Serum Zinc and Vitamin E Concentrations in
Handicapped Children Treated with Anticonvulsants

Higashi, Akimasa; Ikeda, Tetsuo; Matsukura, Makoto; Matsuda, Ichiro

doi:10.1159/000480986

Cited by 18 publications

(10 citation statements)

References 12 publications

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“…Clinical studies in children have shown reduced plasma levels of Vitamin E in seizure patients receiving AEDs but not in patients prior to AEDs or in age-related controls (Ogunmekan, 1978a(Ogunmekan, ,b, 1979a(Ogunmekan, ,b, 1985Higashi et al, 1980;Nagaura et al, 1985).…”

mentioning

confidence: 99%

A Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopheryl Acetate (Vitamin E), as Add‐On Therapy, for Epilepsy in Children

Ogunmekan

Hwang

1989

Epilepsia

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In 24 epileptic children refractory to antiepileptic drugs (AEDs) with generalized tonic-clonic and other types of seizures, addition of D-alpha-tocopheryl acetate (Vitamin E 400 IU/day) to existing AEDs was accompanied by a significant reduction of seizures in 10 of 12 cases. This was significantly different from controls given placebo (0 of 12, p less than 0.05). This result did not appear to be due to the effects of changes in the plasma levels of the comedication. There were no adverse side effects. The Vitamin E levels steadily increased in the responders in the trial phase but this did not occur in two clinically noncompliant subjects or in 12 patients receiving placebo. No other clinically significant alterations in hematologic or biochemical test results were observed. No treatment-related changes in plasma concentration of concomitant AEDs were noted. These findings justify further clinical controlled trials of Vitamin E as adjunctive therapy for childhood epilepsy intractable to the usual antiepileptic therapy.

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mentioning

confidence: 99%

A Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopheryl Acetate (Vitamin E), as Add‐On Therapy, for Epilepsy in Children

Ogunmekan

Hwang

1989

Epilepsia

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“…In contrast to these findings, Barbeau and Donaldson [37] reported lower Zn concentrations in persons with epilepsy. In another study, long-term use of anticonvulsants resulted in zinc deficiency in some but not all patients [38]. Schott and Delves [39] showed normal zinc concentrations among untreated, treated and clinically intoxicated patients.…”

Section: Discussionmentioning

confidence: 92%

Valproic Acid Modulates Superoxide Dismutase, Uric Acid-Independent FRAP and Zinc in Blood of Adult Epileptic Patients

Płonka-Półtorak¹,

Zagrodzki

Chłopicka

et al. 2011

Biol Trace Elem Res

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We aimed to evaluate changes in antioxidant status in blood during valproate (VPA) monotherapy of adult patients with epilepsy. Antioxidant enzymes [plasma superoxide dismutase (pSOD), erythrocyte superoxide dismutase (eSOD)] and non-enzymatic indices [concentration of trace elements in serum: selenium, copper, zinc (sZn) and uric acid (UA), as well as the ferric reducing ability of plasma (FRAP) and UA-independent FRAP (UAiFRAP)] were evaluated in 21 adult patients with epilepsy and 21 healthy controls. Significant differences between the study group and controls were found for pSOD (p = 0.002) and UAiFRAP (p = 0.003). pSOD was higher, whilst UAiFRAP was lower in patients compared to controls. The activity of eSOD was higher in patients treated with VPA for a longer period (7-14 years) in comparison to controls (p = 0.001) and patients with a short period of VPA treatment (p < 0.001). Patients with uncontrolled epilepsy exhibited higher sZn than seizure-free patients (p = 0.041). Standard diet and moderate use of alcohol and/or nicotine did not exert significant effects on redox balance. We conclude that the antioxidant status of epileptic patients is modified by valproate monotherapy. The frequency of seizures and duration of VPA therapy are associated with changes of oxidative/antioxidative balance. The most sensitive and relevant parameters for antioxidative defence mechanism are pSOD, UAiFRAP and sZn.

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“…Vitamin E deficiency has been reported in patients with epilepsy, though its clinical significance remains uncertain. This deficiency has been attributed to antiepileptic therapy (Higashi et al, 1980)…”

Section: Vitamins and Other Nutrients In Patients With Epilepsy (Tablmentioning

confidence: 99%

Nutritional supplements, foods, and epilepsy: Is there a relationship?

2008

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Summary Anecdotal reports suggest that certain foods and dietary contents might influence the occurrence of seizures. However, the existing data are scanty and sometimes controversial. Some studies have found that the supplementation with individual nutrients reduced seizure frequency or improved other aspects of health in patients with epilepsy, while other studies have failed to confirm those findings. Nutrient supplementation may be necessary to prevent or reverse the effects of certain deficiencies that frequently result from the use of antiepileptic drugs (AEDs). However, the potential benefits of nutrient supplementation in patients with epilepsy must be weighed against reports that large doses of certain nutrients can interfere with the action of some AEDs. This paper reviews dietary and nutritional considerations in patients with epilepsy and also the relationship between foods, dietary elements, and seizures.

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Serum Zinc and Vitamin E Concentrations in Handicapped Children Treated with Anticonvulsants

Cited by 18 publications

References 12 publications

A Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopheryl Acetate (Vitamin E), as Add‐On Therapy, for Epilepsy in Children

A Randomized, Double‐Blind, Placebo‐Controlled, Clinical Trial of D‐α‐Tocopheryl Acetate (Vitamin E), as Add‐On Therapy, for Epilepsy in Children

Valproic Acid Modulates Superoxide Dismutase, Uric Acid-Independent FRAP and Zinc in Blood of Adult Epileptic Patients

Nutritional supplements, foods, and epilepsy: Is there a relationship?

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