Serum Vitamins and Heavy Metals in Blood and Urine, and the Correlations among Them in Parkinson’s Disease Patients in China

Fukushima, Tetsuhito; Tan, Xiaodong; Luo, Yun; Kanda, Hideyuki

doi:10.1159/000328253

Cited by 39 publications

(22 citation statements)

References 32 publications

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“…However, information is a bit mixed concerning Fe level in plasma/serum of PD patients, which showed all directions of changes from a decrease [16,23], to no change [10,24,25], and to an increase [26]. In the present study, we found plasma Fe level was only elevated in younger (age ≤55) PD patients and decreased ever since, which somewhat explains the dissimilarity of plasma/serum Fe levels in previous reports when only recruiting limited sample size.…”

Section: Discussionmentioning

confidence: 99%

Assessing Plasma Levels of Selenium, Copper, Iron and Zinc in Patients of Parkinson’s Disease

et al. 2013

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Trace elements have been recognized to play an important role in the development of Parkinson’s disease (PD). However, it is difficult to precisely identify the relationship between these elements and the progression of PD because of an insufficient number of patients. In this study, quantifications of selenium (Se), copper (Cu), iron (Fe) and zinc (Zn) by atomic absorption spectrophotometry were performed in plasma from 238 PD patients and 302 controls recruited from eastern China, which is so far the largest cohort of PD patients and controls for measuring plasma levels of these elements. We found that plasma Se and Fe concentrations were significantly increased whereas Cu and Zn concentrations decreased in PD patients as compared with controls. Meanwhile, these four elements displayed differential changes with regard to age. Linear and logistic regression analyses revealed that both Fe and Zn were negatively correlated with age in PD patients. Association analysis suggests that lower plasma Se and Fe levels may reduce the risk for PD, whereas lower plasma Zn is probably a PD risk factor. Finally, a model was generated to predict PD patients based on the plasma concentrations of these four trace elements as well as other features such as sex and age, which achieved an accuracy of 80.97±1.34% using 10-fold cross-validation. In summary, our data provide new insights into the roles of Se, Cu, Fe and Zn in PD progression.

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Section: Discussionmentioning

confidence: 99%

Assessing Plasma Levels of Selenium, Copper, Iron and Zinc in Patients of Parkinson’s Disease

et al. 2013

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“…Elevated Cu stimulates ROS generation, mitochondrial dysfunction and DNA damage [15]. Occupational exposure to Cu increases the risk of developing PD, most probably because it can induce α-Syn aggregation [49, 53, 54, 112]. Cu binds with strong affinity to α-Syn, which has multiple metal-binding sites for Cu [9, 66, 150].…”

Section: Metalsmentioning

confidence: 99%

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation

Rokad

Ghaisas

Harischandra

et al. 2017

Brain Research Bulletin

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Protein misfolding and aggregation are key pathological features of many neurodegenerative diseases including Parkinson’s disease (PD) and other forms of human Parkinsonism. PD is a complex and multifaceted disorder whose etiology is not fully understood. However, several lines of evidence support the multiple hit hypothesis that genetic vulnerability and environmental toxicants converge to trigger PD pathology. Alpha-synuclein (α-Syn) aggregation in the brain is an important pathophysiological characteristic of synucleinopathies including PD. Epidemiological and experimental studies have shown that metals and pesticides play a crucial role in α-Syn aggregation leading to the onset of various neurodegenerative diseases including PD. In this review, we will emphasize key findings of several epidemiological as well as experimental studies of metal- and pesticide-induced α-Syn aggregation and neurodegeneration. We will also discuss other factors such as traumatic brain injury and oxidative insult in the context of α-Syn-related neurodegenerative processes.

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“…Thus, patients with PD have been reported to show elevated levels of manganese and zinc in serum and cerebrospinal fluid [53–55], and manganese and zinc exposure are significant environmental risk factors for PD [56, 57]. ATP13A2 helps protect cells from this toxicity by regulating the homeostasis of manganese and zinc in neurons [41, 44, 58, 59].…”

Section: Physiological Role Of Atp13a2 and Link To Pdmentioning

confidence: 99%

Mutations in theATP13A2Gene and Parkinsonism: A Preliminary Review

Yang

2014

BioMed Research International

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Parkinson's disease (PD) is a major neurodegenerative disorder for which the etiology and pathogenesis remain as elusive as for Alzheimer's disease. PD appears to be caused by genetic and environmental factors, and pedigree and cohort studies have identified numerous susceptibility genes and loci related to PD. Autosomal recessive mutations in the genes Parkin, Pink1, DJ-1, ATP13A2, PLA2G6, and FBXO7 have been linked to PD susceptibility. Such mutations in ATP13A2, also named PARK9, were first identified in 2006 in a Chilean family and are associated with a juvenile-onset, levodopa-responsive type of Parkinsonism called Kufor-Rakeb syndrome (KRS). KRS involves pyramidal degeneration, supranuclear palsy, and cognitive impairment. Here we review current knowledge about the ATP13A2 gene, clinical characteristics of patients with PD-associated ATP13A2 mutations, and models of how the ATP13A2 protein may help prevent neurodegeneration by inhibiting α-synuclein aggregation and supporting normal lysosomal and mitochondrial function. We also discuss another ATP13A2 mutation that is associated with the family of neurodegenerative disorders called neuronal ceroid lipofuscinoses (NCLs), and we propose a single pathway whereby ATP13A2 mutations may contribute to NCLs and Parkinsonism. Finally, we highlight how studies of mutations in this gene may provide new insights into PD pathogenesis and identify potential therapeutic targets.

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Serum Vitamins and Heavy Metals in Blood and Urine, and the Correlations among Them in Parkinson’s Disease Patients in China

Cited by 39 publications

References 32 publications

Assessing Plasma Levels of Selenium, Copper, Iron and Zinc in Patients of Parkinson’s Disease

Assessing Plasma Levels of Selenium, Copper, Iron and Zinc in Patients of Parkinson’s Disease

Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation

Mutations in theATP13A2Gene and Parkinsonism: A Preliminary Review

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