Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan

Ishihara, Jun; Arai, Katsuhiro; Kudo, Toshifumi; Nambu, Ryusuke; Tajiri, Hitoshi; Aomatsu, Tomoki; Abe, Naoki; Kakiuchi, Toshihiko; Hashimoto, Kunio; Sogo, Tsuyoshi; Takahashi, Michiko; Etani, Yuri; Yasuda, Ryosuke; Sakaguchi, Hirotaka; Konishi, Ken-Ichiro; Obara, Hitoshi; Kakuma, Tatsuyuki; Yamashita, Yushiro; Mizuochi, Tatsuki

doi:10.1007/s10620-021-07078-z

Cited by 13 publications

(15 citation statements)

References 33 publications

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“…Moreover, zinc is important in immune function. Absorption of zinc was taken in length of the small intestine but the transport procedure isn't well described [17]. Like our results, in IBD patients, a number of studies have reported low plasma zinc levels in IBD patients [12,18,19].…”

Section: Discussionmentioning

confidence: 51%

Evaluation of plasma levels of iron, copper, zinc, selenium and some transporter proteins in patients with IBD compared to IBS

shokri

Kopi

Alhooei

et al. 2022

Preprint

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Background and purpose: Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are both chronic gastrointestinal diseases with different pathophysiology but similar symptoms. In this study, we intend to investigate the pattern of changes in plasma levels of Fe, Zn, Se, Cu and ferritin, transferrin and ceruloplasmin, as well as oxidative and antioxidant capacity in IBD patients compared to IBS and the healthy group.Methods: This case-control study was performed on three groups of 30 patients with IBD and IBS and healthy individuals. ELISA method was used to measure the levels of ferritin and total oxidant, atomic absorption method for selenium and copper, and spectrophotometry for iron, zinc, transferrin and ceruloplasmin.Results: According to the results of this study, we showed that the levels of oxidative stress and transferrin, selenium, and zinc in men with IBD compared to IBS and control, showed a significant difference while in women no significant changes were observed in other factors except transferrin and Zn. There was also a significant increase in MDA, a decrease in TAC and a decrease in zinc and transferrin in the entire population with IBD. Also, lower levels of Fe and Se were observed in IBD patients compared to IBS and the healthy group. However, this difference was not statistically significant.Conclusion: The results of this study showed that the study of some trace elements may help us to find a more effective and easier method in diagnosing and differentiating people with IBD and IBS.

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Section: Discussionmentioning

confidence: 51%

Evaluation of plasma levels of iron, copper, zinc, selenium and some transporter proteins in patients with IBD compared to IBS

shokri

Kopi

Alhooei

et al. 2022

Preprint

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“…Interestingly, CD patients on total parenteral nutrition can easily develop zinc deficiency and present with acrodermatitis enteropathica and impaired vision 94 . Children with CD often show stunted growth, decreased taste sensation, visual acuity, and immune function 95 …”

Section: Resultsmentioning

confidence: 99%

“… 94 Children with CD often show stunted growth, decreased taste sensation, visual acuity, and immune function. 95 …”

Section: Resultsmentioning

confidence: 99%

“…94 Children with CD often show stunted growth, decreased taste sensation, visual acuity, and immune function. 95 In vitro studies on human intestinal CACO-2/T7 cell line showed how zinc deprivation is able to increase apoptosis, compromising tight junctions integrity, and intestinal permeability. 96 Therefore, zinc supplementation seems to decrease trans-mucosal leak in Crohn's patients.…”

Section: Zinc and Inflammatory Bowel Diseasesmentioning

confidence: 99%

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Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

et al. 2022

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Microelements represent an emerging resource for medicine and its preventive branch. Zinc is the second most abundant element in our organism with peculiar physiologic functions and pathophysiologic implications in systemic and gastrointestinal (GI) diseases. It interacts very often with gut microbiota (GM) and can affect natural course of GI diseases through a bidirectional relationship with intestinal bugs. We aimed to review literature data regarding zinc chemistry, role in health, and GI diseases in man with a special focus on its interaction with GM. We conducted a search on the main medical databases for original articles, reviews, meta‐analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: zinc, microelements, gut microbiota, gut health, and COVID‐19. Zinc has a rapid and simple metabolism and limited storage within our body. Its efficacy on immune system modulation reflects on improved response to pathogens, reduced inflammatory response, and improved atopic/allergic reactions. Zinc is also involved in cell cycle regulation (namely, apoptosis) with potential anti‐cancerogenic effects. All these effects are in a “symbiotic” relationship with GM. Finally, zinc shows preliminary viral antireplicative effects. Zinc seems to gain more and more evidences on its efficacy in allergic, atopic and infectious diseases treatment, and prevention. COVID‐19 can be the booster for research on future applications of zinc as perfect “postbiotic” in medicine.

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“…Then, 37 were excluded for failure to meet the characteristics of the approach or the review goal. After reviewing the full text of the remaining 38 records, only 9 met the inclusion criteria and were included in the meta-analysis [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) flow chart illustrating the number of studies at each stage of the review is shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

et al. 2022

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Malabsorptive disorders are closely associated with micronutrient deficiencies. In inflammatory bowel disease (IBD), trace element deficiencies pose a clinical burden from disease onset throughout its course, contributing to morbidity and poor quality of life. We aimed to conduct a systematic review and meta-analysis of the prevalence of zinc deficiency in IBD. Literature screening was performed on six electronic databases until 1 May 2022. Two independent investigators assessed the 152 retrieved articles for inclusion criteria, met by only nine, that included 17 prevalence entries for Crohn’s disease (CD) (n = 9) and ulcerative colitis (UC) (n = 8). No exclusion criteria were applied to language, deficiency cut-offs, population age, general health status, country, or study setting (cohort or cross-sectional). The prevalence of zinc deficiency in blood was scored positive if due to a single disease, not cumulative factors. Zinc deficiency prevalence across selected studies showed higher values in CD than in UC. Pooled analyses by the IBD subgroup showed a total population of 1677 with CD, for an overall mean zinc deficiency prevalence of 54% and 95% confidence intervals (CI) ranging from 0.51 to 0.56, versus 41% (95%CI 0.38–0.45) in the UC population (n = 806). The overall prevalence at meta-analysis was estimated at 50% (95%CI 0.48–0.52), but with high heterogeneity, I2 = 96%. The funnel plot analysis failed to show any evidence of publication bias. The risk of bias across selected studies was moderate to low. In IBD contexts, one of two patients suffers from zinc deficiency. Mismanagement of micronutrient deficiencies plays a role in inflammation trajectories and related cross-pathways. Clinicians in the field are advised to list zinc among trace elements to be monitored in serum.

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Serum Zinc and Selenium in Children with Inflammatory Bowel Disease: A Multicenter Study in Japan

Cited by 13 publications

References 33 publications

Evaluation of plasma levels of iron, copper, zinc, selenium and some transporter proteins in patients with IBD compared to IBS

Evaluation of plasma levels of iron, copper, zinc, selenium and some transporter proteins in patients with IBD compared to IBS

Zinc and gut microbiota in health and gastrointestinal disease under the COVID‐19 suggestion

Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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