Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

Hajhashemy, Zahra; Lotfi, Keyhan; Heidari, Zahra; Saneei, Parvane

doi:10.3389/fnut.2022.806459

Cited by 6 publications

(1 citation statement)

References 51 publications

(113 reference statements)

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“…We also found that for every 1 cm increase in waist circumference, the risk of VDD and VDI increased by 1.4% (OR: 1.014 (1.012-1.016)). This is consistent with the result of a systematic review by Hajhashemy et al, which showed serum vitamin D level was inversely associated with risk of abdominal obesity in children and adolescents, in a dose-response manner [41].…”

Section: Discussionsupporting

confidence: 92%

Vitamin D Status for Chinese Children and Adolescents in CNNHS 2016–2017

Jiang

et al. 2022

Nutrients

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Vitamin D is very important in maintaining children’s bone health because of its regulatory role in calcium and phosphate metabolism. To better understand vitamin D status and related risk factors of children and adolescents in China, this study analyzed the 25-hydroxyvitamin-D (25(OH)D) concentration of children and adolescents aged 6–17 years in China and assessed the risk factors of vitamin D deficiency and insufficiency. We analyzed the data of 25(OH)D concentration collected from the China National Nutrition and Health Survey of Children and Lactating Mothers in 2016–2017 (CNNHS 2016–2017). The age, sex, region type, ethnicities, season, weight and height were recorded, measured by unified questionnaire, equipment and standards. The concentration of 25(OH)D was detected by LC-MS/MS. A total of 64,391 participants from the cross-sectional study of CNNHS in 2016–2017 were included in this study. The median serum 25(OH)D concentration was 17.70 (13.20–22.68) ng/mL, 18.70 (14.10–23.80) ng/mL in boys and 16.60 (12.40–21.40) ng/mL in girls. The total prevalence rate of vitamin D deficiency and insufficiency was 65.98% when the cut-off was 20 ng/mL, 60.42% for boys and 71.99% for girls. According to the results of logistic regression analysis, girls aged above 12 y, living in midlands and northern regions, in spring and winter seasons and with abdominal obesity will have a significantly increased risk of vitamin D deficiency and insufficiency among Chinese children and adolescents. The results showed that vitamin D deficiency and insufficiency are very common among children and adolescents aged 6–17 y in China. They should be encouraged to have more effective sunlight exposure, increased intake of vitamin D from food or supplements in their diet, especially for those aged above 12 y, living in the northern or midlands areas, in spring and winter, and abdominally obese.

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Section: Discussionsupporting

confidence: 92%

Vitamin D Status for Chinese Children and Adolescents in CNNHS 2016–2017

Jiang

et al. 2022

Nutrients

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Treatment of vitamin D deficiency in children

Fischer,

Johnson,

Leopold

et al. 2023

Expert Review of Endocrinology & Metabolism

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Serum 25-Hydroxyvitamin D Is Associated With Prediabetes, Type 2 Diabetes Mellitus, and Insulin Resistance in Children: A Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies

Hajhashemy,

Ziaei,

Askari

et al. 2024

Nutrition Reviews

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Context Although several investigations have been conducted on the association between serum vitamin D levels and prediabetes and type 2 diabetes mellitus (T2DM) in children and adolescents, their findings are inconsistent. Objective We conducted a systematic review and dose-response meta-analysis to summarize this subject. Data Sources The electronic databases of ISI Web of Science, Scopus, PubMed, and motor engineering of Google Scholar were comprehensively searched up to May 2023. Data Extraction Epidemiologic studies that investigated the risk of hyperglycemia and insulin resistance in relation to serum 25-hydroxy vitamin D levels in children and adolescents were included. Data Analysis Twenty-two investigations, with a total of 38 622 participants, were systematically reviewed. Meta-analysis of 15 studies (n = 32 720 participants) showed that participants with the highest serum vitamin D levels had 42% lower risk of hyperglycemia, compared with those in the lowest category of serum vitamin D levels (relative risk [RR] = 0.58; 95%CI, 0.48, 0.71). Moreover, pooling 8 studies (n = 10 465 participants) illustrated that highest serum vitamin D level was associated with a 44% lower risk of insulin resistance compared with the lowest serum vitamin D level (RR = 0.56; 95%CI, 0.37, 0.83). Based on linear dose-response analysis, each 10 nmol/L increment in serum 25-hydroxy vitamin D was associated with a 6% decreased risk of hyperglycemia and insulin resistance in children. Furthermore, nonlinear dose-response analysis revealed that increasing serum vitamin D concentration from 40 nmol/L to sufficient values (>50 nmol/L) was associated with a decreasing trend in risk of hyperglycemia and insulin resistance. Conclusion This meta-analysis revealed inverse associations between serum vitamin D levels and hyperglycemia and insulin resistance in children and adolescents, in a dose-response manner. Increasing serum vitamin D concentration from 40 nmol/L to sufficient values (>50 nmol/L) was associated with a decreasing trend in hyperglycemia and insulin resistance risk. Systematic Review Registration: PROSPERO registration no. CRD42023458155.

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Serum Vitamin D Levels in Relation to Abdominal Obesity in Children and Adolescents: A Systematic Review and Dose-Response Meta-Analysis

Cited by 6 publications

References 51 publications

Vitamin D Status for Chinese Children and Adolescents in CNNHS 2016–2017

Vitamin D Status for Chinese Children and Adolescents in CNNHS 2016–2017

Treatment of vitamin D deficiency in children

Serum 25-Hydroxyvitamin D Is Associated With Prediabetes, Type 2 Diabetes Mellitus, and Insulin Resistance in Children: A Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies

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