Serum zinc concentration and risk of adverse outcomes to in vitro fertilization and embryo transfer: A prospective cohort study in northern China

The Impact of Essential Trace Elements on Ovarian Response and Reproductive Outcomes following Single Euploid Embryo Transfer

“…Cereals and meat are the main zinc sources [ 4 ]. Our patients had zinc concentrations similar to those described in other studies using IVF patients [ 11 , 13 ]. Although the FF concentrations were lower than previously reported [ 17 , 18 ], this discrepancy is likely due to copper and zinc concentrations being lower in women undergoing IVF treatment than in the general population [ 8 , 9 , 10 ].…”

“…Other groups have evaluated how trace elements in different biofluids from women undergoing IVF treatments impact their reproductive outcomes [ 11 , 12 , 13 , 17 , 18 , 19 ], however, these studies were performed in general IVF populations with potentially confounding factors (e.g., aneuploid transfers and the effect of endometrial stimulation hormones), leading to inconsistent findings. Notably, essential trace elements were scarcely investigated in plasma, and, to our knowledge, this is the first report associating lithium (in any biofluid) to reproductive outcomes.…”

“…Few studies have previously evaluated the impact of female essential trace elements in different biofluids on IVF outcomes, with inconsistent findings [ 11 , 12 , 13 ]. Further, these studies have primarily focused on zinc, with limited data to support the roles of other essential trace elements on in vitro fertilization (IVF) outcomes [ 11 , 12 , 13 ].…”

“…Few studies have previously evaluated the impact of female essential trace elements in different biofluids on IVF outcomes, with inconsistent findings [ 11 , 12 , 13 ]. Further, these studies have primarily focused on zinc, with limited data to support the roles of other essential trace elements on in vitro fertilization (IVF) outcomes [ 11 , 12 , 13 ]. Thus, this study aimed to evaluate the impact of multiple essential trace elements, with IVF outcomes, using the concentrations found in the follicular fluid (FF), plasma, and urine of women undergoing intracytoplasmic sperm injection (ICSI) with preimplantation genetic testing for aneuploidies (PGT-A) and single frozen embryo transfer (SET/FET).…”

Higher Concentrations of Essential Trace Elements in Women Undergoing IVF May Be Associated with Poor Reproductive Outcomes Following Single Euploid Embryo Transfer

“…In these cases, supplementation may help mitigate associated conditions and improve reproductive outcomes [5,7], but the pathogenesis of reproductive disorders driven by irregular trace element concentrations remains unclear. The reported associations between essential trace element levels and assisted reproductive treatment (ART) outcomes in cohorts of American women undergoing in vitro fertilization (IVF) are inconsistent between studies [9][10][11][12]. These discrepancies may be due to geographical and cultural factors or variable ART methodologies between clinics.…”