Serum zinc levels in Iranian patients with acne

Nasiri, Soheila; Ghalamkarpour, Fariba; Yousefi, Maysam; Sadighha, Afshin

doi:10.1111/j.1365-2230.2009.03486.x

Cited by 10 publications

(11 citation statements)

References 5 publications

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“…The present study showed that serum Zn level was lower in acne patients than in healthy male controls, but the difference was not significant. This finding is consistent with that observed by Nasiri et al in 2009 [10] who found insignificant decrease of serum Zn in their Iranian people compared with healthy controls. However, the present…”

Section: Discussionsupporting

confidence: 93%

“…A review reported by Dr. Preston, indicated that lack of zinc is a recipe for acne [21]. Nasiri et al in 2009 concluded from their study that zinc as anti-inflammatory element may play a role in the pathogenesis of acne, and there is a need for further studies [10].…”

Section: Severe Acnementioning

confidence: 99%

“…Recently, Nasiri et al in 2009 indicated that serum zinc levels in 30 Iranian acne patients were lower than that of 35 healthy controls; however, this difference was not significant (P=0.32) [10].…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients

Saleh¹,

Anbar²,

Majid³

2013

J Clin Exp Dermatol Res

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Section: Discussionsupporting

confidence: 93%

Section: Severe Acnementioning

confidence: 99%

See 1 more Smart Citation

Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients

Saleh¹,

Anbar²,

Majid³

2013

J Clin Exp Dermatol Res

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show abstract

“…In spite of the lack of a double blind control, we believe that in light of the overwhelming clinical (2–12,50) and investigative studies (14–35,49,50), zinc especially in picolonate or as in our case methionine bound form (13,51), is a viable option in acne in conjunction with antioxidants (1,36–46).…”

Section: Discussionmentioning

confidence: 85%

“…The various theories proposed for zincs action range form its effect on retinol binding protein (14), increase in the low levels of zinc in acne (15,16), anti‐inflammatory effect (17,18), and its inhibitory effect on the enzyme dihydrotestosterone via type 1 5α‐reductase (19–23) (Table 2).…”

Section: Discussionmentioning

confidence: 99%

An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris

Sardana

Garg

2010

Dermatologic Therapy

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APC is a novel methionine-based zinc complex with antioxidants that has been used in acne as a nutritional supplement. This is based on the proven role of zinc and antioxidants in improving acne, specially the inflammatory lesions. The objectives of this study are to explore the efficacy, safety, and tolerability of APC in acne patients with mild to moderate facial acne vulgaris. In this exploratory trial, 48 patients were treated with oral APC thrice a day for 3 months followed by a 4-week treatmentfree period. At the end of treatment (Week 12), there was a statistically significant improvement in the global acne count (p < 0.05), which began after 8 weeks (p < 0.05). Almost 79% (38/48) of the patients had 80-100% improvement. There was a significant reduction in pustules (8 weeks (p < 0.05) and 12 weeks (p < 0.001)), and papules and closed comedones (8 weeks (p < 0.05) and 12 weeks (p < 0.001)). Only two patients had side effects. The current data indicate that treatment with oral APC thrice daily for 12 weeks in patients with mild to moderate facial acne vulgaris is efficacious and well tolerated. As the onset of action is late, concomitant topical therapy can enhance the results.

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The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population

Ikaraoha

Mbadiwe

Anyanwu

et al. 2016

Biol Trace Elem Res

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Acne vulgaris is a very common skin disorder affecting human beings. There is a paucity of report on the role of heavy metals-lead (Pb) and cadmium (Cd)-globally, and trace metals-zinc (Zn) and copper (Cd)-particularly in Nigeria in the development/severity of acne vulgaris. This study is aimed to determine the blood levels of some heavy metals-cadmium and lead-and trace metals-zinc and copper-in acne vulgaris sufferers in a Nigerian population. Venous blood samples were collected from a total number of 90 non-obese female subjects consisting of 30 mild, 30 moderate and 30 severe acne vulgaris sufferers for blood Cd, Pb, Cu and Zn determination. They were age-matched with 60 females without acne vulgaris who served as the control subjects. Acne sufferers had significantly higher blood Cd and Pb (P = 0.0143 and P = 0.0001 respectively) and non-significantly different blood levels of Cu and Zn (P = 0.910 and P = 0.2140 respectively) compared to controls. There were significant progressive increases in blood levels of Cd and Pb (P = 0.0330 and P = 0.0001 respectively) and non-significant differences in the mean blood level of Cu and Zn (P = 0.1821 and P = 0.2728 respectively) from mild to moderate and severe acne vulgaris sufferers. Increases in blood Cd and Pb may play critical roles in the pathogenesis/severity of acne vulgaris, while Cu and Zn seem to play less significant roles in the development of this disorder in this environment.

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Serum zinc levels in Iranian patients with acne

Cited by 10 publications

References 5 publications

Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients

Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients

An observational study of methionine-bound zinc with antioxidants for mild to moderate acne vulgaris

The Role of Blood Lead, Cadmium, Zinc and Copper in Development and Severity of Acne Vulgaris in a Nigerian Population

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