Serum α-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment

Dunn, Julie E.; Weıntraub, Sandra; Stoddard, Anne M.; Banks, Sarah J.

doi:10.1212/01.wnl.0000255940.13116.86

Cited by 25 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, an inverse association between plasma vitamin E among others and poor cognitive outcomes was found in at least two cross-sectional studies [179,190] and two cohort studies [196,200]. Another cross-sectional study, however, did not find evidence of an association between plasma antioxidants, including vitamin E and prevalent AD [191].…”

Section: Resultsmentioning

confidence: 99%

“…In sum, of the 21 selected cohort studies linking antioxidants, with focus on vitamin E, to the various cognitive outcomes, 9 (42.9%) found the relationship to be in the hypothesized direction in the entire population that was studied and for most outcomes of interest [176,178,182,184,189,193,194,197,198], while 5 found this relationship for specific antioxidants or some outcomes but not others [180,183,186,196,200,201] and 1 detected it for a sub-group of the total population [183]. The remaining selected cohort studies (n = 6) did not find a significant association [177,185,187,188,192,199].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

et al. 2014

View full text Add to dashboard Cite

BackgroundCognitive impairment, including dementia, is a major health concern with the increasing aging population. Preventive measures to delay cognitive decline are of utmost importance. Alzheimer’s disease (AD) is the most frequent cause of dementia, increasing in prevalence from <1% below the age of 60 years to >40% above 85 years of age.MethodsWe systematically reviewed selected modifiable factors such as education, smoking, alcohol, physical activity, caffeine, antioxidants, homocysteine (Hcy), n-3 fatty acids that were studied in relation to various cognitive health outcomes, including incident AD. We searched MEDLINE for published literature (January 1990 through October 2012), including cross-sectional and cohort studies (sample sizes > 300). Analyses compared study finding consistency across factors, study designs and study-level characteristics. Selecting studies of incident AD, our meta-analysis estimated pooled risk ratios (RR), population attributable risk percent (PAR%) and assessed publication bias.ResultsIn total, 247 studies were retrieved for systematic review. Consistency analysis for each risk factor suggested positive findings ranging from ~38.9% for caffeine to ~89% for physical activity. Education also had a significantly higher propensity for “a positive finding” compared to caffeine, smoking and antioxidant-related studies. Meta-analysis of 31 studies with incident AD yielded pooled RR for low education (RR = 1.99; 95% CI: 1.30-3.04), high Hcy (RR = 1.93; 95% CI: 1.50-2.49), and current/ever smoking status (RR = 1.37; 95% CI: 1.23-1.52) while indicating protective effects of higher physical activity and n-3 fatty acids. Estimated PAR% were particularly high for physical activity (PAR% = 31.9; 95% CI: 22.7-41.2) and smoking (PAR%=31.09%; 95% CI: 17.9-44.3). Overall, no significant publication bias was found.ConclusionsHigher Hcy levels, lower educational attainment, and decreased physical activity were particularly strong predictors of incident AD. Further studies are needed to support other potential modifiable protective factors, such as caffeine.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…However, in this study Vitamin E supplementation appeared to lower the latency of the P3 amplitude but increase its amplitude indicating that antioxidant therapy by decreasing the oxidative stress may lead to improvement in cognitive pool of generator neurons of P3. However, in several human studies vitamin E has not been found to provide cognitive benefits (Kang et al 2006;Dunn et al 2007). …”

Section: Structural Changes In Synapses and Neurotransmitter Sensitivmentioning

confidence: 99%

A metabolic and functional overview of brain aging linked to neurological disorders

et al. 2009

View full text Add to dashboard Cite

Close correlations have recently been shown among the late onset complications encountered in diabetes and aging linked to neurobiological disorders. Aging in females and males is considered as the end of natural protection against age related diseases like osteoporosis, coronary heart disease, diabetes, Alzheimer's disease and Parkinson's disease, dementia, cognitive dysfunction and hypernatremia. Beside the sex hormones other hormonal changes are also known to occur during aging and many common problems encountered in the aging process can be related to neuroendocrine phenomena. Diabetes mellitus is associated with moderate cognitive deficits and neurophysiologic and structural changes in the brain, a condition that may be referred to as diabetes encephalopathy; diabetes increases the risk of dementia especially in the elderly. The current view is that the diabetic brain features many symptoms that are best described as accelerated brain aging. This review presents and compares biochemical, physiological, electrophysiological, molecular, and pathological data from neuronal tissue of aging and hormone treated control and diabetic animals to arrive at the similarities among the two naturally occuring physiological conditions. Animal models can make a substantial contribution to understanding of the pathogenesis, which share many features with mechanism underlying brain aging. By studying the pathogenesis, targets for pharmacology can be identified, finally leading to delay or prevention of these complications. Antiaging strategies using hormone therapy, chemical and herbal compounds were carried out for reversal of aging effects. Neuronal markers have been presented in this review and similarities in changes were seen among the aging, diabetes and hormone treated (estrogen, DHEA and insulin) brains from these animals. A close correlation was observed in parameters like oxidative stress, enzyme changes, and pathological changes like lipofuscin accumulation in aging and diabetic brain.

show abstract

“…dementia, cognitive decline and depression) to variations in serum nutritional biomarkers, including carotenoids, retinol (or retinyl esters), folate, vitamin B-12, total homocysteine (tHcy), vitamin C, D and E (e.g. [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14]). Despite this trend, and the known association between sleep and cognitive as well as affective disorders [15], [16], [17], limited epidemiological research has explored how sleep quantity and quality may be related to serum nutritional biomarkers [18], [19], [20], [21], [22], [23], [24], [25], [26].…”

Section: Introductionmentioning

confidence: 99%

Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

et al. 2014

View full text Add to dashboard Cite

BackgroundThe associations between nutritional biomarkers and measures of sleep quantity and quality remain unclear.MethodsCross-sectional data from the National Health and Nutrition Examination Surveys (NHANES) 2005–2006 were used. We selected 2,459 adults aged 20–85, with complete data on key variables. Five sleep measures were constructed as primary outcomes: (A) Sleep duration; (B) Sleep disorder; (C) Three factors obtained from factor analysis of 15 items and labeled as “Poor sleep-related daytime dysfunction” (Factor 1), “Sleepiness” (Factor 2) and “Sleep disturbance” (Factor 3). Main exposures were serum concentrations of key nutrients, namely retinol, retinyl esters, carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lutein+zeaxanthin, lycopene), folate, vitamin B-12, total homocysteine (tHcy), vitamin C, 25-hydroxyvitamin D (25(OH)D) and vitamin E. Main analyses consisted of multiple linear, logistic and multinomial logit models.ResultsAmong key findings, independent inverse associations were found between serum vitamin B-12 and sleep duration, 25(OH)D and sleepiness (as well as insomnia), and between folate and sleep disturbance. Serum total carotenoids concentration was linked to higher odds of short sleep duration (i.e. 5–6 h per night) compared to normal sleep duration (7–8 h per night).ConclusionsA few of the selected serum nutritional biomarkers were associated with sleep quantity and quality. Longitudinal studies are needed to ascertain temporality and assess putative causal relationships.

show abstract

Serum α-tocopherol, concurrent and past vitamin E intake, and mild cognitive impairment

Abstract: There was weak or no evidence of a protective effect of previous vitamin E intake on cognitive function. However, the association of low concurrent serum alpha-tocopherol with memory and mixed impairment merits further exploration.

Cited by 25 publications

References 41 publications

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

Epidemiologic studies of modifiable factors associated with cognition and dementia: systematic review and meta-analysis

A metabolic and functional overview of brain aging linked to neurological disorders

Serum Nutritional Biomarkers and Their Associations with Sleep among US Adults in Recent National Surveys

Contact Info

Product

Resources

About