“…The more severe the condition, the more pronounced are the cardiovascular alterations, with consistent differences in case of cholestatic, tumoral or cirrhotic etiology of the ESLD [2][3][4]. As experienced by every anesthesiologist involved in a LT program, during surgery the patient may have to tolerate periods (minutes to hours) of tachycardia, severe hypotension, acute blood loss, extreme anemia, markedly reduced venous return, prolonged and resistant vasoplegia after reperfusion of the graft, or, on the contrary, massive transfusion and acute right or left ventricular overload in the various phases of the LT [2][3][4]. To survive such a stressful scenario unscathed, an appropriate (or optimized) cardiovascular performance status is mandatory for the candidate [1][2][3][4], as mandatory is the thorough, extensive, tailored preoperative cardiovascular assessment [2][3][4][5][6].…”