Serum α-Fetoprotein in the Early Stage of Human Hepatocellular Carcinoma

Chen, Ding‐Shinn; Sung, Juei‐Low; Shed, Jin-Chuan; Lai, Ming-Yang; How, Shu-Wen; Hsu, Hey-Chi; Lee, Chue-Shue; Wei, Tzu-Tang

doi:10.1016/s0016-5085(84)80151-1

Cited by 175 publications

(72 citation statements)

References 18 publications

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“…The specificity and predictive positive value of AFP at a given level are significantly lower in patients with HBsAg, especially when AFP is between 25 and 200 ng/mI. However, Chen et al (28) and Silver et al (29) reported no relationship exists between HBsAg and the specificity of AFP in the hagnosis of HCC. In our study, although the number of the patients with HBsAg was too small to be analyzed, we did not find that regular assays of AFP were more useful in patients without HBsAg.…”

Section: Discussionmentioning

confidence: 97%

Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma

1994

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The usefulness of measurements of serum alpha-fetoprotein elevation for diagnosis of the development of hepatocellular carcinoma was evaluated by a prospective study of 260 patients with cirrhosis. Hepatocellular carcinoma was found in 55 patients during the 5-yr follow-up, excluding 7 found to have hepatocellular carcinoma in the first 6 mo. The cumulative incidence of hepatocellular carcinoma was 26% in the 185 patients who had alpha-fetoprotein levels below 20 ng/ml at the time of entry and 46% in the 68 patients who had alpha-fetoprotein levels of 20 ng/ml or more but below 200 ng/ml. In 169 of the patients, serum levels of alpha-fetoprotein were assayed regularly for at least 2 yr. The incidence of hepatocellular carcinoma development in the 36 patients who had repeated transient increases in alpha-fetoprotein to above 100 ng/ml was 36%. This was significantly higher than the incidence in the 99 patients who had alpha-fetoprotein levels consistently below 20 ng/ml. Thus patients who had alpha-fetoprotein levels of 20 ng/ml or more, who had transient increases in alpha-fetoprotein or who had both should be treated as being in a super-high-risk group for hepatocellular carcinoma. Frequent and careful examination by ultrasonography of such patients is recommended.

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Section: Discussionmentioning

confidence: 97%

Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma

1994

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“…Eighteen patients had elevated AFP levels that coincided with exacerbations in liver disease or replication of hepatitis B virus, and 20 patients had elevations in AFP level for no apparent reason. In retrospectively reviewing AFP values in 17 patients with HCC less than 3 cm, Chen et al 14 reported AFP levels were normal in 35%, and the levels did not correlate with the size of tumor. AFP level was not believed to be a reliable indicator in the early detection of HCC.…”

Section: Discussionmentioning

confidence: 99%

Improved survival with screening for hepatocellular carcinoma

et al. 2000

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“…It has been shown that the serum AFP level may predict the prognosis of patients with HCC [2,3]. At present, the serum AFP concentration is shown to be useful not only in diagnosing HCC, but also as a prognostic indicator [4,51. The serum AFP is occasionally negative in patients with HCC [6] and can also be detected in non-malignant disease [7]. Recently, the immunoperoxidase method of detecting tumor-associated antigens in formalin-fixed, paraffin-embedded tissues has been used widely.…”

Section: Introductionmentioning

confidence: 99%

Alpha‐fetoprotein production by hepatocellular carcinoma is prognostic of poor patients survival

Izumi

Shimizu

Kiriyama

et al. 1992

Journal of Surgical Oncology

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Immunohistochemistry using the avidin-biotin-peroxidase complex method was performed to study the production of alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC) tissue specimens which were obtained surgically. The relationship between staining for AFP and serum AFP levels or pathological findings was examined. The prognosis of the patients with HCC who underwent curative hepatic resections was studied with respect to the staining for AFP in their tumors. The mean serum AFP level in patients with positive AFP staining was significantly higher than in those with negative AFP staining. No significant relationship was found between AFP positivity and tumor size, tumor encapsulation, degree of vascular invasion, or the histological differentiation grade of the tumor. The patients with AFP-positive carcinomas had a poorer prognosis than did those with AFP-negative carcinomas (5-year survival rate of AFP-positive and negative groups were 26.7% and 56.5%, respectively.

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Serum α-Fetoprotein in the Early Stage of Human Hepatocellular Carcinoma

Cited by 175 publications

References 18 publications

Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma

Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma

Improved survival with screening for hepatocellular carcinoma

Alpha‐fetoprotein production by hepatocellular carcinoma is prognostic of poor patients survival

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