Serum γ-glutamyltransferase: Statistical distribution in a middle-aged male population and evaluation of alcohol habits in individuals with elevated levels

Kristenson, Hans; Trell, Erik; Fex, Göran; Hood, B.

doi:10.1016/0091-7435(80)90062-6

Cited by 92 publications

(26 citation statements)

References 16 publications

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“…The number of false-positive values (64%) was S c a d J Prim Health Care IW: 5 too high for serum GT to be useable in this form of screening. Moreover, screening should be aimed at a previously unknown disease condition.…”

Section: Discussionmentioning

confidence: 99%

“…In the largest of these studies, a clear connection has been demonstrated between serum GT and alcohol (4,5,(7)(8)(9)(10)(11). Among men in the general population with serum GT increase, alcohol is the cause in about 6 7 0 % (5, 9,11).…”

mentioning

confidence: 98%

“…It is well known that a number of diseases, overconsumption of alcohohol and certain drugs can affect the serum-GT value (3). In addition, the question has been discussed as to whether overweight, age and sex (4), dietary factors (5) and natural medicines (6) can increase the serum GT level.…”

mentioning

confidence: 99%

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Causes of Elevated Serum Gamma-glutamyl Transferase in Patients Attending Outpatient Somatic Clinics and District Health Centres

Persson

Magnusson

1987

Scandinavian Journal of Primary Health Care

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Section: Discussionmentioning

confidence: 99%

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confidence: 98%

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Causes of Elevated Serum Gamma-glutamyl Transferase in Patients Attending Outpatient Somatic Clinics and District Health Centres

Persson

Magnusson

1987

Scandinavian Journal of Primary Health Care

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“…22 The evaluation of alcohol consumption and smoking has usually been accomplished by questionnaires, which could underestimate the true role of alcohol i6.2o. 2i gy u s i n g ac tual values of GGT and COHb%, which seem to have a relatively good correlation to the long-term effects of alcohol consumption 13 ' l8 " 20 and the amount of tobacco smoke inhaled and absorbed by the body during the preceding 24 hours, 23 it may be possible to better understand the complex interrelationships between these factors and their contribution to recorded BP levels as well as their reproducibility and clinical interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…All these individuals were investigated according to the previously described screening routines. 20 ' 22 All were asked not to smoke in the morning prior to the investigation and during the study.…”

mentioning

confidence: 99%

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Henningsen¹,

Janzon²,

Trell³

1983

Hypertension

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SUMMARY Carboxyhemoglobin (COHb%) and gamma-glutamyl-transferase (GGT) are indicators of tobacco and alcohol consumption; similarly, body weight broadly reflects dietary habits. Relationships between COHb%, GGT, relative body weight, heart rate and blood pressure were studied in 242 48-year-old men attending a general health screening program in Malmo, Sweden. All were without treatment for high blood pressure. Positive correlations were found between blood pressure and body weight, GGT, and pulse, and a reciprocal correlation between blood pressure and COHb%. Use of objective markers for known or suspected risk factors, such as alcohol consumption, smoking, or overweight, were studied to elucidate their usefulness for further prospective studies. (Hypertension 5: 560-563, 1983) KEY WORDS • hypertension • multi-variate analysis • risk factors A RTERIAL hypertension constitutes one of the most important risk factors for cardiovascular morbidity and mortality.1 -2 One of the major aims in several population screening trials has therefore been measurement of blood pressure (BP), with subsequent treatment of individuals with consistently elevated levels. 34 Several factors have been shown to covary with BP, namely, heredity, 5 body weight, 6 -7 salt intake, 8 age, 5 -8 and alcohol consumption.79 " 13 However, smoking and potassium intake seem to be inversely related to BP.914 -' 5 Thus, many exogenous factors may be of pathogenetic and pathophysiologic, as well as methodological, importance to the BP levels recorded, reproducibility, predictive value, clinical interpretation, and resulting treatment.Although body weight at least partly reflects dietary habits in the population, it is usually more difficult to get a reliable history of alcohol consumption, at least in individuals with high consumption levels.' 6 Recent studies tend to indicate a linear relationship between BP and alcohol consumption 7 9~13 and BP and gammaglutamyl-transferase (GGT), 18 " 21 although a flattened relationship has been suggested" after a consumption level of 180 g/week.In a recent statistical evaluation of the relationship between alcohol intake and BP, 12 it was suggested that the individual's "immediate" (24-hour) intake was better correlated to the BP. However, others have found good correlation between BP level and amount of alcohol consumed over several weeks and up to 3 months."-' 3 In our ongoing preventive study 22 of men with persistent hypertension, we found that the higher the GGT level the higher the incidence of moderate-tosevere hypertension; this could also indicate a longer acting effect of high alcohol consumption. Carboxyhemoglobin (CoHB%) is today frequently used for the short-term and objective assessment of tobacco consumption. 23The aim of the present study was to evaluate univariate and multivariate correlations between BP, COHB%, relative bodyweight, GGT, and heart rate in a random subsample of untreated healthy middle-aged (48-year-old) men, and to assess how much of the variability in the blood pressure meas...

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Risk Factors for Impaired Outcome After Spontaneous Intracerebral Hemorrhage

Juvela¹

1995

Archives of Neurology

202

125

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Serum γ-glutamyltransferase: Statistical distribution in a middle-aged male population and evaluation of alcohol habits in individuals with elevated levels

Cited by 92 publications

References 16 publications

Causes of Elevated Serum Gamma-glutamyl Transferase in Patients Attending Outpatient Somatic Clinics and District Health Centres

Causes of Elevated Serum Gamma-glutamyl Transferase in Patients Attending Outpatient Somatic Clinics and District Health Centres

Influence of carboxyhemoglobin, gamma-glutamyl-transferase, body weight, and heart rate on blood pressure in middle-aged men.

Risk Factors for Impaired Outcome After Spontaneous Intracerebral Hemorrhage

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