Serum Vitamin D Levels and Risk of Liver Cancer: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies

Zhang, Yonggui; Jiang, Xuefeng; Li, Xiangjun; Găman, Mihnea‐Alexandru; Kord‐Varkaneh, Hamed; Rahmani, Jamal; Salehi‐Sahlabadi, Ammar; Day, Andrew S.; Xu, Yan

doi:10.1080/01635581.2020.1797127

Cited by 43 publications

(30 citation statements)

References 50 publications

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“…The authors suggested that in low dose, antioxidants may improve liver function and in high dose, substance-specific adverse effect was detected [15]. Similar findings associated with supplementation of another vitamin which is associated with antioxidative action (vitamin D) were reported by Zhang et al [43]. Authors postulated that the relationship between serum vitamin D and the risk of liver cancer could be inverse.…”

Section: Vitamin C Concentration and Plasma Pro-/antioxidant Capacitymentioning

confidence: 54%

Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women

Żychowska

Grzybkowska

Wiech

et al. 2020

IJMS

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Physical training and antioxidant supplementation may influence iron metabolism through reduced oxidative stress and subsequent lowering of mRNA levels of genes that are easily induced by this stress, including those responsible for iron homeostasis. Fifteen elderly women participated in our 12-week experiment, involving six weeks of training without supplementation and six weeks of training supported by oral supplementation of 1000 mg of vitamin C daily. The participants were divided into two groups (n = 7 in group 1 and n = 8 in group 2). In group 1, we applied vitamin C supplementation in the first six weeks of training, while in group 2 during the remaining six weeks of training. In both phases, the health-related training occurred three times per week. Training accompanied by vitamin C supplementation did not affect prooxidative/antioxidative balance but significantly decreased ferritin heavy chain (FTH) and ferritin light chain (FTL) mRNA in leukocytes (for FTH mRNA from 2^64.24 to 2^11.06, p = 0.03 in group 1 and from 2^60.54 to 2^16.03, p = 0.01 in group 2, for FTL mRNA from 2^20.22 to 2^4.53, p = 0.01 in group 2). We concluded that vitamin C supplementation might have caused a decrease in gene expression of two important antioxidative genes (FTH, FTL) and had no effect on plasma prooxidative/antioxidative balance.

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Section: Vitamin C Concentration and Plasma Pro-/antioxidant Capacitymentioning

confidence: 54%

Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women

Żychowska

Grzybkowska

Wiech

et al. 2020

IJMS

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“…Recent work by Zhang et al has established that Vitamin D deficiency or insufficiency have also been linked to liver cancer. [ 2 ] Additional, virus replication, liver function and fibrosis, and even interleukin 28B polymorphisms are associated with risk of HCC. [ 3 – 6 ] Among these, DM was of great concern recently.…”

Section: Introductionmentioning

confidence: 99%

Diabetes mellitus affects long-term survival in hepatitis B virus-related hepatocellular carcinoma patients

Zhang

Xiang

et al. 2021

Medicine

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Diabetes mellitus (DM) increases the risk of developing hepatocellular carcinoma (HCC), and how DM affects the prognosis of HCC have not been elucidated. The aim of this study was to compare clinicopathological characteristics and survival between hepatitis B virus (HBV)-related HCC patients with and without DM and to determine risk factors for overall survival after hepatectomy. Among 474 patients with HBV-related HCC, 119 patients had DM. Patients were divided into the diabetic group and nondiabetic group. The short-term and long-term outcomes were evaluated by using propensity score matching analysis. After 1:2 propensity score matching, there were 107 patients in diabetic group, 214 patients in nondiabetic group. The proportion of vessels invasion were higher in diabetic group. The overall survival rate in the diabetic group was 44.7% at 3 years, which was lower than that in the nondiabetic group (56.1%, P = .025). The multivariate analysis indicated that fasting blood glucose >7.0, capsular invasion, microvascular invasion and satellite were independent risk factor of poor prognosis in HCC. DM dose affect the recurrence-free survival and overall survival in HBV-related HCC patients after hepatectomy. One of the more significant findings to emerge from this study is that DM induced higher proportion of major vessel invasion in HCC patients implied unfavorable prognosis.

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“… 10 Another chronic liver disease which has been associated with vitamin D deficiency is hepatocellular carcinoma. 29 However, similarly to vitamin D and NAFLD, this remains controversial and further research is necessary. We intend to explore this possible association in our population in future studies.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity

Borges‐Canha¹,

Neves²,

Mendonça³

et al. 2021

DMSO

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Purpose We aimed to evaluate the association between vitamin D status and hepatic function parameters and scores: Fatty Liver Index (FLI, predictor of hepatic steatosis) and BARD (BMI, AST/ALT ratio and DM, predictor of hepatic fibrosis) in patients with morbid obesity. Patients and Methods Cross-sectional study including patients with morbid obesity followed in our centre between January 2010 and July 2018. Patients with missing vitamin D levels or hepatic profile parameters were excluded. We divided the population according to two cut-offs of vitamin D levels (12ng/mL and 20ng/mL). Results The included population (n=1124) had an average age of 43.3±10.7 years and 84.3% were female. Seventy-point eight percent of the population had vitamin D levels lower than 20ng/mL and 34.8% lower than 12ng/dL. Patients with lower vitamin D levels (<12ng/mL) had higher BMI, hip and waist circumferences and higher prevalence of hypertension. Higher FLI scores [OR= 0.77 (0.07), p<0.01] and ALP levels [β= −0.03 (−0.06, −0.01), p<0.01] associated to lower vitamin D levels. Conclusion Vitamin D deficiency is associated with a higher risk of hepatic steatosis in individuals with morbid obesity. Correction of vitamin D deficiency may have a beneficial role in the management of NAFLD in patients with morbid obesity.

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Serum Vitamin D Levels and Risk of Liver Cancer: A Systematic Review and Dose-Response Meta-Analysis of Cohort Studies

Cited by 43 publications

References 50 publications

Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women

Exercise Training and Vitamin C Supplementation Affects Ferritin mRNA in Leukocytes without Affecting Prooxidative/Antioxidative Balance in Elderly Women

Diabetes mellitus affects long-term survival in hepatitis B virus-related hepatocellular carcinoma patients

The Impact of Vitamin D in Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study in Patients with Morbid Obesity

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