required to confirm the association, direction, and potential for vitamin D supplementation to treat or prevent MDR-TB infection.

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Serum vitamin d level and susceptibility to multidrug-resistant tuberculosis among household contacts

Cited by 4 publications

References 8 publications

The role of FokI polymorphism of vitamin D receptor gene and vitamin D level in multidrug-resistant tuberculosis occurrence in Medan city, Indonesia

The role of FokI polymorphism of vitamin D receptor gene and vitamin D level in multidrug-resistant tuberculosis occurrence in Medan city, Indonesia

Associating the blood vitamin A, C, D and E status with tuberculosis: a systematic review and meta-analysis of observational studies

Low serum vitamin D in North Indian multi-drug resistant pulmonary tuberculosis patients: the role of diet and sunlight

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