The growing demand for reliability has led to an increased interest in developing effective disconnection systems for enhancing the safety of and preventing failure escalation in engineering systems. Considering this prospect, the design optimization of two disconnection actuators composed of a coaxial magnetic coupling linked to an electromagnetic device is presented and discussed. The disconnection actuator delivers a contactless torque transmission through the coaxial magnetic coupling, whereas the torque transfer is interrupted by the electromagnetic device in case a failure is detected via a dedicated algorithm. The performed design procedure relies on 2D finite element analysis, and trade-off studies are carried out to achieve an optimized geometry of an electromagnetic device. Finally, two disconnection actuators, for high-speed and high-torque applications, are prototyped and tested, with the aim of evaluating their disconnection capability. For both disconnection actuators, the developed force and voltage–current characteristics are measured along with the disconnection time.