Serum Vitamin D levels and Alopecia areata- A hospital based case-control study from North-India

Rehman, Fozia; Dogra, Naina; Wani, Mashkoor

doi:10.4103/ijt.ijt_3_19

Cited by 22 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The child we are reporting has total alopecia which supports the possibility of VDR mutation in the DNA-binding domain with severe hormone resistance. 8,9 The early diagnosis of HVDDR is often misdiagnosed as alopecia, a dermatological condition as its early sign is alopecia. The child in our case had alopecia as early as 4 months, but the correct diagnosis was made only when rachitic changes became apparent.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hereditary Vitamin-D Dependent Rickets Type II: A Case Report

et al. 2021

View full text Add to dashboard Cite

Hereditary vitamin D dependent rickets type II is a rare genetic disorder in children characterized by early onset of rickets and deranged biochemical parameters. Low serum calcium level, high alkaline phosphatase, high parathyroid hormone, and high values of 1,25-dihydroxy vitamin D are characteristic biochemical findings. We are reporting a rare case of Vitamin D Dependent Rickets and subsequent improvement after addition of cinacalcet. This is a case report of a 2.5-year-child with Hereditary Vitamin D Dependent Rickets type II receiving cinacalcet as adjunct to oral calcium and calcitriol. Oral cinacalcet (0.25mg/kg/day) was added to the regimen as an adjunct after treatment failure with high dose of oral calcium and calcitriol. A significant improvement in radiological findings and normal homeostasis of calcium, phosphate and parathyroid hormone was achieved after initiation of cinacalcet.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The child we are reporting has total alopecia which supports the possibility of VDR mutation in the DNA-binding domain with severe hormone resistance. 8 , 9 …”

Section: Discussionmentioning

confidence: 99%

Hereditary Vitamin-D Dependent Rickets Type II: A Case Report

et al. 2021

View full text Add to dashboard Cite

show abstract

“…During pregnancy, less than 20 ng/ml of serum 25(OH)D levels is considered as de cient, 20-29.99 ng/ml as insu cient, while more than or equal to 30 ng/ml is considered as su cient [17] .…”

Section: Secondary Objectivesmentioning

confidence: 99%

Unlocking the Mystery of the Role of Vitamin D in Iron Deficiency Anemia in Antenatal Women: A Case Control Study in a Tertiary Care Hospital in New Delhi

Hitesh,

Khatuja,

Agrawal

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Vitamin D deficiency and anemia are clinical conditions that coexist during pregnancy. High prevalence of Vitamin D deficiency ranging from 50–94% is seen throughout the country. The aim of the study was to discover the association between Vitamin D status and iron deficiency anemia during pregnancy. Improving the vitamin D status of pregnant women is crucial to prevent iron deficiency anemia and can improve maternal and fetal outcomes. Methods A case control study including 94 primigravida women of age within the age group 18 to 30 years, divided into two groups: a Case Group of 48 patients with already diagnosed iron deficiency anaemia (mild to moderate) and a Control Group of 46 antenatal women with normal haemoglobin levels. Data on sociodemographic, clinical characteristics and the levels of 25(OH) Vitamin D was estimated in both the groups. The association of 25(OH)D levels and anaemia was then determined using suitable statistical analysis. Results Among pregnant women affected with anemia, 75% of women had serum Vitamin D concentrations < 20ng/ml compared to 52.2% of women in the controls. Maternal serum vitamin D was significantly lower in pregnant women affected with anemia (p = 0.024). A positive correlation was found between hemoglobin and vitamin D levels in pregnant women (Pearson’s r = 0.200, p = 0.05). Conclusions These findings provide evidence suggesting that Vitamin D deficiency or insufficiency during pregnancy may be a risk factor for anemia and correction of Vitamin D levels can improve hemoglobin levels. Educational efforts should be made to include safe vitamin D intake in antenatal care.

show abstract

“…Reduced vitamin D levels have been connected to a variety of autoimmune disorders and inflammatory conditions, including rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus [11]. Furthermore, VDRs are expressed in the keratinocytes of hair follicles, which is essential for the proper hair cycle [12]. The significant correlation between serum 25hydroxyvitamin D [25-(OH)D] and FPHL has not been thoroughly investigated; however, recent studies have investigated the possible relation of serum 25-(OH) D and other hair diseases [13].…”

Section: Introductionmentioning

confidence: 99%

Possible Association of Female-Pattern Hair Loss with Alteration in Serum 25-Hydroxyvitamin D Levels

Hailat¹,

Mughal²,

Malik³

et al. 2023

PJMHS

View full text Add to dashboard Cite

Background and Aim: Most women who experience diffuse hair loss suffer from female-pattern hair loss (FPHL). Several mechanisms other than androgen have been suggested as contributing to the process. Serum 25-hydroxy vitamin D [25-(OH) D] has been associated with other hair disorders. The present study aimed to assess the female-pattern hair loss possible association with variation in serum 25-hydroxyvitamin D levels. Patients and Methods: This case-control study was conducted on 72 FPHL diagnosed female patients attending dermatology department of Tertiary Care Hospitals in Jamshoro and Karachi from November 2021 to October 2022. Females aged 18-40 years with skin prototypes III and IV were enrolled. About 72 healthy females were considered as control group. Study protocol was approved by the institutional research and ethical committee. Careful history, socioeconomic status, FPHL family history, menstrual history, and drug intake were recorded from cases and control. Patients were classified as having stage I, II, or III FPHL based on a clinical evaluation of the pattern of hair loss using Ludwig's scale. 25-OHD levels over a period of 4 months were measured to minimize seasonal bias. Females with 25-OHD levels <20 ng/ml were deficient, insufficient 21–29 ng/ml, sufficient >30 ng/ml, and intoxication >150 ng/ml. SPSS version 26 was used for data analysis. Results: The overall mean age was 28.6±2.4 years. Age-wise distribution of patients were as follows: 9 (12.5%) in 18-25 years, 24 (33.3%) in 26-30 years, 21 (29.2%) in 31-35 years, and 18 (25%) 36-40 years. Serum 25-(OH) D levels in FPHL patients were significantly lower (15.4 ± 8.25 ng/ml) than in controls (46.42 ± 19.92 ng/ml). The mean vitamin D level did not differ significantly between patients with and without family history (14.46 ± 8.62 and 13.9 ± 8.24 ng/ml, respectively. The mean vitamin D level differed significantly between the three Ludwig's degrees (13.15 ± 8.49, 14.23 ± 6.74, and 24.9 ± 6.42 ng/ml, respectively): between degrees I and III, as well as between degrees II and III. Conclusion: The present study showed that hair loss varied significantly across all age groups. Premenopausal women with vitamin D deficiency have higher rates of hair loss, which is most profound in the age groups 26-30, followed by 25-30. Furthermore, changes in serum 25-(OH) D levels, whether deficient or sufficient, may play a role in the etiology of FPHL. Keywords: Female Pattern Hair Loss (FPHL), Vitamin D, Serum 25-hydroxy vitamin D

show abstract

Serum Vitamin D levels and Alopecia areata- A hospital based case-control study from North-India

Cited by 22 publications

References 30 publications

Hereditary Vitamin-D Dependent Rickets Type II: A Case Report

Hereditary Vitamin-D Dependent Rickets Type II: A Case Report

Unlocking the Mystery of the Role of Vitamin D in Iron Deficiency Anemia in Antenatal Women: A Case Control Study in a Tertiary Care Hospital in New Delhi

Possible Association of Female-Pattern Hair Loss with Alteration in Serum 25-Hydroxyvitamin D Levels

Contact Info

Product

Resources

About