Serum zinc and copper in hyperlipoproteinemia

G, Uza; Gabor, Silvia; Kovats, Agotha; Vlaicu, R; Cucuianu, M

doi:10.1007/bf02917455

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…Many studies from animal models to human clinical data reported that plasma Cu levels are significantly elevated along with hypercholesterolemia in atherosclerotic subjects [ 140 , 141 ]. Two cross-sectional clinical studies with apparently healthy subjects showed that serum Cu was inversely associated with low-density lipoprotein cholesterol (LDL-C), suggesting that a higher or adequate serum Cu level is linked to a better lipid metabolic state [ 210 ].…”

Section: Disturbance Of Cu Homeostasis In Atherosclerosismentioning

confidence: 99%

Reversal of atherosclerosis by restoration of vascular copper homeostasis

Zuo,

Ding,

Zhang

et al. 2024

Exp. Biol. Med.

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Atherosclerosis has traditionally been considered as a disorder characterized by the accumulation of cholesterol and thrombotic materials within the arterial wall. However, it is now understood to be a complex inflammatory disease involving multiple factors. Central to the pathogenesis of atherosclerosis are the interactions among monocytes, macrophages, and neutrophils, which play pivotal roles in the initiation, progression, and destabilization of atherosclerotic lesions. Recent advances in our understanding of atherosclerosis pathogenesis, coupled with results obtained from experimental interventions, lead us to propose the hypothesis that atherosclerosis may be reversible. This paper outlines the evolution of this hypothesis and presents corroborating evidence that supports the potential for atherosclerosis regression through the restoration of vascular copper homeostasis. We posit that these insights may pave the way for innovative therapeutic approaches aimed at the reversal of atherosclerosis.

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Section: Disturbance Of Cu Homeostasis In Atherosclerosismentioning

confidence: 99%

Reversal of atherosclerosis by restoration of vascular copper homeostasis

Zuo,

Ding,

Zhang

et al. 2024

Exp. Biol. Med.

View full text Add to dashboard Cite

show abstract

“…14 Many studies from animal models to human clinical data found that plasma copper levels are significantly elevated along with hypercholesterolemia in atherosclerotic subjects. 15,16 Copper ions catalyze oxidative modification of LDL in vitro 17,18 and there are also reports on copper participation in the oxidation of LDL in vivo. 19,20 The increase in plasma copper from high-cholesterol feeding would promote oxidative modification of LDL, thus promoting atherosclerosis.…”

Section: Impact Statementmentioning

confidence: 99%

Atherosclerotic lesion-specific copper delivery suppresses atherosclerosis in high-cholesterol-fed rabbits

Wang

et al. 2021

Exp Biol Med (Maywood)

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Dietary cholesterol supplements cause hypercholesterolemia and atherosclerosis along with a reduction of copper concentrations in the atherosclerotic wall in animal models. This study was to determine if target-specific copper delivery to the copper-deficient atherosclerotic wall can block the pathogenesis of atherosclerosis. Male New Zealand white rabbits, 10-weeks-old and averaged 2.0 kg, were fed a diet containing 1% (w/w) cholesterol or the same diet without cholesterol as control. Twelve weeks after the feeding, the animals were injected with copper-albumin microbubbles and subjected to ultrasound sonication specifically directed at the atherosclerotic lesions (Cu-MB-US) for target-specific copper delivery, twice a week for four weeks. This regiment was repeated 3 times with a gap of two weeks in between. Two weeks after the last treatment, the animals were harvested for analyses of serum and aortic pathological changes. Compared to controls, rabbits fed cholesterol-rich diet developed atherosclerotic lesion with a reduction in copper concentrations in the lesion tissue. Cu-MB-US treatment significantly increased copper concentrations in the lesion, and reduced the size of the lesion. Furthermore, copper repletion reduced the number of apoptotic cells as well as the content of cholesterol and phospholipids in the atherosclerotic lesion without a disturbance of the stability of the lesion. The results thus demonstrate that target-specific copper supplementation suppresses the progression of atherosclerosis at least in part through preventing endothelial cell death, thus reducing lipid infiltration in the atherosclerotic lesion.

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Serum zinc and copper in patients with atherosclerosis andThromboangiitis obliterans

G¹,

Vlaicu²

1989

Biol Trace Elem Res

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The serum concentration of Zn and Cu were determined in 126 controls and 160 patients with atherosclerosis obliterans (AO) and 53 patients with thromboangiitis obliterans (TO). The concentration of serum Zn decreases with age both in controls and patients with AO in all the evolutive stages of the disease. In patients with TO, the concentration of serum Zn shows no correlation with age. The significantly lower values of serum Zn in controls and patients with AO over 61 yr than those below this age is attributed to the decreased Zn supply, especially to some individual cellular abnormalities. The values of serum Cu are higher in patients with AO and TO than in controls irrespective of the evolutive stage of the disease. This was related to cigarette smoking and inflammation. The Zn/Cu ratio in the serum is below 1 in patients with AO and TO and in controls over 61-yr-old. The pathogenetic role of this ratio in atherosclerosis and inflammation still remains a controversial question.

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Serum zinc and copper in hyperlipoproteinemia

Cited by 9 publications

References 8 publications

Reversal of atherosclerosis by restoration of vascular copper homeostasis

Reversal of atherosclerosis by restoration of vascular copper homeostasis

Atherosclerotic lesion-specific copper delivery suppresses atherosclerosis in high-cholesterol-fed rabbits

Serum zinc and copper in patients with atherosclerosis andThromboangiitis obliterans

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