Serumdigoxinspiegel und Nierenfunktion<sup>*</sup>

Große-Brockhoff, F.; Kj, Hengels; Wp, Fritsch; Grabensee, B; Tu, Hausamen

doi:10.1055/s-0028-1107078

Cited by 24 publications

(2 citation statements)

References 1 publication

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“…Results in subjects with comparable creatinine clearances (table I, II, VII) support this conclu sion, as do results from reports illustrated in figure 3 and from other studies [19,37]. This dose of 0.5 mg is in contrast to the comparable dose of about 0.27 mg predicted by the nomogram of J elliffe and Brooker [32] for a total body digoxin concentration of 10 ¡xg/kg.…”

Section: Renal Function and Digoxin Maintenance Dosecontrasting

confidence: 50%

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Gault¹,

Jeffrey²,

Chirito³

et al. 1976

Nephron

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Section: Renal Function and Digoxin Maintenance Dosecontrasting

confidence: 50%

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Gault¹,

Jeffrey²,

Chirito³

et al. 1976

Nephron

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“…We suggest the use of the presented equation as a guidance to adjust digoxin dosage in VLBW infants with decreased renal function by determination of the creatinine serum concentration. For adults with impaired renal function similar schedules have been established during the recent years (37)(38)(39). For VLBW infants with age-dependent normal renal function proved dose recommendations given in the past should be used (8,9).…”

Section: Discussionmentioning

confidence: 99%

Estimation of Digoxin Dosage in VLBW Infants Using Serum Creatinine Concentrations

Gortner

Hellenbrecht

1986

Acta Paediatrica

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Digoxin steady state plasma concentrations (Css) and the corresponding serum creatinine concentrations were studied in 17 VLBW infants. Birth weight was in the range of 760-1 500 g (mean 1 068 g), gestational age ranged from 26 to 32 weeks (mean 28.7 weeks). Digoxin steady state plasma concentrations were found in the range of 0.5-6.5 ng/ml (mean 1.88 ng/ml) during maintenance therapy with 1.6-8.4 micrograms/kg BW/24 h (mean 4.4 micrograms/kg BW/24 h) given in two divided doses intravenously. No digoxin-like immunoreactive substance could be detected in the plasma of 18 infants (10 patients with a birth weight less than or equal to 1 500 g, 8 patients with a birth weight of 2 100-4 730 g) that were not treated with digoxin. The calculated digoxin clearance ranged from 0.38-4.03 ml/min/kg BW. Serum creatinine concentrations were found in the range of 35-274 mumol/l (0.4-3.1 mg/100 ml). A hyperbolic correlation may be derived from the digoxin clearance and the corresponding serum creatinine concentration. A linear relationship was observed between the dose normalized digoxin concentrations (y = Css/dose in 24 h) and the respective creatinine concentrations x (y = 0.52x-0.05; n = 17; s = 0.24; r = 0.86; p less than 0.01). According to this equation we suggest a dosing schedule for digoxin in VLBW infants with impaired renal function. Digoxin maintenance dose is derived from the digoxin target and the creatinine serum concentration. This dose recommendation proved reliable on four VLBW infants (birth weight 770-1 260 g) with decreased renal function.

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Glykosidtherapie bei Niereninsuffizienz

Rupp¹,

Glöckler²,

Brass³

1982

Digitalistherapie Bei Nieren- Und Leberinsuffizienz

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Serumdigoxinspiegel und Nierenfunktion^*

Cited by 24 publications

References 1 publication

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Estimation of Digoxin Dosage in VLBW Infants Using Serum Creatinine Concentrations

Glykosidtherapie bei Niereninsuffizienz

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Serumdigoxinspiegel und Nierenfunktion*

Cited by 24 publications

References 1 publication

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Studies of Digoxin Dosage, Kinetics and Serum Concentrations in Renal Failure and Review of the Literature

Estimation of Digoxin Dosage in VLBW Infants Using Serum Creatinine Concentrations

Glykosidtherapie bei Niereninsuffizienz

Contact Info

Product

Resources

About

Serumdigoxinspiegel und Nierenfunktion^*