Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial

Farajbakhsh, Ali; Mazloomi, Seyed Mohammad; Mazidi, Mohsen; Rezaie, Peyman; Akbarzadeh, Marzieh; Ahmad, Saeedeh Poor; Ferns, Gordon A.; Ofori‐Asenso, Richard; Babajafari, Siavash

doi:10.1038/s41430-019-0438-5

Cited by 30 publications

(48 citation statements)

References 50 publications

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“…The effectiveness of VE, a powerful antioxidant, has been demonstrated extensively in the treatment of NAFLD; it can improve hepatic steatosis and inflammation in patients with NASH (28). Also, VE improved FBG, HOMA-IR, and insulin in another RCT (29). We expect that the combination of VD and VE supplements can lead to a better effect in the treatment of NAFLD.…”

Section: Discussionmentioning

confidence: 88%

Effects of Vitamin D Supplementation in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Wei

Wang

Yue

et al. 2020

Int J Endocrinol Metab

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Context: Vitamin D (VD) has been found to play a key role in nonalcoholic fatty liver disease (NAFLD). This meta-analysis explored the effects of VD supplementation in patients with NAFLD. Methods: The PubMed, EMBASE, and the Cochrane Library databases were searched to find randomized control trials (RCTs) that measured the changes between the VD supplement group and the control group until May 2019. Standard mean difference (SMD) with 95% confidence intervals (CI) was calculated when data units were different, otherwise weighted mean difference (WMD) and 95% CI was calculated. Heterogeneity was assessed using the I2 statistic. Results: Eight RCTs with 624 individuals were extracted. The main indicators, including serum alanine aminotransferase (WMD = -0.052; 95% CI: -3.740, 3.636; P = 0.978) and aspartate aminotransferase concentrations (WMD = -0.479; 95% CI: -2.791, 1.833; P = 0.685) were not significantly different between the intervention and placebo groups. In addition, no significant intergroup difference was observed in the following secondary indicators: fasting blood glucose (WMD = 0.466; 95% CI: -5.313, -10.879; P = 0.061), homeostasis model assessment (WMD = 0.380, 95% CI: -0.162, 0.923; P = 0.169), serum insulin concentration (WMD = 0.760; 95% CI: -0.532, 2.052; P = 0.249), high-density lipoprotein (WMD = -0.012; 95% CI: -0.188, 0.164; P = 0.891), and low-density lipoprotein (WMD = -0.115; 95% CI: -3.849, -3.620; P = 0.952). Conclusions: The results indicate that VD supplementation does not improve hepatic steatosis, liver enzymes, insulin resistance, glucose metabolism parameters, and lipid levels in patients with NAFLD.

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Section: Discussionmentioning

confidence: 88%

Effects of Vitamin D Supplementation in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Wei

Wang

Yue

et al. 2020

Int J Endocrinol Metab

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“…A total of 605 articles were entered into Endnote for screening, as shown in Figure 1 . After reviewing the titles, abstracts, and subsequently full-texts of remained articles and removing duplicates, eight RCTs [ 14 – 16 , 24 – 28 ] were included in this systematic review.…”

Section: Resultsmentioning

confidence: 99%

“…General characteristics of the included studies are reported in Table 1 . These studies were published between 2006 and 2020 and were conducted in Iran [ 14 , 25 , 26 , 28 ], India [ 16 , 27 ], Brazil [ 24 ], and Pakistan [ 15 ]. The age of the participants and the duration of intervention were 18–70 years and 6–12 weeks, respectively.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial

Yargholi

Najafi

Zareian

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objectives. In recent years, diabetes has become a global health problem that creates a tremendous economic burden for many countries. Clinical trials evaluating the hypoglycemic effects of sesame consumption have produced conflicting results. This systematic review and meta-analysis was conducted to evaluate the effectiveness of sesame as a popular natural herb on glycemic indices in adults. Methods. The search for related articles in PubMed, Scopus, Google Scholar, and Cochrane library was conducted through May 2021. Results were reported as weighted mean differences (WMD) with 95% confidence intervals (CI) using a random-effects model. Results. A total of 605 studies were identified through online searching, and a total of eight RCTs representing 382 participants were included in this study. The meta-analyses revealed that sesame consumption significantly decreases serum fasting blood sugar (FBS): (WMD: −28.23 mg/dl; 95% CI (−39.16, −17.13), I2 = 97.6%; 95% CI (96, 98)), and hemoglobin A1c (HbA1c): (WMD: −1.00%; 95% CI (−1.11, −0.88), I2 = 0%; 95% CI (0, 79)) as compared to the control group. Conclusion. This study provides evidence of the hypoglycemic effects of sesame consumption, particularly in diabetic patients. Additional RCTs on sesame and its preparations should be conducted in different populations to increase generalizability.

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“…Out of 15 polyherbal combinations that were reviewed three formulations were able to modify 4 MetS parameters clinically. They include Yiqi Huazhuo Gushen herbal formula (Tian-zhan et al, 2019), Yiqi Huaju Qingli Formula (Wang et al, 2013), Sesame oil and vitamin E (Farajbakhsh et al, 2019). Six polyherbal combinations were able to reduce three out of 5 standard MetS parameters.…”

Section: Resultsmentioning

confidence: 99%

“…Amongst the combinations reviewed the most effective considered were the ones which met maximum MetS parameters. The maximum parameters modified were 4 out of 5 by 3 combinations including Yiqi Huazhuo Gushen herbal formula (Tian-zhan et al, 2019), Yiqi Huaju Qingli Formula (Wang et al, 2013), and Sesame oil and vitamin E combination (Farajbakhsh et al, 2019). However, these studies were assessed for short period of time ranging from 8 to 12 weeks, which may be helpful in determining the acute effect but not long-term effect and side-effects.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

et al. 2021

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Background: Metabolic syndrome (MetS) is a multifactorial disease, whose main stay of prevention and management is life-style modification which is difficult to attain. Combination of herbs have proven more efficacious in multi-targeted diseases, as compared to individual herbs owing to the “effect enhancing and side-effect neutralizing” properties of herbs, which forms the basis of polyherbal therapies This led us to review literature on the efficacy of herbal combinations in MetS.Methods: Electronic search of literature was conducted by using Cinnahl, Pubmed central, Cochrane and Web of Science, whereas, Google scholar was used as secondary search tool. The key words used were “metabolic syndrome, herbal/poly herbal,” metabolic syndrome, clinical trial” and the timings were limited between 2005–2020.Results: After filtering and removing duplications by using PRISMA guidelines, search results were limited to 41 studies, out of which 24 studies were evaluated for combinations used in animal models and 15 in clinical trials related to metabolic syndrome. SPICE and SPIDER models were used to assess the clinical trials, whereas, a checklist and a qualitative and a semi-quantitative questionnaire was formulated to report the findings for animal based studies. Taxonomic classification of Poly herbal combinations used in animal and clinical studies was designed.Conclusion: With this study we have identified the potential polyherbal combinations along with a proposed method to validate animal studies through systematic qualitative and quantitative review. This will help researchers to study various herbal combinations in MetS, in the drug development process and will give a future direction to research on prevention and management of MetS through polyherbal combinations.

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Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial

Cited by 30 publications

References 50 publications

Effects of Vitamin D Supplementation in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Effects of Vitamin D Supplementation in Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

The Effects of Sesame Consumption on Glycemic Control in Adults: A Systematic Review and Meta-Analysis of Randomized Clinical Trial

Systematic Review of Polyherbal Combinations Used in Metabolic Syndrome

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