Serum Vitamins and Homocysteine Levels in Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Balandeh, Ebrahim; Karimian, Mohammad; Behjati, Mohaddeseh; Mohammadi, Amir Hossein

doi:10.1159/000514075

Cited by 21 publications

(16 citation statements)

References 71 publications

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“…Some case control studies (33)(34)(35)(36)(37)(38)(39)(40) and a meta-analysis (41) concentrated on the relationship between OCD and MDA. In contrast with our study, Ranjekar et al observed no signi cant differences in serum levels of lipid peroxidation markers between patients with schizophrenic and healthy control (42) A meta-analysis found an inverse association between vitamin E blood levels and OCD (44). In the present study, serum GSH and TAC levels were not signi cantly different between two groups.…”

Section: Discussioncontrasting

confidence: 99%

The oxidative status and Na + /K + -ATPase activity in obsessive-compulsive disorder: a case control study

Mohammadi

Balandeh

Hasani

et al. 2022

Preprint

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Background: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including MDA levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E) and Na+/K+-ATPase activity in patients with the mentioned disorder vs. healthy controls. Method: 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and 39 volunteers’ healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorimetric method. Serum TAC level, serum GSH level and Na+/K+-ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by Reversed-phase high-performance liquid chromatography (RP-HPLC). Result: There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.001) and vitamin E (p=0.024) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na+-K+ ATPase in RBC membrane of OCD patients vs. controls (p<0.0001). Conclusion: Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamin A and E, and lower activity of membrane Na+-K+ ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD.

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Section: Discussioncontrasting

confidence: 99%

The oxidative status and Na + /K + -ATPase activity in obsessive-compulsive disorder: a case control study

Mohammadi

Balandeh

Hasani

et al. 2022

Preprint

Self Cite

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“…Also, Ersan et al (34) and Shohag et al (35) observed a signi cant decreased level of vitamin E in serum of OCD patients, but Shohag et al did not observe any signi cant difference regarding serum vitamin A levels between OCD and healthy controls. A meta-analysis found an inverse association between vitamin E blood levels and OCD (44). In the present study, serum GSH and TAC levels were not signi cantly different between two groups.…”

Section: Discussioncontrasting

confidence: 55%

The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

Mohammadi

Balandeh

Hasani

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including MDA levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E) and Na+/K+-ATPase activity in patients with the mentioned disorder vs. healthy controls.Method: 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and 39 volunteers’ healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorimetric method. Serum TAC level, serum GSH level and Na+/K+-ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by Reversed-phase high-performance liquid chromatography (RP-HPLC).Result: There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.024) and vitamin E (p=0.001) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na+-K+ ATPase in RBC membrane of OCD patients vs. controls (p<0.0001).Conclusion: Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamin A and E, and lower activity of membrane Na+-K+ ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD.

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“…Our patients with vitamin D and folic acid deficiencies were offered substitution therapy. A noteworthy reduction in vitamin B12 levels as reported in a meta-analysis [57] was not observed in this patient cohort.…”

Section: Probable and Possible Organic Ocd Casescontrasting

confidence: 44%

“…Reduced vitamin D levels have been described in children with OCD [54] or PANDAS [55], although more recent studies have found no significant differences in children with OCD [56]. In a recent meta-analysis of these studies, no association was found between OCD and vitamin D deficiency [57]. Nevertheless, vitamin D may have a disease-modifying effect on OCD [58].…”

Section: Probable and Possible Organic Ocd Casesmentioning

confidence: 96%

Deep clinical phenotyping of patients with obsessive-compulsive disorder: an approach towards detection of organic causes and first results

et al. 2023

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In the revised diagnostic classification systems ICD-11 and DSM-5, secondary, organic forms of obsessive-compulsive disorder (OCD) are implemented as specific nosological entities. Therefore, the aim of this study was to clarify whether a comprehensive screening approach, such as the Freiburg-Diagnostic-Protocol for patients with OCD (FDP-OCD), is beneficial for detecting organic OCD forms. The FDP-OCD includes advanced laboratory tests, an expanded magnetic resonance imaging (MRI) protocol, and electroencephalography (EEG) investigations as well as automated MRI and EEG analyses. Cerebrospinal fluid (CSF), [18F]fluorodeoxyglucose positron emission tomography, and genetic analysis were added for patients with suspected organic OCD. The diagnostic findings of the first 61 consecutive OCD inpatients (32 female and 29 male; mean age: 32.7 ± 12.05 years) analyzed using our protocol were investigated. A probable organic cause was assumed in five patients (8%), which included three patients with autoimmune OCD (one patient with neurolupus and two with specific novel neuronal antibodies in CSF) and two patients with newly diagnosed genetic syndromes (both with matching MRI alterations). In another five patients (8%), possible organic OCD was detected (three autoimmune cases and two genetic cases). Immunological serum abnormalities were identified in the entire patient group, particularly with high rates of decreased “neurovitamin” levels (suboptimal vitamin D in 75% and folic acid in 21%) and increased streptococcal (in 46%) and antinuclear antibodies (ANAs; in 36%). In summary, the FDP-OCD screening led to the detection of probable or possible organic OCD forms in 16% of the patients with mostly autoimmune forms of OCD. The frequent presence of systemic autoantibodies such as ANAs further support the possible influence of autoimmune processes in subgroups of patients with OCD. Further research is needed to identify the prevalence of organic OCD forms and its treatment options.

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Serum Vitamins and Homocysteine Levels in Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis

Cited by 21 publications

References 71 publications

The oxidative status and Na + /K + -ATPase activity in obsessive-compulsive disorder: a case control study

The oxidative status and Na + /K + -ATPase activity in obsessive-compulsive disorder: a case control study

The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study

Deep clinical phenotyping of patients with obsessive-compulsive disorder: an approach towards detection of organic causes and first results

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