Serum zonulin and intestinal permeability before and after a gluten-containing meal in both type 1 diabetes and their relatives

Sapone, Anna; Magistris, Laura de; Caravelli, G.; Familiari, V.; Riegler, G.; Zampini, Lucia; Catassi, Carlo; Fasano, Alessio

doi:10.1016/s1590-8658(06)80197-0

Digestive and Liver Disease

2006

DOI: 10.1016/s1590-8658(06)80197-0

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Serum zonulin and intestinal permeability before and after a gluten-containing meal in both type 1 diabetes and their relatives

Anna Sapone¹,

Laura de Magistris²,

G. Caravelli³

et al.

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Fluctuation of zonulin levels in bloodvsstability of antibodies

Vojdani¹,

Vojdani²,

Kharrazian³

2017

WJG

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AIMTo evaluate the measurement of zonulin level and antibodies of zonulin and other tight junction proteins in the blood of controls and celiac disease patients.METHODSThis study was conducted to assess the variability or stability of zonulin levels vs IgA and IgG antibodies against zonulin in blood samples from 18 controls at 0, 6, 24 and 30 h after blood draw. We also measured zonulin level as well as zonulin, occludin, vinculin, aquaporin 4 and glial fibrillary acidic protein antibodies in the sera of 30 patients with celiac disease and 30 controls using enzyme-linked immunosorbent assay methodology.RESULTSThe serum zonulin level in 6 out of 18 subjects was low or < 2.8 ng/mL and was very close to the detection limit of the assay. The other 12 subjects had zonulin levels of > 2.8 ng/mL and showed significant fluctuation from sample to sample. Comparatively, zonulin antibody measured in all samples was highly stable and reproducible from sample to sample. Celiac disease patients showed zonulin levels with a mean of 8.5 ng/mL compared to 3.7 ng/mL in controls (P < 0.0001). Elevation of zonulin level at 2SD above the mean was demonstrated in 37% of celiac disease patients, while antibodies against zonulin, occludin and other tight junction proteins was detected in up to 86% of patients with celiac disease.CONCLUSIONDue to its fluctuation, a single measurement of zonulin level is not recommended for assessment of intestinal barrier integrity. Measurement of IgG and IgA antibodies against zonulin, occludin, and other tight junction proteins is proposed for the evaluation of the loss of intestinal barrier integrity.

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Fluctuation of zonulin levels in bloodvsstability of antibodies

Vojdani¹,

Vojdani²,

Kharrazian³

2017

WJG

View full text Add to dashboard Cite

show abstract

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Serum zonulin and intestinal permeability before and after a gluten-containing meal in both type 1 diabetes and their relatives

Cited by 1 publication

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Fluctuation of zonulin levels in bloodvsstability of antibodies

Fluctuation of zonulin levels in bloodvsstability of antibodies

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