Serum zinc levels in HIV infected children attending the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.

Yarhere, IE; Ugwu, R.N; Eneh, AU

doi:10.4314/njp.v41i2.6

Cited by 6 publications

(8 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zinc deficiency was most prevalent in this study. This is in corroboration with previous studies, where zinc deficiency in HIV-infected children was found to be 54.3% [13], 77.1% [14], and 60% [15], respectively. Earlier reports show that zinc plays an important role in modulating the function of HIV viral enzymes mainly integrase and proteases [10,11].…”

Section: Discussionsupporting

confidence: 93%

“…Contrary to other studies [13][14][15], majority of our study population were in clinical stage 1 and 2, with few (12/100) having stage 3 diseases. Normal immunity (74%), advanced (7%), and severe immunosuppression (5%) was present in our study and was not concordant with previous studies [13][14][15]. Prior studies [14,15] have shown that, with a worsening status in the WHO clinical staging of HIV disease, there was reduction in mean serum zinc levels.…”

Section: Discussioncontrasting

confidence: 85%

“…Normal immunity (74%), advanced (7%), and severe immunosuppression (5%) was present in our study and was not concordant with previous studies [13][14][15]. Prior studies [14,15] have shown that, with a worsening status in the WHO clinical staging of HIV disease, there was reduction in mean serum zinc levels. Yarhere et al [15] had found significant difference in mean serum zinc levels between subjects in stages 1 and 2, and those in stages 3 and 4, with the latter having lower mean levels.…”

Section: Discussionsupporting

confidence: 59%

“…When HIV-infected children on highly active antiretroviral therapy (HAART) and not on HAART were compared, various studies have demonstrated mean serum zinc levels to be higher, with decreased prevalence of zinc deficiency in HIV children on HAART therapy, both these aspects being statistically significant [13][14][15]. Similar results were seen among adult HIV-infected patients [24].…”

Section: Discussionmentioning

confidence: 84%

“…Until recently, very few studies have been globally conducted on micronutrients status of HIV-infected children [13][14][15], with a single study from India [16]. The results obtained from these studies still remain inconclusive, as they are considerably limited by small number of study participants.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Micronutrients status among human immunodeficiency virus-infected children in Southern India

Sivasubramanian¹,

Shenoy²,

Kamath³

et al. 2020

HIV & AIDS Review

View full text Add to dashboard Cite

Introduction: Deficiencies of micronutrients play a role in human immunodeficiency virus (HIV) infection and its severity. Identifying the micronutrient status would guide supplementation, thus altering the disease progression and severity. Material and methods: A cross-sectional hospital-based study was conducted in Southern India on hundred HIV-infected children. Estimation of serum micronutrient levels (zinc, copper, and iron) and comparison of the deficient micronutrients with clinical stages, immunological categories, CD4 counts, and nutritional status was performed. Results: Among 100 HIV-infected children, zinc deficiency was the most common (62%), whereas copper and iron deficiency was present in 2% and 1%, respectively. Mean age of children was 11.20 ± 3.14 years, 52% were girls, 24% were malnourished, 76% were receiving antiretroviral therapy (ART), and four had CD4 counts < 200/mm 2 indicating AIDS. Using Kruskalwallis test, serum iron levels (p = 0.000) and CD4 levels (p = 0.001) were significantly associated with clinical stages, while serum zinc levels (p = 0.043) and CD4 levels (p = 0.000) were significantly associated with various degrees of immune classification. Mean micronutrient levels did not correlate significantly with CD4 counts less than and greater than 350 by unpaired t test. Zinc deficiency did not correlate with clinical staging, immunological classification, nutritional status, and receipt of ART on multiple logistic regression analysis. Conclusion: In HIV-infected children, zinc deficiency was the most common and it did not correlate with clinical staging, immunological classification, nutritional status, and receipt of antiretroviral therapy. Hence, supplementation of zinc would be required along with initiation of ART.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 85%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Micronutrients status among human immunodeficiency virus-infected children in Southern India

Sivasubramanian¹,

Shenoy²,

Kamath³

et al. 2020

HIV & AIDS Review

View full text Add to dashboard Cite

show abstract

Paediatric HIV: Correlation between Serum Zinc Levels and CD4 Percentage on Asymptomatic Nigerian Children Living with HIV

Chukwu

Nduagubam

Ekwochi

2022

Journal of Tropical Pediatrics

View full text Add to dashboard Cite

Objective This study was conducted to determine the relationship between their serum zinc levels and the CD4% in a cohort children living with HIV. Methods One hundred asymptomatic, anti-retroviral Therapy (ART) naïve children living with HIV (participants) aged 5–60 months who were enrolled into the Paediatric HIV clinic of The University of Nigeria Teaching Hospital were recruited in the study over a 10-month period. Blood samples were collected in the morning from non-fasting participants and serum zinc levels were analysed using Atomic Absorption Spectrophotometer. The CD4% was ascertained using the CD4% easy count kit on the Partec® Cyflow Counter machine. Data were analysed using Statistical Package for the Social Sciences version 19. Result The median (IQR) serum zinc level for the participants was 55.5 µg/dl (49.75) while their median (IQR) CD4% was 27.79% (18.67). Males had a median (IQR) CD4% of 24.29% (19.10) which was significantly lower than those of females [32% (20.59) (p = 0.047)]. No significant relationship was found between CD4% and zinc levels among the subjects (r = −0.061, p = 0.557). Conclusion Serum zinc levels of asymptomatic ART naïve children living with HIV have no relationship with their CD4%.

show abstract

Effect of nutrition education on nutritional status and serum zinc level of HIV and AIDS clients: implication for care in resource-limited settings

Ezenwosu

Mbachu

et al. 2022

African Journal of AIDS Research

View full text Add to dashboard Cite

Serum zinc levels in HIV infected children attending the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.

Cited by 6 publications

References 9 publications

Micronutrients status among human immunodeficiency virus-infected children in Southern India

Micronutrients status among human immunodeficiency virus-infected children in Southern India

Paediatric HIV: Correlation between Serum Zinc Levels and CD4 Percentage on Asymptomatic Nigerian Children Living with HIV

Effect of nutrition education on nutritional status and serum zinc level of HIV and AIDS clients: implication for care in resource-limited settings

Contact Info

Product

Resources

About