Serum zinc levels are associated with obesity and low-density lipoprotein cholesterol in Mexican adults

Hernández‐Mendoza, Héctor; Martínez-Navarro, Israel; Hernández-Ochoa, Edduin; Espinoza-Ruiz, Marisol; Lugo‐Trampe, Ángel; Trujillo-Murillo, Karina del Carmen; López-García, Maximiliano Arahon; Rios-Lugo, María Judith; Chang-Rueda, Consuelo

doi:10.1016/j.jtemb.2022.127002

Cited by 15 publications

(4 citation statements)

References 38 publications

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“…Liu et al also found that overexpression of the Zn-α2-glycoprotein gene significantly reduced mice's body weight and adipose tissue mass (53) . In a study about Mexican adults, Héctor Hernández-Mendoza et al found a negative association between plasma Zn levels and obesity (54) . Several other studies similarly found a negative association between plasma Zn levels and waist circumference and/or BMI (55)(56)(57) , which is consistent with our findings that plasma Zn was negatively associated with general obesity.…”

Section: Discussionmentioning

confidence: 95%

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Liu

Huang

et al. 2023

Br J Nutr

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Trace elements may play an important role in obesity. This study aimed to assess the plasma and dietary intake levels of four trace elements, manganese, copper, zinc and selenium in a rural Chinese population and analyse the relationship between trace elements and obesity. A cross-sectional study involving 2587 participants was conducted. Logistic regression models were used to analyse the association between trace elements and obesity; Restricted cubic spline(RCS) models were used to assess the dose-response relationship between trace elements and obesity; The Weighted Quantile Sum(WQS) model was used to examine the potential interaction of four plasma trace elements on obesity. Logistic regression analysis showed that plasma selenium concentrations in the fourth quartile(Q4) exhibited a lower risk of developing obesity than the first quartile(Q1)(central obesity: OR=0.634, P=0.002; general obesity: OR=0.525, P=0.005). Plasma zinc concentration in the third quartile(Q3) showed a lower risk of developing obesity in general obesity compared to the first quartile(Q1)(OR=0.625, P=0.036). In general obesity, the risk of morbidity was 1.727 and 1.923 times higher for the second and third(Q2, Q3) quartiles of dietary manganese intake than for Q1, respectively. RCS indicated an inverse U-shaped correlation between plasma selenium and obesity. WQS revealed the combined effects of four trace elements were negatively associated with central obesity. Plasma zinc and selenium were negatively associated with obesity and dietary manganese was positively associated with obesity. The combined action of the four plasma trace elements had a negative effect on obesity.

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Section: Discussionmentioning

confidence: 95%

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Liu

Huang

et al. 2023

Br J Nutr

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“…Zinc is involved in a variety of physiological processes, and de ciencies of this trace element are associated with metabolic dysfunction and consequent disease. Among Mexican adults, serum Zn levels were negatively associated with BMI and obesity [41]. Studies have associated gut microbiota induced by Zn with autism spectrum disorders, attention de cit hyperactivity disorder, and obesity [42].…”

Section: Discussionmentioning

confidence: 99%

Serum Trace Metallic Element of Copper is Associated with Overweight and Obesity

Yang,

Liu,

Feng

et al. 2024

Preprint

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The relationship between serum trace metallic elements and overweight and obesity is unclear, and few studies have evaluated the relationship between serum trace metal elements and overweight and obesity. Nine serum trace metallic elements of Ca, Cu, Fe, Mg, Mn, Mo, Se, V and Zn were detected in people with obesity and normal adults. Then 1865 adults from 2011–2016 cycles of National Health and Nutrition Examination Survey was included for a large sample analysis. Serum Cu is highly expressed in the people with obesity. The third quartile (Q3) (OR: 1.898, 95% CI: 1.173–3.071, P = 0.012) and fourth quartile (Q4) (OR: 2.047, 95% CI: 1.201–3.489, P = 0.011) of Cu were related to an increased likelihood of people with overweight and obesity. Subgroup analysis showed that high levels of serum Cu (OR: 1.011, 95% CI: 1.004–1.018, P = 0.002) were found may be a risk factor for overweight and obesity in females and in the 20–39 years old (OR: 1.010, 95% CI: 1.002–1.019, P = 0.020). The RCS models detect non-linear relationships between serum trace metallic elements and overweight and obesity. The study provides insights into the relationship between trace metallic elements and overweight and obesity, providing an opportunity for further investigation in this area.

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“…In this context, future studies would be interesting to evaluate if sex hormones mediate the association between Se and cardiometabolic traits. Additionally, the recent report about the sex-specific association between serum zinc and LDL-C levels in a Mexican population [ 67 ], encourage sex-specific analysis for further observational, cohort, and clinical trial studies, to offer better insight into the role of trace elements in the physiopathology and the potential proposal of personalized biomarkers for the early prevention and treatment of metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

et al. 2022

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Selenium (Se) is an essential trace element that by its antioxidant properties has been studied to elucidate its participation in the development of obesity and type 2 diabetes. We evaluated the association between cardiometabolic traits and serum Se levels in a sample of adults from southern Mexico. In 96 nondiabetic individuals, anthropometric data and clinical biochemistry measurements were analyzed. Serum total Se levels were measured with inductively coupled plasma mass spectrometry (ICP-MS). Serum Se level in the whole sample was 10.309 ± 3.031 μg mL−1 and no difference between the women and men was observed (p = 0.09). Additionally, fasting plasma glucose (FPG) was significantly associated with serum Se level (β = −0.07 ± 0.03, p = 0.02, analysis adjusted for age, sex and BMI). Furthermore, sex shows significant interaction with FPG on the serum Se levels (p = 0.01). A follow-up analysis revealed the particular association between FPG and Se levels in women (β = −0.10 ± 0.04, p = 0.01). In conclusion, our data evidenced a women-specific association between FPG and serum Se levels in a sample of adults from southern Mexico.

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Serum zinc levels are associated with obesity and low-density lipoprotein cholesterol in Mexican adults

Cited by 15 publications

References 38 publications

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Association between plasma and dietary trace elements and obesity in a rural Chinese population

Serum Trace Metallic Element of Copper is Associated with Overweight and Obesity

Sex-Specific Association between Fasting Plasma Glucose and Serum Selenium Levels in Adults from Southern Mexico

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