As an important device to control the drilling direction in the drilling process, centralizer plays an important role in slowing the deviation and improving the casing centering degree. This paper makes a detailed analysis on the fracture failure of centralizer after multiple repair welding. First, the macroscopic appearance of the port is observed by macroscopic inspection. Secondly, the physical and chemical performance analysis shows that all indicators meet the requirements of the indicators. Finally, through the microscopic morphology, energy dispersive spectrometer (EDS) and other means to analyze the port crack source, combined with a variety of tests to find the true cause of fracture failure centralizer. After inspection, it was found that the centralizer was fatigue fracture, and showed multi-source cracking characteristics. Therefore, strict control of centralizer especially after repair welding quality, strengthen the quality inspection of centralizer, to carry out the relevant thermal processing technology research, and further effectively prevent the occurrence of fracture failure.